A5045356053- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Heavy Metal Exposure and Toxicity
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Air Quality and Health Impacts
- Pregnancy and preeclampsia studies
- Trace Elements in Health
- Sepsis Diagnosis and Treatment
- S100 Proteins and Annexins
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Hedgehog Signaling Pathway Studies
- Reproductive System and Pregnancy
- COVID-19 and healthcare impacts
- Noise Effects and Management
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
Second Hospital of Anhui Medical University
2019-2025
Anhui Medical University
2016-2025
Second Hospital of Shandong University
2025
Peking University
2025
Peking University Third Hospital
2025
First Affiliated Hospital of Bengbu Medical College
2024
Clinical Trial Investigators
2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2024
Chinese Academy of Sciences
2013-2022
Vitamin D deficiency is common in pregnant women. Nevertheless, the association between maternal vitamin status during pregnancy and risk of having small for gestational age (SGA) low birth weight (LBW) infants uncertain. The objective this study was to investigate whether there a correlation SGA LBW Chinese population. This population-based cohort that recruited 3658 eligible mother-and-singleton-offspring pairs. Serum 25-hydroxyvitamin measured by RIA. rate relative (RR) were calculated...
Abstract We investigated the association between maternal zinc level during pregnancy and risks of low birth weight (LBW) small for gestational age (SGA) infants in a large population-based cohort study. In this study, 3187 pregnant women were recruited. For serum level, 2940 sufficient (≥56 μg/dL) 247 deficient (<56 μg/dL). Of interest, 7.3% newborns with LBW among subjects ( RR : 3.48; 95% CI 2.03, 5.96; P < 0.001). Adjusted was 3.41 (95% 1.97, 5.91; 0.001) level. Moreover, 15.0% SGA...
The goal of this study was to analyze whether mitochondria-associated endoplasmic reticulum membrane (MAMs) dysfunction mediated arsenic (As)-evoked pulmonary ferroptosis and acute lung injury (ALI). As exposure led alveolar structure damage, inflammatory cell infiltration function decline in mice. Ferritin, the marker iron overload, increased, GPX4, index lipid peroxidation, decreased As-exposed lungs epithelial cells (MLE-12). Pretreatment with ferrostatin-1 (Fer-1), inhibitor ferroptosis,...
Abstract It is increasingly recognized that vitamin D3 (VitD3) has an anti-inflammatory activity. The present study investigated the effects of maternal VitD3 supplementation during pregnancy on LPS-induced placental inflammation and fetal intrauterine growth restriction (IUGR). All pregnant mice except controls were intraperitoneally injected with LPS (100 μg/kg) daily from gestational day (GD)15–17. In + group, orally administered (25 before injection. As expected, exposure caused IUGR....
Data are limited on the impact of neuraminidase inhibitor (NAI) treatment avian influenza A(H7N9) virus RNA shedding.In this multicenter, retrospective study, data were collected from adults hospitalized with infection during 2013-2017 in China. We compared clinical features and shedding among patients different NAI doses combination therapies evaluated factors associated shedding, using Cox proportional hazards regression.Among 478 patients, median age was 56 years, 71% male, 37% died. The...
Through a national surveillance system for unexplained pneumonia, severe case of influenza A(H7N9) in man his mid-30s was identified Zhejiang Province, China on 14 October 2013. Epidemiological and clinical findings were consistent with the patterns reported during outbreak spring 2013, laboratory showed that virus had 99.6% identity earlier H7N9 viruses humans except five mutations NA gene.
Hedgehog signaling plays very important roles in development and cancers. Vertebrates have three transcriptional factors, Gli1, Gli2 Gli3. Among them, Gli3 is a special factor which closely resembles Cubitus interruptus (Ci, Drosophila) structurally functionally as ‘double agent’ for Shh target gene expression. Here we show that full-length, but not the truncated form, can be methylated at K436 K595. This methylation specifically catalyzed by Set7, lysine methyltransferase (KMT). Methylation...
Abstract Background Coronavirus disease 2019 (COVID-19) triggered by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been widely pandemic all over the world. The aim of this study was to analyze influence factors death risk among 200 COVID-19 patients. Methods Two hundred patients confirmed SARS-CoV-2 were recruited. Demographic data and clinical characteristics collected from electronic medical records. Biochemical indexes on admission measured patient’s...
Vitamin D deficiency is associated with increased risks of chronic obstructive pulmonary disease (COPD). Nevertheless, the mechanisms remain unknown. This study analyzed correlations between vitamin levels and inflammation in COPD patients. One hundred one patients 202 control subjects were enrolled. Serum 25(OH)D level inflammatory cytokines detected. was decreased According to forced expiratory volume 1 s, divided into three grades. Furthermore, serum gradually ranging from grade 1-2 4....
Abstract Coronavirus disease 2019 (COVID-19) is a newly emerged infection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has been pandemic all over the world. This study described kidney injury (AKI) at early stage COVID-19 its clinical significance. Three-hundred fifty-five patients with were recruited data collected from electronic medical records. Patient’s prognosis was tracked risk factors AKI analyzed. Of 355 patients, common, critical ill cases accounted for...
Vitamin D deficiency is correlated with the increased morbidity of chronic obstructive pulmonary disease (COPD). However, mechanisms underlying these effects have largely remained elusive. This study analyzed correlations among COPD, vitamin concentration, and epithelial-mesenchymal transition (EMT). Ninety-five patients newly diagnosed COPD 190 age- sex-matched healthy subjects were recruited for this research. Serum 25(OH)D levels detected, EMT biomarkers TGF-β/Smad signaling evaluated....
Abstract Introduction Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced dysfunction with prognosis remains obscure. Materials and methods All 154 patients COVID-19 were recruited from Second People’s Hospital Fuyang City in Anhui, China. Demographic characteristics laboratory data extracted. Renal was evaluated its followed up based on a...
Abstract The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. present study evaluated serum Cd level small for gestational age (SGA) infants in a Chinese population. analyzed subsample C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal was measured by graphite furnace atomic absorption spectrometry. rate odds ratio ( OR ) SGA infant were calculated. 10.6%...
Abstract Low vitamin D status is associated with progression in patients renal cell carcinoma (RCC). The present study found that vimentin, a mesenchymal marker, was accordingly upregulated, and E‐cadherin, an epithelial downregulated RCC low status. Thus, we investigated the effects of calcitriol or D3, active form D, on epithelial‐mesenchymal transition (EMT) cells. cells were treated by two models. In model 1, three lines, ACHN, 786‐O CAKI‐2, incubated either LPS (2.0 μg/mL) transforming...
Environmental cadmium (Cd) exposure can cause several pulmonary diseases. Epithelial-mesenchymal transition (EMT) involved in the process of chronic obstructive disease (COPD). However, association between environmental Cd and EMT was unclear COPD patients. This study aimed to analyze associations among circulatory Cd, based on case-control study. Four hundred patients 400 control subjects were recruited. Circulatory detected using atomic adsorption spectrometer. MicroRNA-30 (miR-30)...
Environmental cadmium (Cd) exposure is linked to pulmonary function injury in the general population. But, association between blood Cd concentration and has not been investigated thoroughly chronic obstructive disease (COPD) patients, potential mechanisms are unclear.All eligible 789 COPD patients were enrolled from Anhui cohort. Blood specimens clinical information collected. Pulmonary test was conducted. The subunit of telomerase, telomerase reverse transcriptase (TERT), determined...
Prior studies in patients with chronic obstructive pulmonary disease (COPD) had indicated a potential correlation between cadmium (Cd) exposure and reduction lung function. Nevertheless, the influence of Cd on progression COPD remained unknown. Exploring relationship was aim this investigation.