A5100421060- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Animal Disease Management and Epidemiology
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Adaptive Control of Nonlinear Systems
- Viral Infections and Outbreaks Research
- Mycobacterium research and diagnosis
- Cervical Cancer and HPV Research
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
Yangzhou University
2015-2025
Second Affiliated Hospital of Nanjing Medical University
2015-2025
Shandong First Medical University
2019-2025
Capital Medical University
2014-2025
Shanghai Jiao Tong University
2017-2025
Beijing Center for Disease Prevention and Control
2013-2025
First Affiliated Hospital of Xi'an Jiaotong University
2023-2025
Shanghai Children's Medical Center
2017-2025
North Minzu University
2023-2025
Taixing People's Hospital
2025
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, Mollusca. Here we report sequencing and assembly genome using short reads a fosmid-pooling strategy, along with transcriptomes development stress response proteome shell. is highly polymorphic rich in repetitive sequences, some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set genes responding environmental stress. expansion...
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and health
Abstract Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels soluble scavenger receptor-A (sSR-A) are increased patients with RA correlate positively clinical immunological features the disease. This discriminatory capacity sSR-A clinically valuable complements for early stage...
Background. Hemorrhagic fever–like illness caused by a novel Bunyavirus, Huaiyangshan virus (HYSV, also known as Severe Fever with Thrombocytopenia [SFTSV] and Fever, Leukopenia Syndrome [FTLS]), has recently been described in China. Methods. Patients laboratory-confirmed HYSV infection who were admitted to Union Hospital or Zhongnan between April 2010 October included this study. Clinical routine laboratory data collected blood, throat swab, urine, feces obtained when possible. Viral RNA...
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Long noncoding RNAs (lncRNAs) are thought to play a critical role in cancer development. Recently, lncRNA CASC9 was shown be dysregulated many types, but mechanisms whereby this occurs remain largely unknown. In study, we found that significantly upregulated ESCC tissues, with further analysis revealing elevated expression associated prognosis and metastasis. Furthermore, knockdown repressed migration...
Significance The SARS-CoV-2 spike protein is responsible for host receptor recognition, membrane fusion, and viral infection. Understanding the cellular inhibiting molecular mechanisms of spike-driven entry a research priority in curbing ongoing pandemic preventing future coronavirus outbreaks. Here, we highlight that generation S2′ fragments, proteolytic event occurring within S2 subunit, switch coupled to fusion. Downstream syncytia formation requires presence an cleavage site at arginine...
Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes, such cell growth and apoptosis. The SPRY4 intronic transcript 1 (SPRY4-IT1) is 708-bp lncRNA on chromosome 5 with potential functional role in tumorigenesis. clinical significance SPRY4-IT1 the effect cancer progression are unclear.Quantitative reverse transcriptase PCR (qRT-PCR) was performed to investigate expression 48 breast tissues four lines. Gain loss function approaches were...
Abstract Evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in the regulation of tumor cellular processes, such as proliferation, apoptosis, and metastasis. LncRNA CRNDE (Colorectal Neoplasia Differentially Expressed) is located at human chromosome 16 has been found overexpressed variety cancers including colorectal cancer (CRC). In this paper, we report lncRNA expression was remarkably upregulated CRC tissues overexpression positively correlated with advanced...
Abnormal expression of numerous long non-coding RNAs (lncRNAs) has been reported in esophageal squamous cell carcinoma (ESCC) recently, but the great majority their roles and mechanisms remain largely unclear. We aim to identify critical ESCC-associated lncRNAs elucidate functions detail. Microarrays were used analyze differentially expressed ESCC tissues. qRT-PCR was verify result microarrays. The effects most up-regulated lncRNA, cancer susceptibility candidate 9(CASC9), on growth,...
Recent advantages of serum microRNAs (miRNAs) open a new realm possibilities for noninvasive diagnosis and prognosis bladder cancer (BC). The aim our study was to identify miRNA expression signatures in patients with BC establish models the recurrence prediction. We performed genome-wide analysis by Miseq sequencing followed evaluations training validation sets reverse transcription quantitative real-time PCR assays from samples 250 240 controls. A six-miRNA panel (miR-152, miR-148b-3p,...
Abstract Background The high cost and insufficient supply of human papillomavirus (HPV) vaccines have slowed the pace controlling cervical cancer. A phase III clinical trial was conducted to evaluate efficacy, safety, immunogenicity a novel Escherichia coli-produced bivalent HPV-16/18 vaccine. Methods multicenter, randomized, double-blind started on November 22, 2012 in China. In total, 7372 eligible women aged 18–45 years were age-stratified randomly assigned receive three doses test or...
The aims of this study were to investigate the functions GAS5 as a tumor suppressor in cervical cancer and explore mechanism.The expression microRNA 21 (miR-21) was detected primary tissue specimens, well cell lines. We identified interaction miR-21 by quantitative polymerase chain reaction, Western blot, dual-luciferase reporter assay. also studied proliferation, apoptosis, migration, invasion cells vitro vivo. Finally, impact on cisplatin resistance its mechanism identified.The GAS5, which...
Abstract Exosomes are small membrane vesicles released by many cells. These can mediate cellular communications transmitting active molecules including long non‐coding RNA s (lnc RNAs ). In this study, our aim was to identify a panel of lnc in serum exosomes for the diagnosis and recurrence prediction bladder cancer ( BC The expressions 11 candidate exosome were investigated training set (n = 200) an independent validation 320) via quantitative real‐time PCR . A three‐lnc PCAT ‐1, UBC 1 SNHG...
H7N9 virus has caused five infection waves since it emerged in 2013. The highest number of human cases was seen wave 5; however, the underlying reasons have not been thoroughly elucidated. In this study, geographical distribution, phylogeny, and genetic evolution 240 viruses 5, including 35 new isolates from patients poultry nine provinces, were comprehensively analyzed together with strains first four waves. Geographical distribution analysis indicated that newly emerging highly pathogenic...
Bone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival quality life. Osteolytic BoM characterised by aberrant differentiation malfunction osteoclasts through modulation the TGF-β/pTHrP/RANKL signalling pathway, but its upstream regulatory mechanism unclear. In this study, we found that lncRNA-SOX2OT was highly accumulated in exosomes derived from peripheral blood NSCLC patients with higher...
Pulmonary infection is a heterogeneous and complex infectious disease with high morbidity mortality worldwide. In clinical practice, considerable proportion of the etiology pulmonary unclear, microbiological diagnosis being challenging. Metagenomic next-generation sequencing detects all nucleic acids in sample an unbiased manner, revealing microbial community environment organisms improving detection diseases settings.