A5031822961- Liver Disease and Transplantation
- Erythrocyte Function and Pathophysiology
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Mesenchymal stem cell research
- Peripheral Artery Disease Management
- Virus-based gene therapy research
- Electrospun Nanofibers in Biomedical Applications
- Heart Failure Treatment and Management
- interferon and immune responses
- Poisoning and overdose treatments
- Diabetic Foot Ulcer Assessment and Management
- Angiogenesis and VEGF in Cancer
- ECG Monitoring and Analysis
- Spectroscopy and Chemometric Analyses
- Endoplasmic Reticulum Stress and Disease
- Respiratory Support and Mechanisms
- COVID-19 diagnosis using AI
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Organ Transplantation Techniques and Outcomes
- Enhanced Recovery After Surgery
- Veterinary Pharmacology and Anesthesia
Hospital Universitario Fundación Jiménez Díaz
2003-2025
Universidad Autónoma de Madrid
2020-2025
Foundation University
2021
Hospital General Universitario de Alicante Doctor Balmis
2008-2014
Universitat de Miguel Hernández d'Elx
2008-2009
We tested the hypothesis that presence of bacterial DNA (bactDNA) in ascitic fluid and serum is associated with decreased survival patients cirrhosis. In a prospective, multicenter study, we analyzed clinical evolution 156 cirrhosis ascites (first or recurrence) lower than 250 polymorphonuclear cells (PMN)/muL, negative bacteriological culture, absence other infections being admitted for evaluation large-volume paracentesis, according to bactDNA at admission. Survival, causes death,...
Cell therapy is a progressively growing field that rapidly moving from preclinical model development to clinical application. Outcomes obtained trials reveal the therapeutic potential of stem cell-based deal with unmet medical treatment needs for several disorders no options. Among adult cells, mesenchymal cells (MSCs) are leading cell type used in advanced therapies autoimmune, inflammatory and vascular diseases. To date, safety feasibility autologous MSC-based has been established;...
The mainstay of treatment for acutely decompensated heart failure (ADHF) is intravenous diuretic therapy either as a bolus or via continuous infusion.We evaluated the clinical effects and safety three strategies furosemide administration used in emergency departments (EDs) ADHF.We performed multicentre, randomised, parallel-group study. Patients with ADHF were randomised within 2 h ED arrival to receive by infusion (10 mg/h, group 1) boluses (20 mg/6 h, 2; 20 mg/8 3). primary end point was...
Introduction unCoVer—Unravelling data for rapid evidence-based response to COVID-19—is a Horizon 2020-funded network of 29 partners from 18 countries capable collecting and using real-world (RWD) derived the provision care patients with COVID-19 by health systems across Europe elsewhere. unCoVer aims exploit full potential this information rapidly address clinical epidemiological research questions arising evolving pandemic. Methods analysis From onset pandemic, are gathering RWD electronic...
Eur J Clin Invest 2010; 41 (1): 8–15 Abstract Background Bacterial infections are common complications arising in patients with cirrhosis and ascites. Translocation of bacterial DNA is a dynamic process that associated an increased inflammatory response poor prognosis this setting. The aim study was to whether peritoneal macrophages remain chronic primed status allow rapid subsequent events translocation. Patients methods Peritoneal monocyte‐derived were isolated from 25 non‐infected ascites...
Alvaro Sánchez Barruecoa*, Fernando González Galána, Ignacio Alcalá Ruedaa, Jessica Mireya Santillán Coelloa, María Pilar Barrio Doradob, José Miguel Villacampa Aubáa, Manuel Escanciano Escancianoc, Lucía Llanos Jiménezd, Mahillo Fernándezd & Carlos Cenjor Españolaa ENT and Cervicofacial Surgery Department, Fundación Jiménez Diaz University Hospital, Madrid, Spainb Endocrinology Spainc Universidad Autónoma de Spaind Instituto Investigación Sanitaria, Research Unit, Spain
Drug-induced liver injury (DILI) profile in most drugs' available information is based on both the incidence of alanine aminotansferase (ALT) elevations clinical trials and published case reports.To assess relationship between ALT number reports postmarketing setting.Hepatotoxic drugs were identified from product labelling classified high-medium risk (Black Box Warning or Precautions section) low (a statement Adverse Reactions section). Incidence (> = 3 x ULN) for drug (I(D)) placebo (I(C))...
Use of non-steroidal anti-inflammatory drugs in cirrhosis has been associated with impairment renal function based on its ability to inhibit the production prostaglandins. Renal effects dipyrone patients have not evaluated. We aimed assess effect therapeutic doses used for short periods time cirrhosis. Twenty-nine were included an observer-blind clinical trial. Patients randomized receive three times a day oral acetaminophen (500 mg; N = 15) or (575 14) 72 hr. Serum and urine samples...
Abstract Rare variants affecting host defense against pathogens could be involved in COVID-19 severity and may help explain fatal outcomes young middle-aged patients. Our aim was to report the presence of rare genetic certain genes, by using whole exome sequencing, a selected group patients under 65 years who required intubation or resulting death (n = 44). To this end, different etiopathogenic mechanisms were explored gene prioritization-based analysis which genes immune response,...
Abstract Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted associate CHIP COVID-19 severity without conclusive findings. In the present work, we explore association between and mortality. Genomic DNA extracted from peripheral blood patients ( n = 241 deceased, 239 survivors) was sequenced Myeloid Solutions™ panel SOPHiA Genetics. The...
Abstract Background Chronic lower limb ischemia develops earlier and more frequently in patients with type 2 diabetes mellitus. Diabetes remains the main cause of lower-extremity non-traumatic amputations. Current medical treatment, based on antiplatelet therapy statins, has demonstrated deficient improvement disease. In recent years, research shown that it is possible to improve tissue perfusion through therapeutic angiogenesis. Both animal models humans, been cell can induce angiogenesis,...
Abstract Background/Aim The number of patients receiving amiodarone will increase in future years. As clinically significant hepatotoxicity associated with oral is infrequent and difficult to predict, a new Bayesian‐developed model proposed help the causality assessment amiodarone‐induced liver injury. Methods Incidence abnormal enzymes was obtained from placebo controlled clinical trials. Published case reports were identified through literature search. Maximum expected cases...
Background: Transthyretin cardiac amyloidosis (ATTR amyloidosis) is a frequent etiology of heart failure. Inflammation and mineral metabolism are associated with myocardial dysfunction clinical performance. Cardiac global longitudinal strain (GLS) allows function assessment prognosis. Our aim was to describe possible correlations between GLS, biomarker levels performance in ATTR amyloidosis. Methods: Thirteen patients were included. Clinical characteristics; echocardiographic features,...
Background: In susceptible hosts, SARS-CoV2 induced hyperinflammation accounts for an increased mortality. The search of adjuvant immunomodulatory therapies has been ongoing ever since the pandemic outbreak. Aim: Our purpose was to evaluate efficacy cyclosporin A (CsA) as add-on therapy standard care in patients with severe COVID-19 pneumonia. Methods: We conducted a randomized clinical trial admitted 8 Spanish Tertiary Hospitals. Patients were stratified into two severity categories and 1:1...
Background: In susceptible hosts, SARS-CoV2-induced hyperinflammation accounts for an increased mortality. The search of adjuvant immunomodulatory therapies has been ongoing ever since the pandemic outbreak. Aim: Our purpose was to evaluate efficacy cyclosporin A (CsA) as add-on therapy standard care (SoC) in patients with severe COVID-19 pneumonia. Methods: We conducted a randomized clinical trial admitted eight Spanish tertiary hospitals. Patients were stratified into two severity...
In March 2020, a protocol recommending the prescription of melatonin, among other sleep-and biorhythms-promoting measures, to hospitalized patients with coronavirus disease 2019 (COVID-19) sleep problems or delirium was sent from consultationliaison psychiatrist medical staff Fundaci on Jim enez D ıaz University Hospital (FJDUH) in Madrid, Spain.2][3][4] addition its circadian function, melatonin is thought have several health-promoting properties, including immune response modulation and...