A5100378142- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- HER2/EGFR in Cancer Research
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Childhood Cancer Survivors' Quality of Life
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Ginseng Biological Effects and Applications
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Pharmacological Effects of Natural Compounds
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- TGF-β signaling in diseases
- Gastrointestinal Tumor Research and Treatment
Hunan University of Traditional Chinese Medicine
2025
Guangdong Pharmaceutical University
2025
Wuhu Fourth People Hospital
2024
St. Jude Children's Research Hospital
2023-2024
Third People's Hospital of Hangzhou
2024
West China Hospital of Sichuan University
2009-2023
University of Calgary
2017-2023
University of Alberta
2017-2023
Sichuan University
2009-2023
Army Medical University
2012-2023
<h3>Importance</h3> We previously showed that detection of androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs) from men with castration-resistant prostate cancer (CRPC) was associated primary resistance to enzalutamide and abiraterone therapy, but the relevance AR-V7 status context chemotherapy is unknown. <h3>Objective</h3> To investigate whether AR-V7–positive patients would retain sensitivity taxane have a differential impact on taxane-treated compared...
Clinical staining and targeting CREB3L1 facilitates precise stratification a potential treatment strategy for thyroid cancer.
Objective Using data from NHANES 2007–2018, to examine the association between WWI (weight-adjusted waist index) index and prevalence of kidney stones. Methods multiple logistic regression analysis National Health Nutrition Examination Survey (NHANES) we evaluated stones, followed by subgroup sensitive populations. Smooth curve fitting was used determine whether there a non-linear relationship stone prevalence, threshold effect test this relationship. Results Among 29,280 participants, 2,760...
This study aimed to assess the effect of long noncoding RNAs (lncRNAs) taurine-upregulated gene 1 (TUG1) on cells proliferation and apoptosis as well its targeting genes in epithelial ovarian cancer (EOC) cells.Blank mimic, lncRNA TUG1 blank inhibitor, inhibitor plasmids were transfected into SK-OV-3 (SKOV3) cells. Rescue experiment was performed by transfection Aurora kinase A (AURKA) mimic SKOV3 Cell counting kit-8 (CKK-8), annexin V-FITC (AV)-propidium iodide (PI) (AV-PI), quantitative...
Metagenome next-generation sequencing (mNGS) is a valuable diagnostic tool that can be used for the identification of early pathogens acute respiratory distress syndrome (ARDS) in severe pneumonia. Little known about use this technology clinical application and evaluation prognostic value ARDS.We performed retrospective cohort study patients with ARDS caused by Samples were collected from intensive care unit (ICU) Jiangmen Central Hospital January 2018 to August 2019. The no-next generation...
BACKGROUND Neuroblastoma survivors may be at elevated risk for psychological impairments because of their young age diagnosis and neurotoxic treatment, but this is not well described. METHODS A total 859 ≥5‐year neuroblastoma younger than 18 years (diagnosed in 1970‐1999), who had a median 0.8 (range: 0.0‐7.3 years) follow‐up 13.3 8.0‐17.9 years), were compared with 872 siblings childhood cancer the parent‐reported Behavior Problem Index (BPI) functioning. Age‐ sex‐adjusted multivariate...
Ferroptosis is caused by accumulation of iron-dependent lipid peroxidation, which characterized reduction in cell volume and increase mitochondrial membrane density. Studies have shown that ferroptosis contributes to the development progression numerous major diseases, including hepatocellular carcinoma (HCC). As a unique biomedical resource, Traditional Chinese Medicine (TCM) has been widely used treatment HCC. In this present study, Scutellaria barbata was treat HCC cells vitro , results...
Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or stress-activated protein kinases. Herein we report on identification a novel p53 target gene (A28-RGS14) is induced in response genotoxic stress encodes member family regulators signaling (RGS) with proposed GTPase-activating activity. Overexpression A28-RGS14p inhibits both i - q -coupled growth-factor-receptor-mediated kinase...
A series of ligustrazine platinum( iv ) complexes were developed, which displayed potent anti-proliferative and anti-metastatic activities by causing DNA damage, mitochondrial pro-death autophagy activating immune response.
Mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutation due the high rate of reactive oxygen species (ROS) production limited DNA-repair capacity in mitochondrial. Previous studies demonstrated that increased mtDNA copy number for compensation damage, which was associated with cigarette smoking, has been found be lung cancer risk among heavy smokers. Given common "non-pathological" variations determine differences phosphorylation performance ROS production, an...
Dysregulated RNA processing is crucial in nasopharyngeal carcinoma (NPC) progression. Our research aimed to evaluate the prognostic values of RNA-processing genes (RPGs) NPC through bioinformatic analysis GSE12452 and GSE102349 datasets, identifying differentially expressed (DE-RPGs). A model was developed using univariate multivariate Cox analysis, with effectiveness assessed by ROC analysis. The correlation between risk scores, immune characteristics, chemotherapy sensitivity also...
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that plays critical role in modulating immune response and inflammation. We employed the Affymetrix cDNA microarray system to detect genes whose expression regulated by TGF-β1 human T cell line HuT78. Tristetraprolin (TTP), protein involved degradation of tumor necrosis factor-α (TNF-α) mRNA, was found be up-regulated TGF-β. This up-regulation confirmed reverse transcriptase-PCR analysis revealed rapid transient induction TTP...
Unchecked epithelial cell death is fundamental to the pathogenesis of pneumonia. The recognition unique signaling pathways that preserve viability may present new opportunities for interventional strategies. We describe mortality factor 4 like 1 (Morf4l1), a protein involved in chromatin remodeling, constitutively expressed at low levels lung because its continuous degradation mediated by an orphan ubiquitin E3 ligase subunit, Fbxl18. Expression Morf4l1 increases humans with pneumonia and...
5001 Background: Androgen receptor splice variant-7 (AR-V7) is a truncated form of the androgen that lacks ligand-binding domain, target enzalutamide and abiraterone, but remains constitutively active as transcription factor. We hypothesized detection AR-V7 in circulating tumor cells (CTCs) from men with mCRPC may be associated primary resistance to abiraterone. Methods: used quantitative reverse-transcription PCR (qRT-PCR) interrogate CTCs for presence or absence prospectively enrolled...