A5109812784- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Enzyme Structure and Function
- Enzyme Production and Characterization
- Genomics and Phylogenetic Studies
- Amino Acid Enzymes and Metabolism
- Microbial bioremediation and biosurfactants
- Microbial Metabolites in Food Biotechnology
- Catalysis and Hydrodesulfurization Studies
- COVID-19 Clinical Research Studies
- Bacterial Genetics and Biotechnology
- Probiotics and Fermented Foods
- SARS-CoV-2 and COVID-19 Research
- biodegradable polymer synthesis and properties
- CRISPR and Genetic Engineering
- SARS-CoV-2 detection and testing
- Microbial Community Ecology and Physiology
- Cancer Research and Treatments
- Fungal and yeast genetics research
- Listeria monocytogenes in Food Safety
- Food composition and properties
- Biopolymer Synthesis and Applications
- Salmonella and Campylobacter epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
Chinese Academy of Sciences
2016-2025
State Key Laboratory of Mycology
2019-2025
Qingdao Institute of Bioenergy and Bioprocess Technology
2025
Institute of Microbiology
2016-2025
Guangxi University
2025
Czech Academy of Sciences, Institute of Microbiology
2007-2025
Nanchang University
2013-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Second Affiliated Hospital of Nanchang University
2024
Zhengzhou University
2024
The outbreak of COVID-19 caused a worldwide public health crisis. Large-scale population screening is an effective means to control the spread COVID-19. Reverse transcription–polymerase chain reaction (RT-qPCR) and serology assays are most available techniques for SARS-CoV-2 detection; however, they suffer from either less sensitivity accuracy or low instrument accessibility screening. To balance sensitivity, specificity, test availability, here, we developed enhanced colorimetry, which...
Heterogeneous metallaphotocatalytic chemical transformations employing a recyclable catalyst are highly desirable for organic synthesis. However, the rational design and controlled preparation of well-defined, site-isolated metal/photo bifunctional heterogeneous catalysts to achieve this goal remain significant challenge. In study, we demonstrate covalent attachment homogeneous molecular MnSalen complex (where Salen = N,N′-bis(salicylidene)ethylenediamine) onto surface graphitic carbon...
The high mutation rate of COVID-19 and the prevalence multiple variants strongly support need for pharmacological options to complement vaccine strategies. One region that appears highly conserved among different genera coronaviruses is substrate-binding site main protease (Mpro or 3CLpro), making it an attractive target development broad-spectrum drugs coronaviruses. PF-07321332, developed by Pfizer, first orally administered inhibitor targeting SARS-CoV-2, which also has shown potency...
Compared with spring tea, summer tea has the advantages of economy and quantity. However, research on aroma characteristics is currently limited. In this study, fresh leaves (castanopsis. sinensis, cv. Fuliangzhong) (FTLs) were processed intoblack (BT) green (GT). The changes in volatile compounds during processing quantified using gas chromatography-ion mobility spectrometry (GC-IMS) head space-solid phase micro-extraction chromatography-mass (HS-SPME-GC-MS), then analyzed basis relative...
To study the effect of storage (for 0, 3, 6, and 12 months) on flavor green tea (GT), we monitored volatile organic compounds (VOCs) in GT through gas chromatography (GC) combined with ion mobility spectrometry headspace solid-phase micro extraction, GC-MS (mass spectrometry). Then, relative odor activity value (ROAV) was applied to analyze aroma contribution VOCs. During storage, polyphenol caffeine contents gradually decreased from 22.38 % 18.51 4.37 3.74 %, respectively, total soluble...
Food contaminated by mycotoxins has become a worldwide public problem with political and economic implications. Although variety of traditional methods have been used to eliminate from agri-foods, the results somewhat less than satisfactory. As an emerging non-thermal processing technology, atmospheric cold plasma (ACP) great potential for food decontamination. Herein, this review mainly presents degradation efficiency ACP on in vitro agri-foods as well its possible mechanisms. Meanwhile,...
Arsenic (As) is a highly toxic chemical element associated with cardiovascular diseases and diabetes. Using genetically modified microorganisms (GMOs) for arsenic detoxification or removal taking center stage in recent years. However, the bio-safety issue of GMOs remains an obstacle. In this study, we proposed bioremediation process to efficiently adsorb from mining wastewater by combining controllable GMO biochar. One metagenomic gene (ArsR) high adsorption efficiency was newly identified...
ABSTRACT The soil-isolated strain XP was identified as Rhodococcus erythropolis. R. erythropolis could efficiently desulfurize benzonaphthothiophene, a complicated model sulfur compound that exists in crude oil. desulfurization product of benzonaphthothiophene α-hydroxy-β-phenyl-naphthalene. Resting cells diesel oil (total organic sulfur, 259 ppm) after hydrodesulfurization. content reduced by 94.5% using the resting cell biocatalyst for 24 h at 30°C. Biodesulfurization oils also...
The demand for lactic acid has been increasing considerably because of its use as a monomer the synthesis polylactic (PLA), which is promising and environment-friendly alternative to plastics derived from petrochemicals. Optically pure L-lactic essential polymerization PLA. high fermentation cost another limitation PLA polymers compete with conventional plastics.A Bacillus sp. strain 2-6 production was isolated at 55 degrees C soil samples. Its thermophilic characteristic made it good...
Chlorophenols are environmental contaminants, which highly toxic to living beings due their carcinogenic, mutagenic and cytotoxic properties. Bacterial degradation has been considered a cost-effective eco-friendly method of removing chlorophenols, compared the traditional physical–chemical processes. In this study, we first developed an efficient process for biodegradation chlorophenols by magnetically immobilized Rhodococcus rhodochrous cells. R. DSM6263 degrades following step...
Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration NMN reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus, attracting much attention promising nutraceutical. Here, we engineered Escherichia coli strain produce from cheap substrate nicotinamide (NAM) glucose. supply in vivo precursor phosphoribosyl pyrophosphate (PRPP) ATP was enhanced by strengthening...
Hazardous materials, such as heavy metals, are the major sources of health risk. Using genetically modified organisms (GMOs) to dispose metals has advantages strong environmental compatibility and high efficiency. However, biosecurity GMOs used in environment is a concern. In this study, self-controlled genetic circuit was designed carefully fine-tuned for programmable expression Pseudomonas putida KT2440, which widely strain bioremediation. The cell behaviours were controlled by...
Abstract Salmonella is widely known as one of the most common foodborne pathogens, and antibiotics remain effective in clinical therapies against its infections. To guide better antibiotic treatment, we analyzed antimicrobial resistance (AMR) profiles a nation-wide collection 36,822 isolates derived from sporadic diarrhea cases China 2014 to 2021. A panel 15 antibiotics, including 10 critically important 5 highly agents for human medicine based on WHO CIA List, was selected AMR surveillance....
l-Lactic acid (l-LA) is a platform chemical obtained via microbial fermentation at near-neutral pH value. Large amounts of neutralizers are required during this process, which increases the production costs in downstream processing as well environmental burden. To address challenge, an acid-tolerant yeast Pichia kudriavzevii E1 was isolated and metabolically engineered to produce l-LA without neutralizers. The genome strain sequenced CRISPR-Cas9 system developed newly strain. Subsequently,...