A5015380251- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Redox biology and oxidative stress
- Mitochondrial Function and Pathology
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Biochemical Acid Research Studies
- Pancreatic function and diabetes
- Sulfur Compounds in Biology
- Metabolism, Diabetes, and Cancer
- Fibroblast Growth Factor Research
- Muscle metabolism and nutrition
- Birth, Development, and Health
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2020-2025
Universidad Pablo de Olavide
2020-2025
Universidad de Sevilla
2020-2025
Cleveland Clinic Lerner College of Medicine
2024
Junta de Andalucía
2020
Abstract ATP-citrate lyase is a central integrator of cellular metabolism in the interface protein, carbohydrate, and lipid metabolism. The physiological consequences as well molecular mechanisms orchestrating response to long-term pharmacologically induced Acly inhibition are unknown. We report here that inhibitor SB-204990 improves metabolic health physical strength wild-type mice when fed with high-fat diet, while healthy diet results imbalance moderated insulin resistance. By applying...
ATP citrate lyase (ACLY) inhibitors have the potential of modulating central processes in protein, carbohydrate, and lipid metabolism, which can relevant physiological consequences aging age-related diseases. Here, we show that hepatic phospho-active ACLY correlates with overweight Model for End-stage Liver Disease score humans. Wild-type mice treated chronically inhibitor potassium hydroxycitrate exhibited delayed early mortality. In AML12 hepatocyte cultures, hydroxycitrate, SB-204990,...