A5046845141- HER2/EGFR in Cancer Research
- Cardiovascular Function and Risk Factors
- Proteoglycans and glycosaminoglycans research
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Glycosylation and Glycoproteins Research
- Wnt/β-catenin signaling in development and cancer
- Lymphatic System and Diseases
- Parathyroid Disorders and Treatments
- Breast Lesions and Carcinomas
- Peptidase Inhibition and Analysis
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Thyroid Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Protease and Inhibitor Mechanisms
- Reproductive Health and Contraception
- IgG4-Related and Inflammatory Diseases
- Pregnancy and Medication Impact
- Thyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Structural Anomalies and Repair
Hospital Universitario Fundación Jiménez Díaz
2000-2021
Universidad Autónoma de Madrid
1986-2006
As evidenced by scintigraphy imaging, the prevalence of transthyretin (TTR) cardiac amyloidosis in heart failure patients with preserved ejection fraction (HFpEF) and left ventricular hypertrophy (LVH) ranges between 13% 19%. The natural evolution begins deposition amyloid material myocardium, LVH ensuing at later stages. With current imaging modalities, it is possible to detect TTR before hypertrophic stage. aim this study was determine HFpEF without LVH.The prospectively enrolled admitted...
In order to study the association of histological grade (HG) with specific clinical and biological parameters which may influence behavior infiltrating ductal carcinomas breast (IDC), we analyzed in 229 tissue samples cytosolic concentrations estrogen receptor (ER), progesterone (PR), pS2, cathepsin D, hyaluronic acid (HA) tissue-type plasminogen activator (t-PA), as well those erbB2 oncoprotein, epidermal growth factor (EGFR), HA, CD44v5 CD44v6 cell membrane fraction. Likewise, considered...
Background: Transthyretin cardiac amyloidosis (ATTR amyloidosis) is a frequent etiology of heart failure. Inflammation and mineral metabolism are associated with myocardial dysfunction clinical performance. Cardiac global longitudinal strain (GLS) allows function assessment prognosis. Our aim was to describe possible correlations between GLS, biomarker levels performance in ATTR amyloidosis. Methods: Thirteen patients were included. Clinical characteristics; echocardiographic features,...
Heart failure (HF) with preserved ejection fraction (HFpEF) and monoclonal gammopathy of uncertain significance (MGUS) are two entities that share pathophysiological mechanisms. The aim herein, was to assess the prevalence MGUS in patients HFpEF no left ventricular (LV) hypertrophy, as well its association a pre-specified clinical endpoint at 12 months.The present study prospectively enrolled 69 admitted HF, ≥ 50%, LV wall thickness < mm. All were screened for MGUS. Clinical events...