A5041311211- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Electrospun Nanofibers in Biomedical Applications
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Photoreceptor and optogenetics research
- Metal complexes synthesis and properties
- Birth, Development, and Health
- Organometallic Compounds Synthesis and Characterization
- Epigenetics and DNA Methylation
- Amyotrophic Lateral Sclerosis Research
- Neuroscience and Neuropharmacology Research
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer, Hypoxia, and Metabolism
- Nerve injury and regeneration
- Circadian rhythm and melatonin
- Immune cells in cancer
Universidad de Sevilla
2018-2025
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2016-2025
Universidad Pablo de Olavide
2018-2025
Junta de Andalucía
2019-2024
Consejo Superior de Investigaciones Científicas
2023
Universitat de València
2007-2017
Johns Hopkins University
2011-2016
Johns Hopkins Medicine
2011-2015
University of Baltimore
2014-2015
Biomedical Research Networking Center on Neurodegenerative Diseases
2009-2015
Neurogenesis persists in the adult subventricular zone (SVZ) of mammalian brain. During aging, SVZ neurogenic capacity undergoes a progressive decline, which is attributed to decrease population neural stem cells (NSCs). However, behavior NSCs that remain aged brain not fully understood. Here we performed comparative ultrastructural study niche 2-month-old and 24-month-old male C57BL/6 mice, focusing on NSC population. Using thymidine-labeling, showed residual divide less frequently than...
Epidermal growth factor receptor (EGFR) signalling is a potent driver of glioblastoma, malignant and lethal form brain cancer. Disappointingly, inhibitors targeting tyrosine kinase activity are not clinically effective EGFR persists on the plasma membrane to maintain tumour invasiveness. Here we show that endolysosomal pH critical for sorting turnover. By functioning as leak pathway protons, Na+/H+ exchanger NHE9 limits luminal acidification circumvent turnover prolong downstream pathways...
Neural stem cells (NSCs) are regarded as a promising therapeutic approach to protecting and restoring damaged neurons in neurodegenerative diseases (NDs) such Parkinson's disease Alzheimer's (PD AD, respectively). However, new research suggests that NSC differentiation is required make this strategy effective. Several studies have demonstrated melatonin increases mature neuronal markers, which reflects into neurons. Nevertheless, the possible involvement of mitochondria effects during has...
Rationale: Glioblastoma (GBM) is the most fatal form of brain cancer and its treatment represents a persistent challenge. Mesenchymal stromal cells (MSCs) have been explored as therapeutic tools in management owing to their tumor-homing abilities. However, clinical application limited due controversial role MSCs carcinogenesis. This study investigates how influence tumor behavior explores synergistic anticancer effects combination with melatonin (Mel). Methods: Orthotopic subcutaneous GBM...
Diabetes is a chronic metabolic disorder that affects 415 million people worldwide. This pathology often associated with long-term complications, such as critical limb ischemia (CLI), which increases the risk of loss and mortality. Mesenchymal stromal cells (MSCs) represent promising option for treatment diabetes complications. Although MSCs are widely used in autologous cell-based therapy, their effects may be influenced by constant crosstalk between graft host, could affect MSC fate...
Cell therapy is a progressively growing field that rapidly moving from preclinical model development to clinical application. Outcomes obtained trials reveal the therapeutic potential of stem cell-based deal with unmet medical treatment needs for several disorders no options. Among adult cells, mesenchymal cells (MSCs) are leading cell type used in advanced therapies autoimmune, inflammatory and vascular diseases. To date, safety feasibility autologous MSC-based has been established;...
Radiotherapy is a highly effective tool for the treatment of brain cancer. However, radiation also causes detrimental effects in healthy tissue, leading to neurocognitive sequelae that compromise quality life cancer patients. Despite recognition this serious complication, no satisfactory solutions exist at present. Here we investigated intranasal administration human mesenchymal stem cell (hMSCs) as neuroprotective strategy cranial mice. Our results demonstrated intranasally delivered hMSCs...
The subventricular zone (SVZ) is the largest source of newly generated cells in adult mammalian brain. SVZ-derived neuroblasts migrate via rostral migratory stream (RMS) to olfactory bulb (OB), where they differentiate into mature neurons. Additionally, a small proportion contribute generation myelinating oligodendrocytes. production new SVZ decreases during aging, affecting incorporation neurons OB. However, age-related changes that occur across RMS are not fully understood. In this study...
Human induced pluripotent stem cells (iPSCs) provide a virtually inexhaustible source of starting material for next generation cell therapies, offering new opportunities regenerative medicine. Among different sources the iPSCs, urine are clinically relevant since these can be repeatedly obtained by non-invasive methods from patients any age and health condition. These attributes encourage to participate in preclinical clinical research. In particular, use urine-derived iPSC products is...
Abstract ATP-citrate lyase is a central integrator of cellular metabolism in the interface protein, carbohydrate, and lipid metabolism. The physiological consequences as well molecular mechanisms orchestrating response to long-term pharmacologically induced Acly inhibition are unknown. We report here that inhibitor SB-204990 improves metabolic health physical strength wild-type mice when fed with high-fat diet, while healthy diet results imbalance moderated insulin resistance. By applying...
The advent and growth of technological advances have led to new routes knowledge. Thereby, we currently face challenges. We just started get a glimpse the structural functional role neural stem cells in differentiation migration processes, origin synaptic networks, subsequent readjustments specific circuits. A whole range treatment possibilities originates from this knowledge that potentially can be used for different neurological diseases humans. Although is an encouraging scenario, it...
Radiation therapy is a part of the standard treatment for brain tumor patients, often resulting in irreversible neuropsychological deficits. These deficits may be due to permanent damage neural stem cell (NSC) niche, local progenitors, or neurotoxicity. Using computed tomography-guided localized radiation technique, we studied effects on NSC proliferation and neuroblast migration mouse brain. Localized irradiation subventricular zone (SVZ) eliminated proliferating precursor cells migrating...
Radiation is a common tool in the treatment of brain tumors that induces neurological deficits as side effect. Some these appear to be related impact radiation on neurogenic niches, producing drastic decrease proliferative capacity regions. In adult mammalian brain, subventricular zone (SVZ) lateral ventricles main niche. Neural stem/precursor cells (NSCs) within SVZ play an important role repair following injuries. However, irradiated NSCs' ability respond damage has not been previously...
Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this particular lineage, more effort is still required stress importance of developing an efficient, reproducible, easy, and cost-effective differentiation protocol obtain mature, homogeneous, functional insulin-secreting In addition, microRNAs (miRNAs) have emerged as a class small non-coding RNAs that regulate many cellular processes, including differentiation. Some miRNAs are...
The subventricular zone of the striatal wall adult rodents is an active neurogenic region for life. Cubic multiciliated ependyma separates from cerebrospinal fluid (CSF) and involved in control neurogenesis. By injecting neuraminidase Clostridium perfringens into right lateral ventricle rat, we provoked a partial detachment wall. contralateral was never affected used as experimental control. Neuraminidase caused widening intercellular spaces among some ependymal cells their subsequent...
Background Previous studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed postnatal ENU treatment induced lasting deficits proliferation of neural progenitors subventricular zone (SVZ), main neurogenic region adult mouse brain. The present study is aimed examine, mice exposed ENU, both structural features sites, incorporating...