A5075013089- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Dietary Effects on Health
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Sirtuins and Resveratrol in Medicine
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Cancer-related cognitive impairment studies
Colorado State University
2020-2025
The University of Sydney
2016-2021
Anzac Research Institute
2016-2020
National Institute on Aging
2015-2020
National Institutes of Health
2020
Collins College
2020
Harry Perkins Institute of Medical Research
2019
Concord Repatriation General Hospital
2016-2018
Dementia Australia
2018
Colorado College
2014
Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for health. We compared hippocampus biology memory mice subjected to 20% CR or provided ad access one of three LPHC a control diet. Patterns RNA expression the 15-month-old were similar between fed when we looked at genes associated with longevity, cytokines, dendrite morphogenesis....
Obesity is a top public health concern, and molecule that safely treats obesity urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties helps protect against certain types of cancer. Here, we show in mice disulfiram prevented body weight gain abrogated the adverse impact obesogenic diet on insulin responsiveness while mitigating liver steatosis pancreatic islet hypertrophy. Additionally,...
Abstract Transcriptomic markers of aging can be useful for studying age‐related processes and diseases. However, noncoding repetitive element (RE) transcripts, which may play an important role in aging, are commonly overlooked transcriptome studies—and their potential as a transcriptomic marker has not been evaluated. Here, we used multiple RNA‐seq datasets generated from human samples Caenorhabditis elegans found that most RE transcripts (a) accumulate progressively with aging; (b) to...
Recent research has shown significant health benefits deriving from high-dietary fiber or microbiome-accessible carbohydrate consumption. Compared with native starch (NS), dietary resistant (RS) is a high that significantly alters the gut microbiome. The aim of this study was to determine systemic metabolic effects carbohydrate. Male C57BL/6 mice were divided into 2 groups and fed either NS RS for 18 wk (n = 20/group). Metabolomic analyses revealed plasma levels numerous metabolites...
Abstract Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key disease), but their upstream causes are incompletely understood. Age‐related increases in transposable element (TE) transcripts might function with aging, as reverse transcriptase inhibitor 3TC reduces inflammation...
Abstract Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver both age- tau-associated neuroinflammation NF-κB NLRP3 signaling axis. However, current treatments targeting or may have adverse/systemic effects, most not been clinically translatable. In this study, we tested efficacy a novel, nucleic acid therapeutic (Nanoligomer)...
Aging | doi:10.18632/aging.100942. Michel Bernier, Devin Wahl, Ahmed Ali, Joanne Allard, Shakeela Faulkner, Artur Wnorowski, Mitesh Sanghvi, Ruin Moaddel, Irene Alfaras, Julie A. Mattison, Stefano Tarantini, Zsuzsanna Tucsek, Zoltan Ungvari, Anna Csiszar, Kevin J. Pearson, Rafael de Cabo
Although the basic morphological characteristics of neurons in cerebellar cortex have been documented several species, virtually nothing is known about quantitative these across different taxa. To that end, present study investigated neuronal morphology among eight different, large-brained mammalian species comprising a broad phylogenetic range: afrotherians (African elephant, Florida manatee), carnivores (Siberian tiger, clouded leopard), cetartiodactyls (humpback whale, giraffe) and...
ABSTRACT Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer’s disease, which is characterized by the aggregation of pathological tau. One major driver both age- tau-associated neuroinflammation NF-κB NLRP3 signaling axis. However, current treatments targeting or may have adverse/systemic effects, most not been clinically translatable. In this study, we tested efficacy a novel, nucleic acid therapeutic (Nanoligomer)...
Abstract Transcripts from noncoding repetitive elements (REs) in the genome may be involved aging. However, they are often ignored transcriptome studies on healthspan and lifespan, their role healthy aging interventions has not been characterized. Here, we analyze REs RNA-seq datasets mice subjected to robust healthspan- lifespan-increasing including calorie restriction, rapamycin, acarbose, 17-α-estradiol, Protandim. We also examine RE transcripts long-lived transgenic mice, a high-fat...
Aging is the primary risk factor for development of many chronic diseases, including dementia, cardiovascular disease, and diabetes. There significant interest in identifying novel “geroprotective” agents, by repurposing existing drugs, but such treatments may affect organ systems differently. One current example nucleoside reverse transcriptase inhibitor 3TC, which has been increasingly studied as a potential gerotherapeutic. Recent data suggest 3TC reduce inflammation improve cognitive...
This review synthesizes the emerging understanding of roles glial cells and non-coding RNAs (ncRNAs) in pathogenesis progression Alzheimer’s disease related dementias (ADRDs). ADRDs encompass a spectrum neurodegenerative disorders characterized by cognitive decline, memory impairment, functional deterioration. The interplay between most common types cells—astrocytes, microglia, oligodendrocytes—and ncRNAs is as critical factor development ADRDs. Glial are essential for maintaining...
Macronutrients and dietary energy influence aging, age-related health, life span. Reduction in telomere length has been proposed as one mechanism for aging. Therefore, this study investigated the effects of varying ratios macronutrients on older adult mice. C57Bl/6 mice were fed ad libitum their entire 25 diets protein, carbohydrates, fat, energy. Average ratio (ATLR) was measured by polymerase chain reaction livers a subset 161 aged 15 months. There significant positive relationship between...