A5066023144- Genetics, Aging, and Longevity in Model Organisms
- Ion channel regulation and function
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Circadian rhythm and melatonin
- Plant Stress Responses and Tolerance
- Gene Regulatory Network Analysis
- Antenna Design and Analysis
- Plant responses to elevated CO2
- Neuroscience and Neuropharmacology Research
- Wireless Communication Networks Research
- Soybean genetics and cultivation
- Millimeter-Wave Propagation and Modeling
- Light effects on plants
- Environmental and Agricultural Sciences
- Heat shock proteins research
- Crustacean biology and ecology
- Ion Transport and Channel Regulation
- Epigenetics and DNA Methylation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Chemical Synthesis and Analysis
- Health, Environment, Cognitive Aging
- Reproductive biology and impacts on aquatic species
- Ubiquitin and proteasome pathways
Chinese Academy of Sciences
2014-2025
Center for Excellence in Brain Science and Intelligence Technology
2016-2025
University of Chinese Academy of Sciences
2024
Shanghai Institutes for Biological Sciences
2002-2023
University of Wisconsin–Madison
2022-2023
Shanghai Institute of Applied Physics
2022
Shanghai Center for Brain Science and Brain-Inspired Technology
2020
Rutgers, The State University of New Jersey
2006-2009
Institute of Oceanology
2006
South China Sea Institute Of Oceanology
2006
Aging is accompanied with behavioral and cognitive decline. Changes in the neurotransmitter level are associated age-related deterioration, but whether well-known longevity manipulations affect function of system aging animals largely unclear. Here we report that serotonin (5-HT) dopamine (DA) decrease age C. elegans . The reduction results downregulation activity neurons controlled by 5-HT/DA signaling, deterioration some important behaviors, including pharyngeal pumping, food-induced...
Abstract Ion channels are important therapeutic targets, but the discovery of ion channel drugs remains challenging due to a lack assays that allow high-throughput screening in physiological context. Here we report C. elegans phenotype-based methods for drugs. Expression modified human ether-a-go-go-related gene (hERG) potassium results egg-laying and locomotive defects, which offer indicators small-molecule modulators. Screening worms expressing hERG A561V , carries trafficking-defective...
We have identified a family of ancillary subunits K(+) channels in Caenorhabditis elegans. MPS-1 and its related members MPS-2, MPS-3, MPS-4 are detected the nervous system nematode. Electrophysiological analysis ASE neurons mammalian cells epigenetic inactivation by double-stranded RNA interference (RNAi) vivo show that each MPS can associate with functionally endow voltage-gated channel KVS-1. In chemosensory neuron ADF, three different combine KVS-1 to form both binary (MPS-1.KVS-1)...
Imidacloprid, the most extensively utilized neonicotinoid insecticide in crop fields, is increasingly being detected drinking water sources, thereby posing significant risks to human health. Unfortunately, conventional methods for imidacloprid analysis water, such as liquid chromatography–tandem mass spectrometry (LC-MS/MS), are prohibitively expensive and time-consuming, rendering them unsuitable large-scale monitoring. The study described herein explores a surface-enhanced Raman...
Chloride channels (CLCs) transport anion across membrane to regulate ion homeostasis and acidification of intracellular organelles, are divided into anion/proton antiporters. Arabidopsis thaliana CLCa (AtCLCa) transporter localizes the tonoplast which imports NO3- a less extent Cl- from cytoplasm. The activity AtCLCa many other CLCs is regulated by nucleotides phospholipids, however, molecular mechanism remains unclear. Here we determine cryo-EM structures bound with Cl-, respectively. Both...
The human ether-a-go-go–related gene (hERG) encodes a voltage-gated potassium channel that controls repolarization of cardiac action potentials. Accumulating evidence suggests most disease-related hERG mutations reduce the function by disrupting protein biogenesis in endoplasmic reticulum (ER). However, molecular mechanism underlying ERG K+ channels is largely unknown. By forward genetic screening, we identified an ER-located chaperone CNX-1, worm homologue mammalian Calnexin, as critical...
N-type inactivation in voltage-gated K+ (Kv) channels is a widespread means to modulate neuronal excitability and signaling. Here we have shown novel mechanism of Caenorhabditis elegans Kv channel. The N-terminal sequence KVS-1 contains domain 22 amino acids that resembles the ball A-type channels, which preceded by eighteen acids. Wild type currents can be described as A-type; however, their kinetics are significantly (approximately 5-fold) slower. When putative deleted, current becomes...
Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, field of research expanding alongside a growing focus from industry investors in research. This year's 8th Annual Research Drug Discovery (ARDD) meeting was organized as hybrid August 30th September 3rd 2021 with more than 130 attendees participating on-site at Ceremonial Hall University Copenhagen, Denmark, 1800 engaging online....
Effects of 4 grade levels dietary α-tocopherol (37.82, 115.64, 349.42 and 522.56 mg kg−1 diet) on ovarian maturation reproductive performance broodstock shrimp, Litopenaeus vannamei were investigated. The concentrations in hepatopancreas, ovaries, eggs muscle female shrimp increased significantly as increased. Survival, spermatophore weight, sperm count, gonadosomatic index (GSI), hepatosomatic (HSI), fecundity egg diameter not affected by levels. Average daily spawns, hatching rate...
The human ether-a-go-go-related gene (hERG) K + channel conducts a rapidly activating delayed rectifier current (I Kr ), which is essential for normal electrical activity of the heart. Precise regulation hERG biogenesis critical serving its physiological functions, and deviations from result in diseases. However, mechanism underlying precise remains elusive. Here, by using forward genetic screen, we found that PATR-1, Caenorhabditis elegans homolog yeast DNA topoisomerase 2-associated...
Voltage-gated Kv4 channels control the excitability of neurons and cardiac myocytes by conducting rapidly activating-inactivating currents. The function is profoundly modulated K + channel interacting protein (KChIP) soluble auxiliary subunits. However, in vivo mechanism modulation not fully understood. Here, we identified three C. elegans KChIP-like (ceKChIP) proteins, NCS-4, NCS-5, NCS-7. All ceKChIPs alter electrical characteristics SHL-1, a ortholog, currents slowing down inactivation...
General anesthetics are widely used in the clinic and greatly promote development of surgery. However, incidence cardiovascular respiratory complications caused by general is still high, underlying mechanisms remain incompletely understood. Potassium channels expressed heart blood vessels participate regulating pressure, rate, other physiological parameters. Whether they directly affected intravenous unclear. Here, we independently express four classes potassium channels, TASK-1, TASK-3,...