A5100724106- Cardiovascular Function and Risk Factors
- Histone Deacetylase Inhibitors Research
- Metabolism, Diabetes, and Cancer
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
- COVID-19 and healthcare impacts
- Peptidase Inhibition and Analysis
- Pneumonia and Respiratory Infections
- Pancreatic and Hepatic Oncology Research
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Explainable Artificial Intelligence (XAI)
- Immunodeficiency and Autoimmune Disorders
- Pancreatitis Pathology and Treatment
- Bone Metabolism and Diseases
- Coenzyme Q10 studies and effects
- Advanced Graph Neural Networks
- Pancreatic function and diabetes
- Domain Adaptation and Few-Shot Learning
Guangzhou University of Chinese Medicine
2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
University of Electronic Science and Technology of China
2024
Stevens Institute of Technology
2024
Hebei Medical University
2022
Second Hospital of Hebei Medical University
2022
Second Hospital of Anhui Medical University
2021
Anhui Medical University
2020-2021
First Hospital of Jilin University
2015-2020
Abstract Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed facilities have endeavored to mitigate pandemic, but mortality COVID-19 continues increase. Here, we present a risk prediction model for (MRPMC) that uses patients’ clinical data on admission stratify patients by risk, which enables physiological deterioration and death up 20 days in advance. This ensemble is built using four machine learning methods including Logistic Regression,...
We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription factor erythroid 2–related (Nrf2) metallothionein (MT). In this study, we tested whether SFN protects heart from T2DM directly through Nrf2, MT, or both. Using Nrf2-knockout (KO), MT-KO, wild-type (WT) mice, was induced by feeding a high-fat diet for 3 months followed small dose streptozotocin. Age-matched controls were...
In modern software development and operations, DevOps (a combination of operations) has become a key methodology aimed at accelerating delivery, improving quality enhancing security. Meanwhile, artificial intelligence (AI) machine learning (ML) are also playing an increasingly important role in cybersecurity, helping to identify respond complex threats. this article, we'll explore how AI ML can be integrated into practices ensure the security operations processes. We'll cover best practices,...
Inhibition of total histone deacetylases (HDACs) was phenomenally associated with the prevention diabetic cardiomyopathy (DCM). However, which specific HDAC plays key role in DCM remains unclear. The present study designed to determine whether can be prevented by inhibition HDAC3 and elucidate mechanisms prevents DCM. Type 1 diabetes OVE26 age-matched wild-type (WT) mice were given selective inhibitor RGFP966 or vehicle for 3 months. These then killed immediately months later cardiac...
The ferocious global assault of COVID-19 continues. Critically ill patients witnessed significantly higher mortality than severe and moderate ones. Herein, we aim to comprehensively delineate clinical features explore risk factors developing critical disease.This is a Mini-national multicenter, retrospective, cohort study involving 2,387 consecutive inpatients that underwent discharge or death between January 27 March 21, 2020. After quality control, 2,044 were enrolled. Electronic medical...
Glioblastomas multiforme (GBM) are the most frequently occurring malignant brain cancers. Treatment for GBM consists of surgical resection and subsequent adjuvant radiation therapy chemotherapy. Despite this, patient survival is limited to 12-15 months, researchers continually trying develop improved options. Insulin-like growth factor 2 mRNA-binding protein (Imp2) known be upregulated in many cancers regulate signaling activity insulin-like (IGF2). However, relatively little about its role...
To develop a clinic-relevant protocol for systemic up-regulation of NFE2-related factor 2 (Nrf2) to prevent diabetic cardiomyopathy (DCM), male db/db and age-matched wild-type (WT) mice were given sulforaphane (SFN, an Nrf2 activator) its natural source, broccoli sprout extract (BSE) by gavage every other day 3 months, with four groups: vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high 1.0 (0.5 mg/kg). Cardiac function pathological changes (hypertrophy,...
The prognostic value of SMAD4 in pancreatic cancer has been evaluated several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate association between expression and outcome patients by performing a meta-analysis.We systematically searched for relevant studies evaluating relationship until May 2015. A meta-analysis was performed using STATA 12.0, pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used estimate strength prognosis...
Abstract Introduction Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced dysfunction with prognosis remains obscure. Materials and methods All 154 patients COVID-19 were recruited from Second People’s Hospital Fuyang City in Anhui, China. Demographic characteristics laboratory data extracted. Renal was evaluated its followed up based on a...
Abstract Obesity often leads to obesity‐related cardiac hypertrophy ( ORCH ), which is suppressed by zinc‐induced inactivation of p38 mitogen‐activated protein kinase (p38 MAPK ). In this study, we investigated the mechanisms zinc inactivates prevent . Mice (4‐week old) were fed either high fat diet HFD , 60% kcal fat) or normal ND 10% containing variable amounts (deficiency, and supplement) for 3 6 months. P38 si RNA inhibitor SB 203580 used suppress activity in vitro vivo respectively....
Background: Many studies have identified the important role of 8-isoprostane (8-iso-PGF2α) in pulmonary diseases. However, 8-iso-PGF2α community-acquired pneumonia (CAP) remains unclear. Therefore, main goal was to investigate correlations serum with severity and prognosis CAP patients through a hospital-based retrospective cohort study. Methods: All 220 were enrolled. Demographic information clinical data collected. Levels inflammatory cytokines detected using ELISA. Results: The levels...
Collagen triple helix repeat containing 1 (CTHRC1), an extracellular matrix-related protein, has been found to be upregulated in many solid tumors and contributes tumorigenesis. We that CTHRC1 is overexpressed glioblastoma tissues cells. By using the technique of RNA interference, expression human U-87MG cell line was downregulated, proliferation migration cells were examined. The results showed knockdown exerts inhibitory effects on ability Knockdown resulted upregulation E-cadherin...
Abstract Background Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 community-acquired pneumonia (CAP) remains unknown. This study aims to examine correlations between serum with severity and prognosis CAP patients through a prospective cohort study. Methods All 239 were recruited. Serum was detected by enzyme-linked immunosorbent assay (ELISA). The evaluated scores, including CURB-65, CRB-65, PSI,...
Both diabetes and angiotensin II (Ang II) excess trigger cardiac remodeling dysfunction, diabetic cardiomyopathy. We hypothesized that hypertrophy associated with the development of cardiomyopathy is worsened by increased Ang II. Male type 1 OVE26 wild-type mice were given (sc., 1.15 mg/kg, twice a day) for 14 days. Diabetes-induced dysfunction was exacerbated treatment as determined echocardiography, wheat germ agglutinin staining atrial natriuretic peptide. dramatically diabetes-caused...
Previous studies have demonstrated that 8-hydroxydeoxyguanosine (8-OHdG) exerted key roles in various pulmonary diseases, but the evidence for its role community-acquired pneumonia (CAP) was lacking. The goal of this research to evaluate correlations serum 8-OHdG with severity and prognosis among patients CAP through a prospective cohort study. A total 239 healthy participants were enrolled. Fasting blood samples collected. inflammatory cytokines measured by ELISA. On admission,...
Abstract Background Ovarian cancer greatly threatens the general health of women worldwide. Implementation predictive prognostic biomarkers aids in ovarian management. Methods Using online databases, expression profile, target-disease associations, and interaction network PAWR were explored. To identify role cancer, gene correlation analysis, survival combined analysis drug responsiveness performed. The value was further validated clinical samples. Results widely expressed normal tissues,...
Abstract Introduction: Increasing evidence indicate that coronavirus disease 2019 (COVID-19) is companied by renal dysfunction. However, the association of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)-induced dysfunction with prognosis remains unclear. Materials and methods: This prospective case-cohort study analyzed 154 COVID-19 patients from Second People’s Hospital Fuyang City in Anhui Province. Clinical demographic information were collected. Renal function was evaluated...
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