A5051312195- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Cutaneous lymphoproliferative disorders research
- Click Chemistry and Applications
- Multiple Myeloma Research and Treatments
- Quinazolinone synthesis and applications
- Complement system in diseases
- Fungal Infections and Studies
- Sarcoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Cytomegalovirus and herpesvirus research
- Infections and bacterial resistance
National Cheng Kung University
2010-2025
National Cheng Kung University Hospital
2015-2024
National Institutes of Health
2024
Singapore General Hospital
2019
Temple College
2017
Palmerston North Hospital
2016
Pingtung Christian Hospital
2015
China Medical University
2011
Kaohsiung Medical University Chung-Ho Memorial Hospital
2011
China Medical University Hospital
2011
Background— Growing evidence suggests that intramyocardial biomaterial injection improves cardiac functions after myocardial infarction (MI) in rodents. Cell therapy is another promising approach to treat MI, although poor retention of transplanted cells a major challenge. In this study, we hypothesized self-assembling peptide nanofibers (NFs) thickens the infarcted myocardium and increases autologous bone marrow mononuclear cell (MNC) attenuate remodeling dysfunction pig MI model. Methods...
Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits various ASS-deficient cancers by depleting arginine. The efficacy of pegylated ADI (ADI-PEG20) relapsed/refractory/poor-risk acute myeloid leukemia (AML) was evaluated 43 patients a prospective, phase II trial (NCT01910012 (10/07/2013), https://clinicaltrials.gov/ct2/show/NCT01910012?term = ADI-PEG20&rank 12 ). Despite almost all pre-treatment tumor...
Peripheral T-cell lymphomas (PTCLs) are uncommon and their frequency is regionally heterogeneous. Several studies have been conducted to evaluate the clinical features treatment outcomes of this disease entity, but majority these were in limited areas, making it difficult comprehensively analyze relative features. Furthermore, no consensus for PTCLs has established. Therefore, we an Asia-specific study understand assess treatments Asian patients.We performed a multinational, multicenter,...
To assess the role of leukapheresis and cranial irradiation in reducing incidence intracranial hemorrhage (ICH) early death patients with hyperleukocytic acute myeloid leukemia (AML) impact such treatment on survival. This study retrospectively analyzed records 75 AML who had a white cell count over 100,000/microL. All de novo except for two therapy-related AML. Various factors were assessed their morbidity mortality, particularly pre-induction leukapharesis irradiation. The most significant...
The antihypertensive drug amiloride is being considered as a tactic to improve cancer therapy including that for chronic myelogenous leukemia. In this study, we show modulates the alternative splicing of various genes, Bcl-x, HIPK3, and BCR/ABL, effect not mainly related pH alteration, which known drug. Splice modulation involved factors, with phosphorylation state serine-arginine-rich (SR) proteins also altered during process. Pretreatment okadaic acid inhibit protein phosphatase PP1...
Eight inorganic ions in fine aerosol particles (D p < 1.3 μm) were measured on board the NCAR C130 and NASA P‐3B aircraft during 2001 Aerosol Characterization Experiment (ACE)‐Asia Transport Chemical Evolution over Pacific (TRACE‐P) experiments, respectively. Concentrations of NH 4 + , SO 2− NO 3 − Ca 2+ K Mg Na Cl determined using a particle‐into‐liquid sampler coupled to ion chromatography (PILS‐IC) technique at 4‐min resolution limit detection <0.05 μg m −3 . The maximum total...
Myelofibrosis (MF) is a progressive disease characterized by accumulation of extracellular matrix (ECM) in the bone marrow (BM) which impairs normal hematopoiesis. While Janus kinase (JAK) inhibitors reduce spleen volume and provide symptomatic improvement, they do not resolve BM fibrosis may cause or exacerbate anemia thrombocytopenia. An anti-fibrotic therapy capable normalising microenvironment function remains significant gap current treatment landscape. MF associated with elevated...
Inactivation of glycogen synthase kinase (GSK)-3 has been implicated in cancer progression. Previously, we showed an abundance inactive GSK-3 the human chronic myeloid leukemia (CML) cell line. CML is a hematopoietic malignancy caused by oncogenic Bcr-Abl tyrosine kinase. In signaling, role not well defined. Here, report that enforced expression constitutively active reduced proliferation and increased inhibition-induced apoptosis nearly 1-fold. inhibition activated GSK-3-dependent...
Serous effusions are a common manifestation of diffuse large B-cell lymphoma (DLBCL). However, their prognostic significance is controversial.We searched for consecutive patients who had DLBCL with from 1999 through 2007. Primary effusion was excluded. The presence tumor cells in (malignant effusions) determined by cytology supplemented flow cytometry, cell blocks special studies, polymerase chain reaction clonality, or conventional cytogenetics.Forty-one (18.4%) effusions, 24 (58.5%)...
Abstract Background Glofitamab is a bispecific antibody with promise for treating relapsed/refractory B‐cell lymphoma according to phase 1/2 clinical trial. This study examined its real‐world effectiveness. Methods was an investigator‐initiated, multicenter retrospective including 34 patients who had lymphomas after at least three prior lines of therapy and received glofitamab monotherapy in compassionate use program Taiwan between January 2021 October 2022. Results At median follow‐up 15.9...
Cytomegalovirus (CMV) can cause infection and critical diseases in hematopoietic stem cell transplantation (HSCT) recipients. This study aimed to explore the cumulative incidence risk factors for CMV disease among HSCT recipients Taiwan.
Yeh Y‐M, Chang K‐C, Chen Y‐P, Kao L‐Y, Tsai H‐P, Ho C‐L, Wang J‐R, Jones D & T‐Y (2010) Histopathology 57, 785–795 Large B cell lymphoma presenting initially in bone marrow, liver and spleen: an aggressive entity associated frequently with haemophagocytic syndrome Aims: To describe diffuse large (DLBCL) spleen (BLS‐type) without lymphadenopathy. Methods results: The clinicopathological cytogenetic features of 11 such cases (eight men, three women; mean age: 62.7 years are described)....
Host immunity likely plays a role in preventing progression of diffuse large B-cell lymphoma (DLBCL). Analysis host immune cells may provide useful information for assessing prognosis or possibly clinical management.Peripheral blood samples from 77 patients with DLBCL and 30 healthy volunteers were analyzed using flow cytometry immunophenotyping. CBC counts, T-cell subsets, dendritic (DCs) detected, the results correlated clinicopathologic characteristics.Compared volunteers, had...
A phase II trial was conducted to evaluate the therapeutic efficacy and safety profiles of frontline concurrent chemoradiotherapy (CCRT) plus consolidation chemotherapy for patients with stage I/II nasal natural killer/T-cell lymphoma (NKTCL).Patients newly diagnosed, measurable NKTCL were eligible. The CCRT included two cycles DEP regimen (dexamethasone, etoposide, cisplatin) every 4 wk 5040 cGy radiation in 28 fractions 5 wk. Patients without disease progression after subjected DVIP...
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening complication caused by platelet activation via factor 4 (PF4) antibodies. We report healthy 28-year-old man who developed hemoptysis, bilateral leg pain, and headaches three weeks after his third dose of the COVID-19 vaccine with first BNT162b2 (from Pfizer-BioNTech) injection. He had previously second doses ChAdOx1 nCov-19 without any discomfort. Serial investigations demonstrated pulmonary embolisms, cerebral...
Abstract Most acute myeloid leukemia (AML) cells are argininosuccinate synthetase‐deficient. Pegylated arginine deiminase (ADI‐PEG20) monotherapy depletes circulating arginine, thereby selectively inducing tumor cell death. ADI‐PEG20 was shown to induce complete responses in ~10% of relapsed/refractory or poor‐risk AML patients. We conducted a phase I, dose‐escalation study combining and low‐dose cytarabine (LDC) Patients received 20 mg LDC subcutaneously twice daily for 10 days every 28 at...
Abstract Herpes simplex virus type 1 (HSV‐1) can establish latency in humans and easily relapse immunocompromised patients, with significant mortality. Treatment acyclovir (ACV) result the emergence of HSV resistance. A total 440 frozen HSV‐1 isolates collected from 318 patients January 2014 to July 2019 were obtained National Cheng Kung University Hospital southern Taiwan. These subjected phenotypic studies for ACV‐resistance by initial screening plaque reduction assay (PRA) further...
Quantitation of cytomegalovirus (CMV) viral load in the transplant patients has become a standard practice for monitoring response to antiviral therapy. The cut-off values CMV assays preemptive therapy are different due various assay designs employed. To establish sensitive and reliable diagnostic infection, two commercial automated platforms including m2000sp extraction system integrated Abbott RealTime (m2000rt) Roche COBAS AmpliPrep Taqman (CAP/CTM) were evaluated using WHO international...