A5047553560- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Associations and Epidemiology
- ECG Monitoring and Analysis
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Atherosclerosis and Cardiovascular Diseases
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Function and Risk Factors
- Radiopharmaceutical Chemistry and Applications
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Medical Imaging Techniques and Applications
- Birth, Development, and Health
- Phonocardiography and Auscultation Techniques
- Neuroblastoma Research and Treatments
- Microbial metabolism and enzyme function
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
University of Turku
2016-2021
Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood. Detailed molecular profiles (87 metabolic measures 37 cytokines) were measured for up to 4260 women (24–49 years, 322 pregnant) from three population-based cohorts Finland. Circulating concentrations pregnant compared those non-pregnant women. Metabolic also reassessed 583 6 years later uncover the longitudinal changes response change...
Objective This study aimed to investigate the role of cytokines as intermediates in pathway from increased adiposity disease. Methods BMI and circulating levels up 41 were measured individuals three Finnish cohort studies ( n = 8,293). Mendelian randomization (MR) was used assess impact on BMI‐driven risk obesity‐related diseases. Results Observationally, associated with 19 cytokines. For every SD increase BMI, causal effect estimates strongest for hepatocyte growth factor, monocyte...
Circulating levels of growth factors involved in leucocyte production and angiogenesis could be indicative underlying aberrations tissue homeostasis therefore utilized as predictors risk for all-cause cardiovascular disease (CVD) or cancer mortality.Baseline plasma a range were measured two cohorts the population-based FINRISK study (1997 Discovery cohort, N = 8444, aged 25-74; 2002 Replication 2951, 51-74 years) using multiplexed bead array methodology ELISA. Participants followed up by...
Abstract Context: Metabolic inflammation contributes to the development of insulin resistance (IR), but roles different inflammatory and other cytokines in this process remain unclear. Objective: We aimed at analyzing value predicting future IR. Design, Setting, Participants: measured serum concentrations 48 from a nationwide cohort 2200 Finns (the Cardiovascular Risk Young Study), analyzed their role as independent risk factors for IR 4 years later. Main Outcome Measures: used...
Sialic acid–binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A <sup>68</sup>Ga-labeled peptide Siglec-9, <sup>68</sup>Ga-DOTA-Siglec-9, holds promise as novel PET tracer for imaging inflammation. This first-in-humans study investigated the safety, tolerability, biodistribution, and radiation dosimetry this radiopharmaceutical. <b>Methods:</b> Six healthy men underwent dynamic whole-body PET/CT. Serial venous blood samples were drawn from 1 to 240 min...
Abstract Introduction The motion sensors of a common smartphone when placed on chest can be used to detect vibrations caused by cardiac motion. concept has been shown atrial fibrillation (AFib) in clinical setting with 96% accuracy. Purpose We sought examine how the sensor based AFib detection performs various populations referred cardiology pooled from 3 different studies addressing arrhythmias, heart failure or suspected coronary artery disease. Methods From total 1 524 patient recordings...
Abstract Background Heart failure (HF) is the leading cause of hospitalization in people over age 65 years. More recently, cardiac motion sensor technology has emerged as a promising to detect HF. Methods In this multicenter study, we examined whether accelerometer and gyroscope signals from sensors collected using commercially available smartphones can classify HF status. Participants were enrolled Finland United States. hospitalized with acute decompensated assessed state re-assessed...
Abstract Background Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating inflammatory load, but exact mechanisms are incompletely understood. Methods To add understanding molecular inflammation, we performed genome-wide association study (GWAS) on 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) Northern Finland Birth Cohort 1966 (NFBC1966, N=5,284). A subsequent meta-analysis...
Introduction: The micro-electromechanical sensors of a common smartphone can be used to detect vibrations caused by cardiac motion when the is placed on chest. With commonly available CardioSignal application (App) concept has been shown atrial fibrillation (AFib) in clinical setting from 60 second recording. app certified CE IIa-class medical device and intended AFib adult population. heart failure (HF) frequently coexist together lead increased morbidity. To address this subgroup...