A5003315105- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Pharmacological Effects of Natural Compounds
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Hepatitis C virus research
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Immune responses and vaccinations
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Acute Ischemic Stroke Management
- Andrographolide Research and Applications
- Virus-based gene therapy research
- COVID-19 Impact on Reproduction
- Botulinum Toxin and Related Neurological Disorders
- Bacillus and Francisella bacterial research
- Traditional Chinese Medicine Studies
- Osteoarthritis Treatment and Mechanisms
- interferon and immune responses
Institute of Infection and Immunity
2024-2025
University of Chinese Academy of Sciences
2021-2025
Shanghai Blood Center
2024
Soochow University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
Guangzhou Medical University
2024
Institut Pasteur of Shanghai
2021-2024
Response Biomedical (Canada)
2024
Naval University of Engineering
2024
Significance The SARS-CoV-2 spike protein is responsible for host receptor recognition, membrane fusion, and viral infection. Understanding the cellular inhibiting molecular mechanisms of spike-driven entry a research priority in curbing ongoing pandemic preventing future coronavirus outbreaks. Here, we highlight that generation S2′ fragments, proteolytic event occurring within S2 subunit, switch coupled to fusion. Downstream syncytia formation requires presence an cleavage site at arginine...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptidyl-dipeptidase A) (ACE2) is the primary receptor for SARS-CoV-2 entry into host cells, and studies have shown presence intracellular virus particles human hepatocytes that express ACE2, but at extremely low levels. Consequently, we asked if might receptors other than ACE2...
Innate immune responses triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play pivotal roles in the pathogenesis of COVID-19, while host factors including pro-inflammatory cytokines are critical for viral containment. By utilizing quantitative and qualitative models, we discovered that soluble secreted human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion viral-infected cells. Through cytokine screening, identified interleukin-1β (IL-1β), a...
Innate immune responses triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play pivotal roles in the pathogenesis of COVID-19, while host factors including proinflammatory cytokines are critical for viral containment. By utilizing quantitative and qualitative models, we discovered that soluble secreted human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion viral-infected cells. Through cytokine screening, identified interleukin-1β (IL-1β), a key...
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly mutations present challenges to current therapeutics. spike glycoprotein is not only essential for initial viral entry, but also responsible transmission components via syncytia formation. Spike-mediated cell-cell strongly resistant extracellular therapeutic convalescent antibodies an unknown mechanism. Here, we describe antibody-mediated activation formation on...
Seroprevalence of Toxoplasma gondii infection in fattening pigs Heilongjiang Province, northeast China, was investigated between July 2011 and June 2012. In total, 1,014 pig serum samples were collected from 10 administrative regions assayed for T. antibodies by indirect hemagglutination (IHA) test using a commercially available kit. The average antibody-positive prevalence 4.6% (47/1,014), which is relatively lower than that other provinces China. raised on small farms (6.3%) significantly...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh member of family that can infect humans. Recently, more contagious and pathogenic variants SARS-CoV-2 have been continuously emerging. Clinical candidates with high efficacy ready availability are still in urgent need. To identify potent anti-SARS-CoV-2 repurposing drugs, we evaluated antiviral 18 selective estrogen receptor modulators (SERMs) against infection. Six SERMs exhibited excellent effects Vero E6 cells...
The emergence of significant arboviruses and their spillover transmission to humans represent a major threat global public health. No approved drugs are available for the treatment in circulation today. repurposing clinically is one most rapid promising strategies identification effective treatments diseases caused by arboviruses. Here, we screened small-molecule compounds with anti-tick-borne encephalitis virus, West Nile yellow fever virus chikungunya activity from 2580 FDA-approved drugs....
Limb spasms are a common complication of stroke. It not only affects the quality life stroke survivors, but also brings an economic burden. Tuina combined with physical therapy is widely used in rehabilitation poststroke spasticity. However, there no supporting evidence for its efficacy and safety. This study aimed to evaluate effectiveness safety Tuinas treatment spasticity after stroke.Literature will be collected from following databases: China Biology Medicine (CBM), Wanfang Database,...
Abstract Innate immune responses triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play pivotal roles in the pathogenesis of COVID-19, while host factors including pro-inflammatory cytokines are critical for viral containment. By utilizing quantitative and qualitative models, we discovered that soluble secreted human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion viral-infected cells. Through cytokine screening, identified interleukin-1β...
Innate immune responses triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play pivotal roles in the pathogenesis of COVID-19, while host factors including proinflammatory cytokines are critical for viral containment. By utilizing quantitative and qualitative models, we discovered that soluble secreted human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion viral-infected cells. Through cytokine screening, identified interleukin-1β (IL-1β), a key...
Innate immune responses triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection play pivotal roles in the pathogenesis of COVID-19, while host factors including pro-inflammatory cytokines are critical for viral containment. By utilizing quantitative and qualitative models, we discovered that soluble secreted human monocytes potently inhibit SARS-CoV-2-induced cell-cell fusion viral-infected cells. Through cytokine screening, identified interleukin-1β (IL-1β), a...
Abstract Background As COVID-19 continues to spread rapidly in 2019, the risks human health cannot be underestimated. There is still lack of antiviral drugs for COVID-19, and development effective treatments urgent. Traditional Chinese Medicine (TCM) has been widely used treatment epidemic infectious diseases, The purpose this randomized controlled clinical trial will evaluate efficacy safety Hanshiyi Formula (HSYF) patients with COVID-19. Methods We conduct randomized, controlled, open,...