A5057100441- Microbial Community Ecology and Physiology
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pharmaceutical and Antibiotic Environmental Impacts
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Mercury impact and mitigation studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Gastric Cancer Management and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Heavy metals in environment
- Landfill Environmental Impact Studies
- Cancer Cells and Metastasis
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Acute Myeloid Leukemia Research
- Birth, Development, and Health
- Wastewater Treatment and Nitrogen Removal
- Intracerebral and Subarachnoid Hemorrhage Research
- Anaerobic Digestion and Biogas Production
- Mechanisms of cancer metastasis
Sichuan University
2015-2025
Zhujiang Hospital
2025
Southern Medical University
2004-2025
University of Science and Technology of China
2025
Chengdu University of Traditional Chinese Medicine
2025
Bengbu Medical College
2025
Ollscoil na Gaillimhe – University of Galway
2024
State Key Laboratory of Biotherapy
2017-2024
Nanning Normal University
2022-2024
Second Xiangya Hospital of Central South University
2007-2024
Abstract Cancer-associated fibroblasts (CAFs) are the predominant components of tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different types. Here, we perform pan-cancer analysis 226 samples 10 solid types to profile TME at single-cell resolution, illustrating commonalities/plasticity heterogenous CAFs. Activation trajectory major CAF is divided into three states, exhibiting distinct interactions...
Abstract Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available remove clot, and mechanism of neuronal death during ischemic is still in debate. Ferroptosis increasingly appreciated as cell after ischemia various organs. Here we report that serine protease, thrombin, instigates ferroptotic signaling by promoting arachidonic acid mobilization subsequent esterification gene, acyl-CoA synthetase long-chain family member 4...
Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due their high specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment some malignant tumors a promising therapeutic modality. Lung cancer is lethal disease with the highest morbidity mortality rate world. Despite rapid development targeted therapy immune checkpoint inhibitors for lung recent years, efficacy still unsatisfactory overall. Therefore,...
Clinical staining and targeting CREB3L1 facilitates precise stratification a potential treatment strategy for thyroid cancer.
Many differences between different ethnic groups have been observed, such as skin color, eye height, susceptibility to some diseases, and response certain drugs. However, the genetic bases of under-investigated. Since HapMap project, large-scale genotype data from Caucasian, African Asian population samples available. The project found that these populations were located in areas PCA (Principal Component Analysis) plot. an unsupervised method, does not measure each single nucleotide...
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
As a widely used anticancer and immunosuppressive agent, methotrexate (MTX) can induce multiple adverse drug reactions (ADRs), such as gastrointestinal toxicity, the mechanisms are poorly understood. Gut microbiota has been reported to be associated with onset of diseases well treatment outcomes different drugs. In this study, mucosal injury was observed in MTX-treated mice, leading significant changes macrophages (i.e., M1/M2 ratio, P < 0.05) but not dendritic cells. Moreover, population,...
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns metastasis without systematical genomic investigation. Here, we evaluated evolution CRC with multiorgan metastases using multiregion sequencing. Design Whole-exome sequencing was performed on multiple regions (n=74) matched primary tumour, adjacent non-cancerous mucosa, liver lung from six patients CRC. Phylogenetic reconstruction evolutionary analyses were used to...
Abstract Methylmercury formation is mainly driven by microbial-mediated process. The mechanism of microbial mercury methylation has become a crucial research topic for understanding in the environment. Pioneering studies are focusing on functional strain isolation, community composition characterization, and elucidation various environments. Therefore, genes methylation, global isolations Hg strains, their potential were systematically analyzed, methylators typical environments extensively...
A novel avian influenza A(H7N9) virus causing human infection emerged in February 2013 China. To elucidate the mechanism of interspecies transmission, we compared signature amino acids viruses from and non-human hosts analysed reassortants 146 with full genome sequences. We propose a genetic tuning procedure continuous acid substitutions reassorting that mediates host adaptation transmission. When early virus, containing ancestor haemagglutinin (HA) neuraminidase (NA) genes similar to...
Through a national surveillance system for unexplained pneumonia, severe case of influenza A(H7N9) in man his mid-30s was identified Zhejiang Province, China on 14 October 2013. Epidemiological and clinical findings were consistent with the patterns reported during outbreak spring 2013, laboratory showed that virus had 99.6% identity earlier H7N9 viruses humans except five mutations NA gene.
The genomic alterations for benign thyroid nodule, especially adenomatoid one of the most common types hyperplasia lesion, are ill-studied. Here, we show whole-exome sequencing and/or transcriptome data on nodules with or without coincidental papillary carcinoma (PTC). Somatic mutation BRAF (22/32) is only detected in PTC, while mutations SPOP (4/38), ZNF148 (6/38) and EZH1 (3/38) found enriched nodule. In an expanded cohort nodule (n=259) mutually exclusive SPOPP94R, EZH1Q571R identified...
Non-small-cell lung cancer (NSCLC) has been recognized as a highly heterogeneous disease with phenotypic and genotypic diversity in each subgroup. While never-smoker patients NSCLC have well studied through next generation sequencing, we yet to recognize the potentially unique molecular features of young NSCLC. In this study, conducted whole genome sequencing (WGS) characterize genomic alterations 36 Chinese patients, who were diagnosed adenocarcinoma (LUAD) at 45 years or younger. Besides...
Development of personalized cancer vaccines based on neoantigens has become a new direction in immunotherapy. Two forms have been widely studied: tumor-associated antigen (including proteins, peptides, or tumor lysates)-pulsed dendritic cell (DC) and protein- peptide-adjuvant vaccines. However, different immune modalities may produce therapeutic effects responses when the same is used. Therefore, it necessary to choose more effective neoantigen vaccination method. In this study, we compared...
Bioenergetic reprogramming during hypoxia adaption is critical to promote hepatocellular carcinoma (HCC) growth and progression. However, the mechanism underlying orchestration of mitochondrial OXPHOS (oxidative phosphorylation) glycolysis in not fully understood. Here, we report that UQCC3 (C11orf83) expression increases correlates with poor prognosis HCC patients. Loss impairs cell proliferation vitro vivo. Mechanistically, forms a positive feedback loop reactive oxygen species (ROS)...
The occurrence and prevalence of colorectal cancer (CRC) is closely associated with age. More than 90% patients CRC are diagnosed after 50 years However, incidence young individuals has been increasing since 1990s, whereas the overall frequency declining. Distinct survival rates between aged have established. Tremendous efforts made to clarify underlying mechanisms age-dependent clinical differences, but it still remains elusive. Here, we performed proteomic profiling revealed signatures...