A5052173824- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Fire effects on ecosystems
- Viral Infections and Outbreaks Research
- Monoclonal and Polyclonal Antibodies Research
- Vector-borne infectious diseases
- Animal Virus Infections Studies
- Selenium in Biological Systems
- Air Quality and Health Impacts
- Vector-Borne Animal Diseases
- COVID-19 diagnosis using AI
- Fungal Biology and Applications
- Asthma and respiratory diseases
- Biosensors and Analytical Detection
- Trace Elements in Health
- Dermatological and COVID-19 studies
- vaccines and immunoinformatics approaches
Anhui Provincial Center for Disease Control and Prevention
2014-2025
Jiangsu Normal University
2011-2025
Northeast Agricultural University
2024
Zhejiang Chinese Medical University
2024
Health Commission of Anhui Province
2024
Tsinghua University
2021
Anhui Medical University
2019-2021
Renmin University of China
2020
BC Innovation Council
2019
Beijing Tongren Hospital
2015
To date, SARS-CoV-2 has caused tremendous loss of human life and economic output worldwide. Although a few COVID-19 vaccines have been approved in several countries, the development effective therapeutics, including targeting antibodies, remains critical.
A novel avian influenza A(H7N9) virus causing human infection emerged in February 2013 China. To elucidate the mechanism of interspecies transmission, we compared signature amino acids viruses from and non-human hosts analysed reassortants 146 with full genome sequences. We propose a genetic tuning procedure continuous acid substitutions reassorting that mediates host adaptation transmission. When early virus, containing ancestor haemagglutinin (HA) neuraminidase (NA) genes similar to...
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has been confirmed altering viral antigenicity resulting immune escape. To identify crucial mutations that escape humoral response, we evaluated cross-neutralization convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various protein-based pseudoviruses. Three 24 pseudoviruses containing different protein, including...
Abstract Salmonella is widely known as one of the most common foodborne pathogens, and antibiotics remain effective in clinical therapies against its infections. To guide better antibiotic treatment, we analyzed antimicrobial resistance (AMR) profiles a nation-wide collection 36,822 isolates derived from sporadic diarrhea cases China 2014 to 2021. A panel 15 antibiotics, including 10 critically important 5 highly agents for human medicine based on WHO CIA List, was selected AMR surveillance....
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is sweeping the world since end of 2019. The titer change antibodies against SARS‐CoV‐2 needs to be further clarified, clinical and preventive value still investigated. An enzyme‐linked immunosorbent assay (ELISA) was established by coating with recombinant spike protein used detect serum immunoglobulin M (IgM) G (IgG) in disease 2019 patients evaluate pattern changes antibodies. specificity ELISA for detection IgM IgG...
Early targeted antibiotic therapy is crucial for improving the prognosis of immunocompromised patients with severe respiratory infections (SRIs) in intensive care unit (ICU). Metagenomic next-generation sequencing (mNGS) has shown significant value pathogen detection, but research on lower tract microorganisms remains limited. This study enrolled 234 SRIs ICU, and individuals were categorized into immunocompetent groups. We compared diagnostic performance mNGS using bronchoalveolar lavage...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of has been documented, but mechanisms require further investigation. Epidemiological investigations and genetic analyses patients were conducted, a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission. According epidemiologic investigations, 14 secondary cases had clear history...
An increasing number of critically ill patients are immunocompromised. These at high risk intensive care unit (ICU) admission because numerous complications. Acute respiratory failure due to severe community-acquired pneumonia (SCAP) is one the leading causes admission. Early targeted antibiotic therapy crucial for improving prognosis these patients. Metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF) has shown significant value pathogen detection recent...
Introduction Klebsiella michiganensis , a significant member of the oxytoca complex, has emerged as potential pathogen in clinical settings. Despite extensive research on pneumoniae pathogenicity and drug resistance K. complex remain understudied, particularly regarding reconstruction whole genomes from metagenomic next-generation sequencing (mNGS) data. Methods In this study, bronchoalveolar lavage fluid (BALF) 55-year-old woman with suspected right lung infection Anhui Province, China, was...
Abstract Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report phylogenetic group S. with extensive drug resistance, including combination multidrug coresistance to ceftriaxone and azithromycin (cef R azi ), reduced susceptibility fluoroquinolones, even colistin (col ). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 2020. We collect 155 outbreak isolates 152 sporadic isolates. The cef isolates, strains, are mainly...
Inonotus obliquus (Pers.:Fr.) Pilat has been traditionally used as a folk remedy for treatment of cancers, cardiovascular disease and diabetes in Russia, Poland, most the Baltic countries, but natural reserves this fungus have nearly exhausted. This study was designed to investigate artificial cultivation I. antitumor activity its tissues. The ethanol extract cultivated sclerotium had highest cell growth inhibitory rate (74.6%) determined by an 3-(4, 5-dimethylthiazol-2-yl)-2,...
The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several clinically used "old" drugs have been repurposed to this disease urgent clinical investigation, there is still great demand more effective therapies anti-infections. Here we report discovery that an Emetine could potently inhibit SARS-CoV-2 virus replication and displayed entry blocking effect in Vero cells at low dose. In addition, significantly...
Coronavirus disease 2019 (COVID-19) remains a serious emerging global health problem, and little is known about the role of oropharynx commensal microbes in infection susceptibility severity. Here, we present oropharyngeal microbiota characteristics identified by full-length 16S rRNA gene sequencing through NANOPORE platform swab specimens from 10 mild COVID-19 patients healthy controls. Our results revealed distinct composition patients, characterized enrichment opportunistic pathogens such...
In this population-based study, we identified 307 confirmed COVID-19 cases from massive surveillance, including 129 551 individuals screened at fever clinics or returning Hubei and 3710 close contacts of patients. Among them, 17 patients were asymptomatic initial clinical assessment. These on admission accounted for a small proportion all (5.54%) with relatively weak transmissibility, the detection rate was 0.35 per 100 contacts. Moreover, dynamics symptoms showed that interval symptom...
Abstract The emergence of mobilized colistin resistance ( mcr ) genes has raised significant concerns as they pose a public health issue. prevalence genes, particularly the newly discovered mcr-9 gene, in non-typhoidal Salmonella (NTS) isolates remains unclear. We characterized mcr-9.1 -producing NTS from China. Among 7,106 diarrhea cases 32 provinces during 2010–2020, 11 were identified and all not resistant to colistin. Five belonged Thompson sequence type (ST) 26, two Typhimurium ST34,...
H10 avian influenza viruses circulate in wild birds and can reassort with other subtypes. H10N8 H10N3 have previously caused sporadic human infections China.
Introduction Animal waste proteins have been increasing in the past decade, along with consumer demands. Their huge volume and environmental issues caused by improper treatment probably pose a massive threat to human health. These animal contain many valuable bioactive peptides can be used not only as nutrient substances but also primary functional ingredients industries, including agriculture, food, pharmaceuticals. However, advancement of value-added application within 10 years has...
The spike trimer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective target for inducing neutralizing antibodies by disease 2019 (COVID-19) vaccines. However, the diversity protein from emerging SASR-CoV-2 variants has become major challenge development a universal vaccine. To investigate immunogenicity proteins various circulating strains including wild type, Delta, and Omicron variants, we produced natural trimers designed three vaccination strategies, that is,...