A5040621608- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
Sichuan University
2025
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
State Key Laboratory of Oncology in South China
2013-2024
Key Laboratory of Guangdong Province
2024
Karolinska University Hospital
2012-2015
Karolinska Institutet
2012-2015
Abstract Purpose: Relapsed or refractory diffuse large B-cell lymphoma (rrDLBCL) is fatal in 90% of patients, and yet little known about its biology. Experimental Design: Using exome sequencing, we characterized the mutation profiles 38 rrDLBCL biopsies obtained at time progression after immunochemotherapy. To identify genes that may be associated with relapse, compared frequency samples relapse to an unrelated cohort 138 diagnostic DLBCLs separately amplified specific mutations their...
Abstract The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 subtypes, including tumour-infiltrating CD8 + T, regulatory (Treg), and dendritic (DCs), as well malignant different Epstein-Barr virus infection status. Trajectory exhausted...
Triple-negative breast cancer (TNBC) is associated with poor prognosis and high probability of distant metastases. Tumor microenvironments play a pivotal role in tumor metastasis. Tumor-associated macrophages (TAMs) are one the main cell components, they correlated increasing metastatic risk. The aim this study to analyze prognostic significance infiltration TAMs patients TNBC.Immunohistochemical staining for cluster differentiation (CD)68 (a marker macrophages) was performed on tissue...
Among all subtypes of breast cancer, triple-negative cancer has a relatively high relapse rate and poor outcome after standard treatment. Effective strategies to reduce the risk death are needed.To evaluate efficacy adverse effects low-dose capecitabine maintenance adjuvant chemotherapy in early-stage cancer.Randomized clinical trial conducted at 13 academic centers sites China from April 2010 December 2016 final date follow-up was 30, 2020. Patients (n = 443) had completed...
// Tao Qin 1,* , Yin-duo Zeng 1,2,* Ge Fei Xu Jia-bin Lu 1 Wen-feng Fang Cong Xue Jian-hua Zhan Xin-ke Zhang Qiu-fan Zheng Rou-jun Peng Zhong-yu Yuan Li and Shu-sen Wang Sun Yat-sen University Cancer Center, The State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Medicine, Guangzhou, Guangdong, P. R. China 2 Memorial Hospital, * These authors have contributed equally to this work Correspondence to: Wang, email: Zhang, Yuan, Keywords : PD-L1, breast cancer,...
The genetic mechanisms underlying disease progression, relapse and therapy resistance in mantle cell lymphoma (MCL) remain largely unknown. Whole-exome sequencing was performed 27 MCL samples from 13 patients, representing the largest analyzed series of consecutive biopsies obtained at diagnosis and/or for this type lymphoma. Eighteen genes were found to be recurrently mutated these samples, including known (ATM, MEF2B MLL2) novel mutation targets (S1PR1 CARD11). CARD11, a scaffold protein...
Extranodal natural killer T-cell lymphoma (nasal type; NKTCL) is an aggressive malignancy strongly associated with Epstein-Barr virus (EBV) infection. However, the role of EBV in NKTCL development unclear, largely due to lack information about genome and transcriptome NKTCL. Here, using high-throughput sequencing, we obtained whole (n = 27) datasets 18) derived from tumor biopsies. We assembled 27 genomes detected average 1,152 single nucleotide variants 44.8 indels (<50 bp) per sample. also...
The prognostic value of traditional clinical indicators for locally recurrent nasopharyngeal carcinoma is limited because their inability to reflect intratumor heterogeneity. We aimed develop a radiomic signature reveal tumor immune heterogeneity and predict survival in carcinoma.
Epstein-Barr virus (EBV)-encoded molecules have been detected in the tumor tissues of several cancers, including nasopharyngeal carcinoma (NPC), suggesting that EBV plays an important role tumorigenesis. However, nature with respect to genome width vivo and whether undergoes clonal expansion are still poorly understood. In this study, next-generation sequencing (NGS) was used sequence DNA extracted directly from tissue a patient NPC. Apart human sequences, clinically isolated 164.7 kb size...
DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of immunoglobulin genes by V(D)J recombination, hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability malignant transformation in cells. By performing targeted sequencing 73 key 29 lymphoma samples, germline mutations were identified various pathways, mainly diffuse large lymphomas (DLBCLs). Mutations mismatch (EXO1, MSH2, MSH6)...
Rationale: Epstein-Barr virus (EBV) is associated with multiple malignancies expression of viral oncogenic proteins and chronic inflammation as major mechanisms contributing to tumor development.A less well-studied mechanism the integration EBV into human genome possibly at sites which may disrupt gene or stability.Methods: We sequenced DNA profile sequences by hybridization-based enrichment.Bioinformatic analysis was used detect breakpoints integrations in cancer cells.Results: identified...
Breast cancer research and treatment by different subtypes is an inevitable trend. We investigated the clinicopathologic features outcomes of breast in Southern China. A total 5809 patients with invasive ductal carcinomas were identified. Immunohistochemical (IHC) markers for estrogen receptor (ER), progesterone (PR), Her2/neu, Ki-67 proliferation index used to classify cases into five molecular subtypes. Clinicopathologic characteristics survival rates analyzed retrospectively. Of all...
Breast cancer is one of the most common malignancies in women. Approximately 15% patients belong to triple-negative breast (TNBC) group, and have disadvantage not benefiting from currently available receptor-targeted systemic therapies. Some cancers TNBC group harbor defects DNA double-strand break repair by homologous recombination (HR), such as BRCA1 dysfunction, are hypersensitive poly (ADP-ribose) polymerase (PARP) inhibition. However, only a small fraction tumors BRCA-deficient, this...
Cernunnos is involved in the nonhomologous end-joining (NHEJ) process during DNA double-strand break (DSB) repair. Here, we studied immunoglobulin (Ig) class switch recombination (CSR), a physiological which relies on proper repair of DSBs, B cells from Cernunnos-deficient patients. The pattern vivo generated CSR junctions altered these cells, with unusually long microhomologies and lack direct end-joining. patients largely resemble those lacking ligase IV, Artemis, or ATM, suggesting that...