A5034881251- Space Satellite Systems and Control
- Space exploration and regulation
- Astro and Planetary Science
- Planetary Science and Exploration
- Spacecraft Design and Technology
- Space Exploration and Technology
- Space Science and Extraterrestrial Life
- High-Velocity Impact and Material Behavior
- Rocket and propulsion systems research
- Ionosphere and magnetosphere dynamics
- Nuclear Issues and Defense
- Amyotrophic Lateral Sclerosis Research
- Lysosomal Storage Disorders Research
- Cerebral Palsy and Movement Disorders
- Neonatal and fetal brain pathology
- Cellular transport and secretion
- GNSS positioning and interference
- Autoimmune and Inflammatory Disorders Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Wound Healing and Treatments
- Laser-induced spectroscopy and plasma
- Spacecraft Dynamics and Control
- Aerospace Engineering and Control Systems
National Institute on Aging
2023-2025
Institute on Aging
2023-2025
Data Tecnica International (United States)
2023-2024
National Institute of Neurological Disorders and Stroke
2018-2024
National Institutes of Health
2021-2024
University of Massachusetts Boston
2024
National Institute on Alcohol Abuse and Alcoholism
2024
University of Alabama at Birmingham
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2023
Animal and Plant Health Agency
2023
iCn3D was initially developed as a web-based 3D molecular viewer. It then evolved from visualization into full-featured interactive structural analysis software. became collaborative research instrument through the sharing of permanent, shortened URLs that encapsulate not only annotated visual scenes, but also all underlying data and scripts in FAIR manner. More recently, with growth databases, need to analyze large datasets systematically led us use Python convert code be used Node. js...
To acquire an unbiased technical assessment of (1) the research needed to better understand debris environment, (2) necessity and means protecting spacecraft against (3) potential methods reducing future hazard, NASA asked National Research Council form international committee examine orbital issue. The was draw upon available data analyses to: characterize current project how this environment might change in absence new measures alleviate proliferation, ongoing alleviation activities,...
Although the basic morphological characteristics of neurons in cerebellar cortex have been documented several species, virtually nothing is known about quantitative these across different taxa. To that end, present study investigated neuronal morphology among eight different, large-brained mammalian species comprising a broad phylogenetic range: afrotherians (African elephant, Florida manatee), carnivores (Siberian tiger, clouded leopard), cetartiodactyls (humpback whale, giraffe) and...
Niemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive, lethal, lysosomal disease characterized by progressive cerebellar ataxia and cognitive impairment. Although the NPC1 phenotype heterogeneous with variable age of onset, classical a pediatric disorder. Currently there are no therapies approved FDA therapeutics trials for complicated rarity, heterogeneity, relatively slow rate neurological decline. Thus, identification relevant biomarkers necessary to provide tools that can...
ABSTRACT BACKGROUND With recent findings connecting Epstein-Barr virus to increased risk of multiple sclerosis and growing concerns regarding the potential neurological impact coronavirus pandemic, we surveyed biobank scale real-world data identify links between viral exposures neurodegenerative disease risks. METHODS To assess diseases due exposures, mined time series from FinnGen as a discovery dataset cross-sectional UK Biobank replication for 73 pairs common outcomes. We investigated...
Abstract INTRODUCTION Variants of uncertain significance (VUS) surged with affordable genetic testing, posing challenges for determining pathogenicity. We examine the pathogenicity a novel VUS P93S in Annexin A11 (ANXA11) – an amyotrophic lateral sclerosis/frontotemporal dementia‐associated gene corticobasal syndrome kindred. Established ANXA11 mutations cause aggregation, altered lysosomal‐RNA granule co‐trafficking, and transactive response DNA binding protein 43 kDa (TDP‐43)...
TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate in neurons are not well understood. We generated Halo-TDP-43 knock-in iPSC line performed genome-wide CRISPR interference FACS-based screen to identify modifiers levels neurons. A meta-analysis our publicly available screens identified both specific hits present multiple screens, latter likely responsible for generic protein level maintenance. BORC, complex required...
TDP-43 mislocalization and pathology occurs across a range of neurodegenerative diseases, but the pathways that modulate in neurons are not well understood. We generated Halo-TDP-43 knock-in iPSC line performed genome-wide CRISPR interference FACS-based screen to identify modifiers levels neurons. A meta-analysis our publicly available screens identified both specific hits present multiple screens, latter likely responsible for generic protein level maintenance. BORC, complex required...
The rare, fatal neurodegenerative disorder Niemann-Pick disease type C1 (NPC1) arises from lysosomal accumulation of unesterified cholesterol and glycosphingolipids. These subcellular pathologies lead to phenotypes hepatosplenomegaly, neurological degeneration premature death. timing severity NPC1 clinical presentation is extremely heterogeneous. This study analyzed RNA-Seq data 42 patient-derived, primary fibroblast cell lines determine transcriptional changes induced by treatment with...