A5103242495- Genetic Associations and Epidemiology
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Genetic diversity and population structure
- Avian ecology and behavior
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Translation Studies and Practices
- Caveolin-1 and cellular processes
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diabetes Management and Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Catalytic Processes in Materials Science
- Genomics and Phylogenetic Studies
- Seed and Plant Biochemistry
- Signaling Pathways in Disease
- Ultrasound and Hyperthermia Applications
Wellcome Sanger Institute
2020-2025
Huazhong University of Science and Technology
2007-2025
Chengdu University of Traditional Chinese Medicine
2022-2025
Sun Yat-sen University
2010-2025
Lanzhou University
2025
Nanchang University
2019-2025
State Ethnic Affairs Commission
2024-2025
National Clinical Research Center for Digestive Diseases
2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Chongqing Medical University
2014-2024
The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire development translational gene therapy vectors for targeting neurological diseases in humans, we sought elucidate host factors responsible CNS tropism vectors. Leveraging differences 13 strains, systematically determined a set genetic variants that segregate with permissivity phenotype, rapidly...
Viruses have evolved the ability to bind and enter cells through interactions with a wide variety of cell macromolecules. We engineered peptide-modified adeno-associated virus (AAV) capsids that transduce brain introduction de novo 2 proteins expressed on mouse blood–brain barrier (BBB), LY6A or LY6C1. The in vivo tropisms these are predictable as they dependent cell- strain-specific expression their target protein. This approach generated hundreds dramatically enhanced central nervous...
Polygenic risk scores (PRSs) are an emerging tool to predict the clinical phenotypes and outcomes of individuals. We propose PRSmix, a framework that leverages PRS corpus target trait improve prediction accuracy, PRSmix+, which incorporates genetically correlated traits better capture human genetic architecture for 47 32 diseases/traits in European South Asian ancestries, respectively. PRSmix demonstrated mean accuracy improvement 1.20-fold (95% confidence interval [CI], [1.10; 1.3]; p = 9.17 × 10
Caffeic acid phenethyl ester (CAPE) could ameliorate myocardial ischemia/reperfusion injury (MIRI) by various mechanisms, but there hadn't been any reports on that CAPE regulate silent information regulator 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) to exert cardioprotective effect. The present study aimed investigate the potential of caffeic o-nitro (CAPE-oNO2) MIRI possible mechanism based positive control CAPE. SD rats were subjected left coronary artery ischemia /reperfusion...
Ulcerative colitis (UC) is a chronic inflammatory disease. Patients with UC typically exhibit disruption of the Treg/Th17 immune axis, but its exact mechanism still unclear. This study first analyzed RNA- seq data from public databases humans and mice, in vitro cytology experiments were conducted to induce or inhibit expression SIRT1. In vivo, mice treated moxibustion SIRT1 inhibitor EX-527 confirm changes transcription factors identified through analysis datasets. The results show that axis...
<ns3:p>Objective To estimate the prevalence of organophosphate (OP) poisoning in Nepal. Methods PubMed, Web Science Core Collection (WoSCC), Cochrane Library, Ovid, and Springer databases were searched. The search strategies used different until December 13, 2024. Joanna Briggs Institute (JBI) critical appraisal checklist was to assess quality included studies. R project pooled rate 95% confidence interval (<ns3:italic>CI</ns3:italic>) based on results heterogeneity test. Results Eleven...
The most abundant green tea polyphenol, epigallocatechin-3-gallate (EGCG), was found to induce differential effects between tumor cells and normal cells. Nevertheless, how epithelial respond the polyphenol at concentrations for which undergo apoptosis is undefined. current study tested exponentially growing aged primary human epidermal keratinocytes in response EGCG or a mixture of four major polyphenols. elicited cell differentiation with associated induction p57/KIP2 within 24 h...
Abstract Metastatic colonization is an ominous feature of cancer progression. Recent studies have established the importance pre-mRNA alternative splicing (AS) in biology. However, little known about transcriptome-wide landscape AS associated with metastatic colonization. Both vitro and vivo models were utilized to study regulation metastasis. Transcriptome profiling prostate cells derivatives crossing or barriers metastasis revealed factors significant gene expression changes These include...
Heat shock transcription factor (Hsfs) is widely found in eukaryotes and prokaryotes. Hsfs can not only help organisms resist high temperature, but also participate the regulation of plant growth development (such as involved seed maturity affects root length plants). The Hsf gene was first isolated from yeast then gradually plants sequenced, such Arabidopsis thaliana, rice, maize. Tartary buckwheat a rutin-rich crop, its nutritional value medicinal are receiving more attention. However,...
Abstract Background Previous studies have primarily implemented problem-based learning (PBL) or flipped classroom (FC) teaching models in different majors; however, research on the combined PBL-FC method clinical medicine is scarce. Therefore, we investigated ocular trauma students’ competencies. Method About 75 ophthalmology postgraduates were randomly divided into and traditional groups. Students completed pre-and post-class theoretical examinations, skills evaluation, ability scales,...
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of genome in runs homozygosity (FROH) common diseases Genes & Health (n = 23,978 British South Asians), UK Biobank 397,184), 23andMe. show that restricting analysis to offspring first cousins an effective way reducing confounding due social/environmental correlates FROH. Within this group G&H+UK Biobank, we found experiment-wide significant...