A5052796762- Animal Nutrition and Physiology
- Aquaculture disease management and microbiota
- Neural dynamics and brain function
- Advanced biosensing and bioanalysis techniques
- Soil erosion and sediment transport
- RNA Interference and Gene Delivery
- Muscle Physiology and Disorders
- Coastal wetland ecosystem dynamics
- MicroRNA in disease regulation
- Visual perception and processing mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Wheat and Barley Genetics and Pathology
- Soil Carbon and Nitrogen Dynamics
- Liver Disease Diagnosis and Treatment
- Proteins in Food Systems
- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- RNA Research and Splicing
- Animal Genetics and Reproduction
- Coastal and Marine Dynamics
- Plant Stress Responses and Tolerance
- Genetic and phenotypic traits in livestock
- Urban Heat Island Mitigation
- Hydrology and Drought Analysis
- Cell Adhesion Molecules Research
First Hospital of Jilin University
2016-2025
Jilin University
2012-2025
National University of Singapore
2025
Tibet University
2025
Zhejiang University of Science and Technology
2024
Xuzhou Medical College
2023-2024
Southwestern University of Finance and Economics
2022-2024
Beijing Forestry University
2023-2024
Ministry of Housing and Urban-Rural Development
2023
Wuhan University
2022-2023
Rolling circle amplification (RCA) enables the facile construction of compact and versatile DNA nanoassemblies which are yet rarely explored for intracellular analysis. This is might be ascribed to uncontrollable inefficient probe integration/activation. Herein, by encoding with tandem allosteric deoxyribozyme (DNA-cleaving DNAzyme), a multifunctional RCA nanogel was established realizing efficient microRNA imaging via successive activation RCA-disassembly module signal module. The...
Obesity is a top public health concern, and molecule that safely treats obesity urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties helps protect against certain types of cancer. Here, we show in mice disulfiram prevented body weight gain abrogated the adverse impact obesogenic diet on insulin responsiveness while mitigating liver steatosis pancreatic islet hypertrophy. Additionally,...
Accurate diagnosis requires the development of multiple-guaranteed DNA circuits. Nevertheless, for reliable multiplexed molecular imaging, existing circuits are limited by poor cell-delivering homogeneity due to their cumbersome and dispersive reactants. Herein, we developed a compact-yet-efficient hierarchical hybridization (HDH) circuit in situ simultaneous analysis multiple miRNAs, which could be further exploited specifically discriminating cancer cells from normal ones. By integrating...
Abstract Hong Kong is one of the most high‐rise and highly compact cities in world. The urban land surface heterogeneous, which creates low‐level convergence zones areas, particularly Kowloon Peninsula. zone due to combined effect heat island circulation (UHIC) sea‐land breeze (SLBC) under weak northeasterly synoptic flow. To study impacts anthropogenic fluxes built‐up areas on local circulation, Weather Research Forecasting (WRF) mesoscale model with multilayer canopy building...
Abstract Numerical modeling efforts in support of restoration and protection activities coastal Louisiana have traditionally been conducted externally to any stakeholder engagement processes. This separation has resulted planning- project-level models built solely on technical observation analysis natural Despite its scientific rigor, this process often fails account for the knowledge, values, experiences local stakeholders that contextualizes a modeled system. To bridge gap, team social...
Abstract. Soil erosion, considered a major environmental and social problem, leads to the loss of soil nutrients degradation structure impacts plant growth. However, data on effects land use changes caused by vegetation restoration erodibility for different slope aspects are limited. This study was conducted detect response aspect in typical watershed northern agro-pastoral ecotone China. The following indexes were used determine improvement through weighted summation method: comprehensive...
Thalamic neurons respond to visual scenes by generating synchronous spike trains on the timescale of 10–20 ms that are very effective at driving cortical targets. Here we demonstrate this activity contains unexpectedly rich information about fundamental properties stimuli. We report occurrence firing cat thalamic cells with highly overlapping receptive fields is strongly sensitive orientation and direction motion stimulus. show stimulus selectivity robust, remaining relatively unchanged...
Abstract Background Birds have various plumage color patterns, and spot is a common phenotype. Herein, we conducted genome-wide association studies (GWAS) in population of 225 ducks with different sized black spots to reveal the genetic basis this phenomenon. Results First, quantified phenotype within duck population. The results showed that uncolored area body surface first appeared on ventral side. With increasing age, was highly conserved across whole surface. GWAS identified 198 kb...
Open AccessCCS ChemistryRESEARCH ARTICLES6 Oct 2022Construction of a Stimuli-Responsive DNAzyme-Braked DNA Nanomachine for the Amplified Imaging miRNAs in Living Cells and Mice Yingying Chen†, Mingzhu Yan†, Yushi Wang, Jinhua Shang, Shizhen He, Yuhui Gao, Chen Hong, Xiaoqing Liu Fuan Wang Chen† College Chemistry Molecular Sciences, Wuhan University, 430072 , Yan† Shang He Gao Hong *Corresponding authors: E-mail Address: [email protected] https://doi.org/10.31635/ccschem.022.202202171...
Tuberculosis is a main cause of pericardial disease in developing countries. However, patients with atypical clinical presentation, it can lead to misdiagnosis, missed diagnosis, and delayed treatment. In this study, we report case 61-year-old woman admitted the cardiac intensive care unit "weakness loss appetite" large effusion shown by echocardiography. After hospitalization, pericardiocentesis was performed, fluid hemorrhagic. Xpert MTB/RIF T-SPOT tests were negative, repeated phlegm...
Flash drought recovery is significant to evaluate the impact of flash and resilience ecosystem. However, definition stage its mechanism remain unclear, with limited research in this area. This study proposes definitions based on soil moisture change gross primary productivity (GPP) change. The spatio-temporal characteristics, driving factors differences between two identifications are investigated Xiang River Basin (XRB) Wei (WRB), typical humid semiarid basins China. main results as...
Cuproptosis, a new cell death pattern, is promising as an intervention target to treat tumors. Abnormal long non-coding RNA (lncRNA) expression closely associated with the occurrence and development of papillary renal carcinoma (pRCC). However, cuproptosis-related lncRNAs (CRLs) remain largely unknown prognostic markers for pRCC. We aimed forecast prognosis pRCC patients by constructing models according CRLs examine correlation between signatures inflammatory microenvironment. From Cancer...
Insulin resistance (IR) reduces insulin efficacy and heightens the danger of cardiovascular diseases including hypertension. The Metabolic Score for Resistance (METS-IR), which is based on triglyceride (TG) high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), fasting glucose levels, provides a simpler way to assess IR. As hypertension's prevalence increases, particularly in those with metabolic disorders, exploring relationship between hypertension METS-IR has become crucial....
3-Ketosteroid-Δ1-dehydrogenase (KstD) is a key enzyme in the metabolic pathway for chemical modifications of steroid hormones. Only few KstDs have thus far been characterized biochemically and applied production steroidal pharmaceutical intermediates. Three KstDs, KstD1, KstD2, KstD3, were identified Mycobacterium neoaurum DSM 1381, they shared up to 99, 85 97% amino acid identity with previously reported respectively. In this paper, from M. 1381 investigated exemplified their potential...
The effects of exogenous salicylic acid (SA), sodium nitropusside (SNP, a nitric oxide donor), or their combination on dwarf polish wheat (Triticum polonicum L.) seedlings under UV-B stress were studied. significantly decreased plant height, shoot dry mass, pigment content, net photosynthetic rate, intercellular CO2 concentration, stomatal conductance, transpiration and variable to maximum chlorophyll fluorescence ratio (Fv/Fm) in all plants, but less the presence SA, SNP, combination. On...