A5009307075- Atmospheric chemistry and aerosols
- Influenza Virus Research Studies
- Air Quality and Health Impacts
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Air Quality Monitoring and Forecasting
- Viral gastroenteritis research and epidemiology
- Physical Activity and Health
- Advanced Chemical Sensor Technologies
- Atmospheric aerosols and clouds
- Atmospheric Ozone and Climate
- interferon and immune responses
- Vehicle emissions and performance
- Obesity, Physical Activity, Diet
- Viral Infections and Vectors
- Balance, Gait, and Falls Prevention
- Stroke Rehabilitation and Recovery
- Urban Transport and Accessibility
- Analytical Chemistry and Chromatography
- Sports Performance and Training
- RNA and protein synthesis mechanisms
- Toxic Organic Pollutants Impact
- Noise Effects and Management
- Chemical Thermodynamics and Molecular Structure
- Forensic Fingerprint Detection Methods
National Institute for Viral Disease Control and Prevention
2016-2025
University of Shanghai for Science and Technology
2023-2025
Shaanxi Normal University
2015-2025
Center for Disease Control
2013-2024
China Pharmaceutical University
2024
Taizhou University
2020-2024
Nanjing University of Chinese Medicine
2024
National Marine Environmental Forecasting Center
2024
State Key Joint Laboratory of Environment Simulation and Pollution Control
2020-2023
Peking University
2020-2023
Infection of poultry with influenza A subtype H7 viruses occurs worldwide, but the introduction this to humans in Asia has not been observed previously. In March 2013, three urban residents Shanghai or Anhui, China, presented rapidly progressing lower respiratory tract infections and were found be infected a novel reassortant avian-origin (H7N9) virus.We obtained analyzed clinical, epidemiologic, virologic data from these patients. Respiratory specimens tested for other by means real-time...
Abstract. Nitro-aromatic compounds (NACs), as important contributors to the light absorption by brown carbon, have been widely observed in various ambient atmospheres; however, their formation urban atmosphere was little studied. In this work, we report an intensive field study of NACs summer 2016 at Beijing site, characterized both high-NOx and anthropogenic VOC dominated conditions. We investigated factors that influence NAC (e.g., NO2, precursors, RH photolysis) through quantification...
Abstract. Nitro-aromatic compounds (NACs) were measured hourly at a rural site in China during wintertime to monitor the changes due local and regional impacts of biomass burning (BB). Concurrent continuous measurements concentrations 16 NACs gas particle phases performed with time-of-flight chemical ionization mass spectrometer (CIMS) equipped Filter Inlet for Gases AEROsols (FIGAERO) unit using iodide as reagent ion. accounted <2 % concentration organic matter (OM) total particulate...
The recent increase in zoonotic avian influenza A(H7N9) disease China is a cause of public health concern. Most the viruses previously reported have been low pathogenicity. We report fatal case patient who was infected with an virus having polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), suggestive high pathogenicity birds. Its neuraminidase also had R292K, change known to be associated inhibitor resistance. Both these molecular features might contributed...
ABSTRACT The novel low-pathogenic avian influenza A H7N9 viruses (LPAI viruses) have been a threat to public health since their emergence in 2013 because of the high rates mortality and morbidity that they cause. Recently, highly pathogenic variants these (HPAI emerged caused human infections outbreaks among poultry mainland China. However, it is still unclear how HPAI virus was generated evolved spread Here, we show ancestor originated Yangtze River Delta region southward Pearl region,...
Purpose Emerging evidence suggests physical activity (PA) is associated with cognitive function. To overcome limitations of self-report PA measures, this study investigated the association accelerometer-measured incident impairment and longitudinal cognition among older adults. Methods Participants were recruited from cohort Reasons for Geographic Racial Differences in Stroke United States. Accelerometers provided including percentage total accelerometer wearing time spent...
Abstract. Organosulfates (OSs) with ambiguous formation mechanisms are a potential source of missing secondary organic aerosol (SOA) in current atmospheric models. In this study, we chemically characterized OSs and nitrooxy-OSs (NOSs) formed under the influence biogenic emissions anthropogenic pollutants (e.g., NOx, SO42−) summer Beijing. An ultrahigh-resolution mass spectrometer equipped an electrospray ionization was applied to examine overall molecular composition S-containing organics....
The COVID-19 epidemic adversely affects the lifestyle of people. This study aimed to examine impacts social isolation on physical activity (PA) levels and mood states children adolescents explore correlation between them during epidemic. A total 9979 (11.63 ± 1.23 years old) from Yan’an, China volunteered participate in this completed online questionnaires. PA were measured by International Physical Activity Questionnaire Short Form (IPAQ-SF) Profile Mood States (POMS), respectively. results...
Abstract. Nocturnal reactive nitrogen compounds play an important role in regional air pollution. Here we present the measurements of dinitrogen pentoxide (N2O5) associated with nitryl chloride (ClNO2) and particulate nitrate (pNO3-) at a suburban site Beijing summer 2016. High levels N2O5 ClNO2 were observed outflow urban masses, 1 min average maxima 937 2900 pptv, respectively. The uptake coefficients, γ, yield, f, experimentally determined from parameters. coefficient ranged 0.012 to...
With no or low virulence in poultry, avian influenza A(H7N9) virus has caused severe infections humans. In the current fifth epidemic wave, a highly pathogenic (HPAI) H7N9 emerged. The insertion of four amino acids (KRTA) at haemagglutinin (HA) cleavage site enabled trypsin-independent infectivity this virus. Although maintaining dual receptor-binding preference, its HA antigenicity was distinct from low-pathogenic A(H7N9). neuraminidase substitution R292K conferred multidrug resistance phenotype.
Abstract. A time-of-flight chemical ionization mass spectrometer (CIMS) utilizing the Filter Inlet for Gas and Aerosol (FIGAERO) was deployed at a regional site 40 km north-west of Beijing successfully identified measured 17 sulfur-containing organics (SCOs are organo/nitrooxy organosulfates sulfonates) with biogenic anthropogenic precursors. The SCOs were quantified using laboratory-synthesized standards lactic acid sulfate nitrophenol organosulfate (NP OS). variation in field observations...
Due to enzootic infections in poultry and persistent human China, influenza A (H7N9) virus has remained a public health threat. The Yangtze River Delta region, which is located eastern well recognized as the original source for H7N9 outbreaks. Based on evolutionary analysis of viruses from all three outbreak waves since 2013, we identified Pearl region an additional source. are repeatedly introduced these two sources other areas, circulation occurs poultry, causing continuous waves. Poultry...
Restricted outdoor activities and online learning during COVID-19 pandemic may pose threats on the physical mental health of Chinese adolescents in middle schools. The study was to explore relationship Physical Activity (PA) Sedentary Time (SED) with mood states among pandemic.A total 4898 (16.3 ± 1.3 years old) from 49 schools 13 urban rural areas Yan'an, China volunteered participate this completed questionnaires. International Questionnaire (IPAQ) were used measure PA SED, Profile Mood...
ABSTRACT Clade 2.3.4.4 highly pathogenic avian influenza viruses (H5Nx) have spread from Asia to other parts of the world. Since 2014, human infections with clade H5N6 been continuously reported in China. To investigate genesis virus, we analyzed 123 H5 or N6 environmental sampled live-poultry markets farms 2012 2015 Mainland Our results indicated that H5N2/N6/N8 shared same hemagglutinin gene as originated early 2009. From 2015, occurred via two independent pathways. Three major reassortant...
Exercise training has been reported to alleviate cardiac fibrosis and ameliorate heart dysfunction after myocardial infarction (MI), but the molecular mechanism is still not fully clarified. Fibroblast growth factor 21 (FGF21) exerts a protective effect on infarcted heart. This study investigates whether exercise could increase FGF21 protein expression regulate transforming factor-β1 (TGF-β1)-Smad2/3-MMP2/9 signaling pathway following MI. Male wild type (WT) C57BL/6J mice Fgf21 knockout...
Cooking has been proven to be a significant source of primary organic aerosol, especially in megacities. However, the formation secondary aerosol (SOA) derived from cooking emissions is still poorly understood. In this work, four prevalent Chinese domestic types involving complicated cuisines and various methods were chosen conduct lab simulation for SOA using Gothenburg potential mass reactor (Go: PAM). After samples had aged under OH exposures 4.3–27.1 × 1010 molecules cm–3 s, was...
Abstract. Organosulfates (OSs) are ubiquitous in the atmosphere and serve as important tracers for secondary organic aerosols (SOAs). Despite intense research over years, abundance, origin, formation mechanisms of OSs ambient aerosols, particularly regions with severe anthropogenic pollution, still not well understood. In this study, we collected filter samples fine particulate matter (PM2.5) four seasons both 2015–2016 2018–2019 at an urban site Shanghai, China, comprehensively...
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing to compare IAV H7N9 patients with healthy controls and observed strong association infection rare, heterozygous single-nucleotide variants in the MX1 gene. codes myxovirus resistance protein (MxA), an interferon-induced antiviral guanosine triphosphatase known control transgenic mice. Most MxA...
The recent rise in the frequency of influenza A(H5N6) infections China has raised serious concerns about whether risk for human infection increased. We surveyed epidemiologic, clinical, and genetic data with viruses. Severe disease occurred 93.8% cases, fatality rate was 55.4%. Median patient age 51 years. Most H5N6 hemagglutinin (HA) genes isolates 2021 originated from subclade 2.3.4.4b; we estimated time to most common ancestor as June 16, 2020. A total 13 genotypes HA multiple subclades...
Here, we deploy a Gothenburg potential aerosol mass reactor (Go:PAM) to investigate the secondary organic (SOA) formation from Chinese domestic cooking emissions. Volatile compounds (VOCs) and semivolatile/intermediate-volatility (S/IVOCs) were measured by Vocus proton transfer reaction time-of-flight spectrometer (Vocus PTR-TOF). SOA was calculated particle number size distribution density that centrifugal analyzer. The primary aerosols (POA) emission rates are 2.0, 2.2, 1.8, 1.1 mg min–1...
Polypeptide vaccines have the potential to improve immune responses by targeting conserved and weakly immunogenic regions in antigens. This study aimed identify evaluate efficacy of a novel influenza universal vaccine candidate consisting multiple polypeptides derived from highly virus proteins hemagglutinin (HA), neuraminidase (NA), matrix protein 2 (M2). Immunoinformatics tools were used screen epitopes different subtypes (H1N1, H3N2, H5N1, H7N9, H9N2, IBV). A polypeptide vaccine, P125-H,...
During the epidemic period of novel H7N9 viruses, an influenza A (H9N2) virus was isolated from a 7-year-old boy with influenza-like illness in Yongzhou city Hunan province November 2013. To identify possible source infection, environmental specimens collected local live poultry markets epidemiologically linked to human case were tested for type and its subtypes H5, H7, H9 using real-time RT-PCR methods as well isolation, four other H9N2 viruses isolated. The results showed that environment...
A novel avian influenza A(H7N9) virus causing human infection emerged in February 2013 China. To elucidate the mechanism of interspecies transmission, we compared signature amino acids viruses from and non-human hosts analysed reassortants 146 with full genome sequences. We propose a genetic tuning procedure continuous acid substitutions reassorting that mediates host adaptation transmission. When early virus, containing ancestor haemagglutinin (HA) neuraminidase (NA) genes similar to...