A5075166022- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Pluripotent Stem Cells Research
- DNA Repair Mechanisms
- Cardiac electrophysiology and arrhythmias
- RNA Interference and Gene Delivery
- FOXO transcription factor regulation
- Dietary Effects on Health
- Nutrition, Genetics, and Disease
- High Altitude and Hypoxia
- 3D Printing in Biomedical Research
- Health, Environment, Cognitive Aging
- Pancreatic function and diabetes
- Cardiovascular and exercise physiology
- Cancer, Hypoxia, and Metabolism
- ECG Monitoring and Analysis
- Heart Rate Variability and Autonomic Control
- Corrosion Behavior and Inhibition
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Interdisciplinary Research and Collaboration
- Redox biology and oxidative stress
- Telomeres, Telomerase, and Senescence
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
University of Copenhagen
2018-2025
National Institute on Aging
2016-2022
National Institutes of Health
2020-2022
University of Cincinnati
2005
Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, genetics. In this study, we conducted physiologic tests cross-sectionally throughout the entire lifespan male C57BL/6N mice. parallel, metabolomics analyses in serum, brain, liver, heart, skeletal muscle were also performed identify signatures frailty age-dependent...
Obesity is a top public health concern, and molecule that safely treats obesity urgently needed. Disulfiram (known commercially as Antabuse), an FDA-approved treatment for chronic alcohol addiction, exhibits anti-inflammatory properties helps protect against certain types of cancer. Here, we show in mice disulfiram prevented body weight gain abrogated the adverse impact obesogenic diet on insulin responsiveness while mitigating liver steatosis pancreatic islet hypertrophy. Additionally,...
Abstract ATP-citrate lyase is a central integrator of cellular metabolism in the interface protein, carbohydrate, and lipid metabolism. The physiological consequences as well molecular mechanisms orchestrating response to long-term pharmacologically induced Acly inhibition are unknown. We report here that inhibitor SB-204990 improves metabolic health physical strength wild-type mice when fed with high-fat diet, while healthy diet results imbalance moderated insulin resistance. By applying...
Abstract In the last two decades, great strides were made in our ability to extend life span of model organisms through dietary and other manipulations. Survival curves provide evidence altered aging processes but are uninformative on what lead that increase span. Longitudinal assessments health function during intervention studies could help identification predictive biomarkers for survival. Comparable healthspan necessary effectively translate interventions into human clinical trials. Gait...
Abstract Aging is influenced by a complex interplay of multifarious factors, including an individual’s genetics, environment, and lifestyle. Notably, high altitude may impact aging age-related diseases through exposures such as hypoxia ultraviolet (UV) radiation. To investigate this, we mined risk exposure data (summary value), disease burden (disability-adjusted life years (DALYs)), death rates expectancy from the Global Health Data Exchange (GHDx) National Management Center for Ethiopia...
Multiple interventions in the aging process have been discovered to extend healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target age-associated diseases. In this overview, we summarize presented talks discussion points 5th Annual Aging Drug Discovery Forum 2018 Basel, Switzerland. Here came together, discuss latest progress issues research. The meeting covered about mechanistic cause aging, how longevity signatures may...
Aging | doi:10.18632/aging.102487. Daniela Bakula, Andrea Ablasser, Adriano Aguzzi, Adam Antebi, Nir Barzilai, Martin-Immanuel Bittner, Martin Borch Jensen, Cornelis F. Calkhoven, Danica Chen, Aubrey D.N.J. de Grey, Jerome N. Feige, Anastasia Georgievskaya, Vadim Gladyshev, Tyler Golato, Andrei V. Gudkov, Thorsten Hoppe, Matt Kaeberlein, Pekka Katajisto, Brian K. Kennedy, Unmesh Lal, Ana Martin-Villalba, Alexey A. Moskalev, Ivan Ozerov, Michael Petr, Reason, David C. Rubinsztein, Alexander...
The combined influences of sinoatrial nodal (SAN) pacemaker cell automaticity and its response to autonomic input determine the heart's beating interval variability mean rate. To intrinsic SAN signatures buried within EKG RR time series change in advanced age, we measured before during double blockade at 3-month intervals from 6 months age until end life long-lived (those that achieved total cohort median span 24 beyond) C57/BL6 mice. Prior 21 time-dependent changes were relatively minor....
Amniotic epithelial cells (AECs) are a class of fetal stem that derives from the epiblast and resides in amnion until birth. AECs suitable candidates for regenerative medicine because ease collection, their low immunogenicity inability to form tumors after transplantation. Even though human have been widely investigated, fact remains very little is known about isolated rat, one most common animal models medical testing. In this study, we showed rat retained stemness properties plasticity,...
Abstract Transcriptome‐based drug screening is emerging as a powerful tool to identify geroprotective compounds intervene in age‐related disease. We hypothesized that, by mimicking the transcriptional signature of highly conserved longevity intervention FOXO3 ( daf ‐ 16 worms) overexpression, we could and repurpose with similar downstream effects increase longevity. Our silico screen, utilizing LINCS transcriptome database genetic compound interventions, identified several FDA‐approved that...
Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, field of research expanding alongside a growing focus from industry investors in research. This year's 8th Annual Research Drug Discovery (ARDD) meeting was organized as hybrid August 30th September 3rd 2021 with more than 130 attendees participating on-site at Ceremonial Hall University Copenhagen, Denmark, 1800 engaging online....
Abstract Transcriptome-based drug screening is emerging as a powerful tool to identify geroprotective compounds intervene in age-related disease. We hypothesized that, by mimicking the transcriptional signature of highly conserved longevity intervention FOXO3 ( daf-16 worms) overexpression, we could and repurpose with similar downstream effects increase longevity. Our silico screen, utilizing LINCS transcriptome database genetic compound interventions, identified several FDA-approved that...
Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands age- and mortality-associated features from text narratives call The Human Pathome (pathoage.com). Notably, can broadly determine when pathological starts, indicating a sexual dimorphism females earlier but slower males later faster. machine learning, employ unsupervised topic-modelling to identify terms themes predict age mortality. As...
Aging is influenced by a complex interplay of multifarious factors, including an individuals genetics, environment, and lifestyle. Notably, high altitude may impact aging age-related diseases through exposures such as hypoxia ultraviolet radiation. To investigate this, we mined summary exposure value measure risk levels, disability-adjusted life years (DALYs) disease burden from the Global Health Data Exchange (GHDx) for each subnational region Ethiopia, country with considerable differences...
SUMMARY There is currently no established intervention for Cockayne syndrome, a disease characterized by progressive early onset neurodegeneration with features of premature aging. Here, we tested if acetyl-CoA precursors, citrate and beta-hydroxybutyrate, could reduce syndrome in three model systems. We identified the gene Helicase 89B as homologue CSB drosophila found that ketone beta-hydroxybutyrate rescued aging Hel89B deficient flies. In mammals, loss carrier Indy exacerbated phenotype...
Abstract Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands age- and mortality-associated features from text narratives call The Human Pathome (pathoage.com). Notably, can determine when pathological starts at organism level, indicating a sexual dimorphism females earlier but slower males later faster. We employ unsupervised topic-modelling to identify terms themes predict age mortality....