A5062372552- Breast Cancer Treatment Studies
- Sarcoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Bone Tumor Diagnosis and Treatments
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cerebral Palsy and Movement Disorders
- RNA modifications and cancer
- Meningioma and schwannoma management
- Genetic Syndromes and Imprinting
- Metastasis and carcinoma case studies
- Cancer and Skin Lesions
- PARP inhibition in cancer therapy
- Fetal and Pediatric Neurological Disorders
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
University of Alabama at Birmingham
2016-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Tianjin Medical University General Hospital
2025
Quzhou University
2025
Harbin Institute of Technology
2025
Northwest A&F University
2025
Zhejiang University
2025
Guangxi Normal University
2024
Fudan University Shanghai Cancer Center
2024
Tsinghua University
2011-2024
Trastuzumab deruxtecan (T-DXd) has shown efficacy in patients with breast cancer ERBB2 immunohistochemistry (IHC) scores of 1+ or 2+ but not 0 as read central pathology laboratories. The drug is currently being tested large randomized clinical trials registration intent for this patient population. To determine the suitability current standard IHC assays to select low positivity treatment T-DXd. Assessment data from College American Pathologists surveys and assessment analytic a Yale...
Abstract Through unbiased metabolomics, we identified elevations of the metabolite 2-hydroxyglutarate (2HG) in renal cell carcinoma (RCC). 2HG can inhibit 2-oxoglutaratre (2-OG)–dependent dioxygenases that mediate epigenetic events, including DNA and histone demethylation. accumulation, specifically d enantiomer, result from gain-of-function mutations isocitrate dehydrogenase (IDH1, IDH2) found several different tumors. In contrast, kidney tumors demonstrate l enantiomer (l-2HG). High-2HG...
The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance.We explored the relationship between clinicopathologic factors and common sites metastasis in 531 consecutive patients with advanced cancer.Breast subtype as a variable was significantly associated all five relapse by multivariate analysis. luminal tumors were remarkable for their bone-seeking phenotype less frequently observed lung, brain, pleural metastases likely be multiorgan...
<h3>Importance</h3> Pathologic complete response (pCR) is a known prognostic biomarker for long-term outcomes. The I-SPY2 trial evaluated if the strength of this clinical association persists in context phase 2 neoadjuvant platform trial. <h3>Objective</h3> To evaluate pCR with event-free survival (EFS) and distant recurrence–free (DRFS) subpopulations women high-risk operable breast cancer treated standard therapy or one several novel agents. <h3>Design, Setting, Participants</h3>...
Among all subtypes of breast cancer, triple-negative cancer has a relatively high relapse rate and poor outcome after standard treatment. Effective strategies to reduce the risk death are needed.To evaluate efficacy adverse effects low-dose capecitabine maintenance adjuvant chemotherapy in early-stage cancer.Randomized clinical trial conducted at 13 academic centers sites China from April 2010 December 2016 final date follow-up was 30, 2020. Patients (n = 443) had completed...
The fertilized mouse egg actively demethylates the paternal genome within a few hours after fertilization, whereas maternal is only passively demethylated by replication-dependent mechanism two-cell stage. This evolutionarily conserved assymetry in early diploid mammalian embryo may have role methylation reprogramming of two very different sets sperm and chromatin for somatic development formation totipotent cells. Immunofluorescence staining with an antibody against 5-methylcytosine (MeC)...
Tri-methylated lysine 20 on histone H4 (Me(3)K20H4) is a marker of constitutive heterochromatin in murine interphase and metaphase cells. Heterochromatin marked by Me(3)K20H4 replicates late during S phase the cell cycle. Serum starvation increases number cells that exhibit high levels at heterochromatin. also present centromeric most meiotic chromosomes spermatogenesis pseudoautosomal region, as well some telomeres. It not XY-body. During embryogenesis maternal pronucleus contains...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with high mortality. Macrophages neutrophils responsible for inflammatory responses in ALI ARDS, which characterized by excessive production of proinflammatory mediators bronchoalveolar lavage fluid (BALF) plasma. Aberrant activation the JAK/STAT pathway is critical persistent inflammation many conditions such as infection autoimmunity. Given importance STAT3 transcription factor activating macrophages...
ABSTRACT The novel low-pathogenic avian influenza A H7N9 viruses (LPAI viruses) have been a threat to public health since their emergence in 2013 because of the high rates mortality and morbidity that they cause. Recently, highly pathogenic variants these (HPAI emerged caused human infections outbreaks among poultry mainland China. However, it is still unclear how HPAI virus was generated evolved spread Here, we show ancestor originated Yangtze River Delta region southward Pearl region,...
Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive.We investigated FOXP3-inducible breast cells, Foxp3 heterozygous Scurfy mutant (Foxp3 sf/+ ) female mice, and patients with for characterization formation regulation miR-200 family cells circulation. Participants (259), including or benign tumors, members families, healthy controls, were assessed circulating levels family.First,...
<h3>Importance</h3> Residual cancer burden (RCB) distributions may improve the interpretation of efficacy in neoadjuvant breast trials. <h3>Objective</h3> To compare RCB between randomized control and investigational treatments within subtypes explore relationship with survival. <h3>Design, Setting, Participants</h3> The I-SPY2 is a multicenter, platform adaptive, clinical trial US that compares, by subtype, agents combination chemotherapy vs alone adult women stage 2/3 at high risk early...
Abstract Chemotherapy elicits tumor immune evasion with poorly characterized mechanisms. Here, we demonstrate that chemotherapy markedly enhances the expression levels of CD47 in osteosarcoma tissues, which are positively associated patient mortality. We reveal macrophages response to secrete interleukin-18, turn upregulates L-amino acid transporter 2 (LAT2) cells for substantially enhanced uptakes leucine and glutamine, two potent stimulators mTORC1. The increased glutaminolysis activate...
Abstract Human tubulin beta class IVa (TUBB4A) is a member of the β-tubulin family. In most normal tissues, expression TUBB4A little to none, but it highly expressed in human prostate cancer. Here we show that high levels are associated with aggressive cancers and poor patient survival, especially for African-American men. Additionally, cancer cells, knockout (KO) reduces cell growth migration induces DNA damage through increased γH2AX 53BP1. Furthermore, during constricted migration,...
Active demethylation of the paternal genome but not maternal occurs in fertilized mouse, rat, pig, and bovine zygotes. To study whether this early wave is important for embryonic development, we have analyzed global methylation patterns both vivo-fertilized cloned rabbit embryos. Anti-5-methylcytosine immunofluorescence embryos revealed that equally high levels genomes are largely maintained from zygote up to 16-cell stage. The lack detectable changes preimplantation suggests genome-wide an...
HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their exact physiological function remains unknown. In a first attempt elucidate the these vivo, we disrupted murine Cbx1 gene, which encodes HP1-β isotype, and show that Cbx1−/−-null mutation leads perinatal lethality. The newborn mice succumbed acute respiratory failure, whose likely cause is defective development neuromuscular junctions within endplate diaphragm. We also observe aberrant cerebral...
Abstract Hypoxia is a crucial factor in tumor aggressiveness and resistance to therapy, especially glioblastoma. Our previous results have shown that melatonin exerts antimigratory anti‐invasive action glioblastoma cells under normoxia. However, the effect of on migration invasion hypoxic condition remains poorly understood. Here, we show strongly reduced hypoxia‐mediated U 251 87 cells. In addition, found significantly blocked HIF ‐1α protein expression suppressed downstream target genes,...