A5014737817- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Impact of Technology on Adolescents
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Child Development and Digital Technology
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Drug Transport and Resistance Mechanisms
- Social Media and Politics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Global Cancer Incidence and Screening
- Viral-associated cancers and disorders
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Digital Mental Health Interventions
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
State Key Laboratory of Oncology in South China
2016-2025
Chongqing Public Health Medical Center
2012-2025
Chongqing Medical University
2014-2025
State Key Laboratory of Pollution Control and Resource Reuse
2022-2025
Nanjing University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Soochow University
2024
Air Force Medical University
2022-2024
Interventional hepatic arterial infusion chemotherapy of infusional fluorouracil, leucovorin, and oxaliplatin (HAIC-FO) displayed an encouraging safety profile antitumor activity in a previous phase II trial propensity-score-matching study involving patients with locally advanced hepatocellular carcinoma (HCC).In this open-label, III trial, HCC, previously untreated systemic therapy, were randomly assigned 1:1 ratio to receive HAIC-FO or sorafenib. The primary end point was overall survival...
The role of locoregional radiotherapy in patients with de novo metastatic nasopharyngeal carcinoma (mNPC) is unclear.To investigate the efficacy and safety mNPC.Patients biopsy-proven mNPC, who demonstrated complete or partial response (RECIST v1.1) following 3 cycles cisplatin fluorouracil chemotherapy, were enrolled. Eligible randomly assigned (1:1) to receive either chemotherapy plus alone. Overall, 126 173 screened eligible study, randomized (n = 63) alone 63). Median (IQR) follow-up...
Among all subtypes of breast cancer, triple-negative cancer has a relatively high relapse rate and poor outcome after standard treatment. Effective strategies to reduce the risk death are needed.To evaluate efficacy adverse effects low-dose capecitabine maintenance adjuvant chemotherapy in early-stage cancer.Randomized clinical trial conducted at 13 academic centers sites China from April 2010 December 2016 final date follow-up was 30, 2020. Patients (n = 443) had completed...
This is a phase Ib/II study of regorafenib plus toripalimab for colorectal cancer. The objective response rate (ORR) 15.2% and the disease control 36.4% in evaluable patients with recommended II dose (80 mg toripalimab). median progression-free survival (PFS) overall are 2.1 months 15.5 months, respectively. Patients liver metastases have lower ORR than those without (8.7% versus 30.0%). All (3/3) lung-only metastasis respond, whereas no (0/4) liver-only respond. 94.9% 38.5% grade 1 3...
To report the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil oxaliplatin (FOLFOX) in hepatocellular carcinoma (HCC) patients microvascular invasion (MVI).In this randomized, open-label, multicenter trial, histologically confirmed HCC MVI were randomly assigned (1:1) to receive FOLFOX-HAIC (treatment group) or routine follow-up (control group). The primary end point was disease-free survival (DFS) by intention-to-treat (ITT)...
Abstract Hepatic arterial infusion chemotherapy (HAIC) using a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown promise for hepatocellular carcinoma (HCC) patients classified under Barcelona Clinic Liver Cancer (BCLC) stage C. In China, the combined therapy camrelizumab apatinib is now an approved first-line approach inoperable HCC. This study (NCT04191889) evaluated benefit combining with HAIC-FOLFOX HCC in BCLC Eligible were given maximum six cycles HAIC-FOLFOX,...
The AJCC/UICC TNM classification describes anatomic extent of tumor progression and guides treatment decisions. Our comprehensive analysis 8,834 newly diagnosed patients with non-metastatic Epstein-Barr virus related nasopharyngeal carcinoma (NPC) from six Chinese centers indicates certain limitations in the current staging system. 8th edition inadequately differentiates patient outcomes, particularly between T2 T3 categories within N classification. We propose reclassifying cases NPC early...
Recurrence risks of cancer patient can change during treatment as a result treatment-related tumor evolution. However, biomarkers that monitor these changes are lacking. Here, we investigated whether tracking circulating DNA (ctDNA) dynamics through liquid biopsy inform real-time recurrence risk. Nasopharyngeal carcinoma (NPC) provides an ideal model where cell-free Epstein-Barr virus (EBV) (cfEBV DNA), ctDNA, be sensitively detected. We conducted the EP-SEASON study (NCT03855020) and...
Abstract Background Nearly 90% locoregionally advanced nasopharyngeal carcinoma (LANPC) responds to induction chemotherapy (IC) with significant tumor volume shrinkage. Radiotherapy always follows IC, and reduced has been proposed. However, the efficacy safety of reduced‐volume radiotherapy is uncertain. Methods In this multi‐center, noninferiority, randomized, controlled trial, patients LANPC who completed IC were randomly assigned (1:1) receive based on post‐IC (Post‐IC group) or...
Background and aims This study to examine the mediating effects of insomnia on associations between problematic Internet use, including addiction (IA) online social networking (OSNA), depression among adolescents. Methods A total 1,015 secondary school students from Guangzhou in China participated a cross-sectional survey. Levels depression, insomnia, IA, OSNA were assessed using Center for Epidemiological Studies-Depression Scale, Pittsburgh Sleep Quality Index, Young’s Diagnostic...
Background and aims The aim of this study is to estimate the longitudinal associations between online social networking addiction (OSNA) depression, whether OSNA predicts development reversely, depression OSNA. Methods A total 5,365 students from nine secondary schools in Guangzhou, Southern China were surveyed at baseline March 2014, followed up 9 months later. Level measured using validated scale CES-D, respectively. Multilevel logistic regression models applied depression. Results...
Background/Aims: Doxorubicin (DOX) is a widely used chemotherapeutic agent for colorectal cancer (CRC). However, the acquirement of DOX resistance limits its clinical application therapy. Mounting evidence has suggested that aberrantly expressed lncRNAs contribute to drug various tumors. Our study aimed explore role and molecular mechanisms lncRNA X-inactive specific transcript (XIST) in chemoresistance CRC DOX. Methods: The expressions XIST, miR-124, serum glucocorticoid-inducible kinase 1...
Cumulative doses of 200 mg/m2 for concurrent cisplatin (DDP) were indicated by retrospective studies as sufficient in conferring survival benefit locoregionally advanced nasopharyngeal carcinoma (LA-NPC). We performed an open-label, phase II, randomized, controlled trial to test the noninferiority a two-cycle 100 DDP regimen over three-cycle patients with low-risk LA-NPC pretreatment Epstein-Barr virus DNA levels < 4,000 copies/mL.Eligible randomly assigned 1:1 receive two cycles or three...
Rationale: Over 40% of lung cancer cases occurred in never-smokers China. However, high-risk were precluded from benefiting screening as most guidelines did not consider them. Objectives: We sought to develop and validate prediction models for 3-year risks never- ever-smokers, named the China National Cancer Center Lung (China NCC-LCm2021 models). Methods: 425,626 128,952 ever-smokers Screening program used training cohort analyzed using multivariable Cox models. Models validated two...