A5045684491- Lung Cancer Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Nanoplatforms for cancer theranostics
- Pleural and Pulmonary Diseases
- Lung Cancer Research Studies
- Inhalation and Respiratory Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Reproductive tract infections research
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Graphene and Nanomaterials Applications
- Occupational and environmental lung diseases
- Autophagy in Disease and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Radiation Therapy and Dosimetry
- Nosocomial Infections in ICU
- Immune cells in cancer
- Medicinal Plant Pharmacodynamics Research
- Respiratory viral infections research
- Ultrasound and Hyperthermia Applications
- Urinary Tract Infections Management
Sheng Jing Hospital
2025
Zhejiang University
2025
Qilu Hospital of Shandong University
2023-2024
Second Affiliated Hospital of Nanjing Medical University
2022-2023
Shandong Provincial Hospital
2019
Shandong University
2019
Fudan University Shanghai Cancer Center
2009-2018
Shanghai Medical College of Fudan University
2014
Pulmonary infection is a heterogeneous and complex infectious disease with high morbidity mortality worldwide. In clinical practice, considerable proportion of the etiology pulmonary unclear, microbiological diagnosis being challenging. Metagenomic next-generation sequencing detects all nucleic acids in sample an unbiased manner, revealing microbial community environment organisms improving detection diseases settings.
Recently, development of drug delivery systems for accurate antitumor drugs to tumor sites improve their efficacy has attracted great interest in the area cancer immunotherapy. In this report, an intelligent biodegradable hollow manganese dioxide (HMnO2) nanoparticle (NP) with a human umbilical cord mesenchymal stem cell (hUC-MSC) membrane coating was designed exert efficient chemo-immunotherapy treatment. A TAT peptide-modified structure constructed nuclear targeting. Our findings showed...
Novel antimicrobial strategies are urgently needed to treat extensively drug-resistant (XDR) bacterial infections due the high mortality rate and lack of effective therapeutic agents. Herein, nanoengineered human umbilical cord mesenchymal stem cells (hUC-MSCs), named PMZMU, designed as a sonosensitizer for synergistic sonodynamic-nano-antimicrobial therapy against gram-negative XDR bacteria. PMZMU is composed targeting peptide (UBI
To develop and validate an accurate computed tomography-based radiomics model for predicting high-grade (micropapillary/solid) patterns in T1-stage lung invasive adenocarcinoma (IAC) after propensity score matching (PSM). We enrolled 546 participants from 2 cohorts with histologically diagnosed IAC complete surgical resection between January 2020 August 2021. The patients were divided into non-high-grade groups matched using PSM. Matched patient HRCT images used to delineate regions of...
Abstract Background Chlamydia abortus is generally considered to cause abortion, stillbirth, and gestational sepsis in pregnant women, but it’s rare bloodstream infection pneumonia. Case presentation We present details of a patient with pneumonia caused by . Both blood next-generation sequencing (NGS) sputum NGS indicate infection. The received intravenous infusion piperacillin sodium tazobactam (4.5 g/8 h) moxifloxacin (0.4 g/d) oral oseltamivir (75 mg/day). Within one month follow-up, the...
Neutrophil membrane-encapsulated manganese dioxide nanoparticles for the treatment of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa .
Malignant pleural effusion (MPE) predicts advanced disease and poor prognosis, is usually diagnosed by medical thoracoscopy. It remains unclear whether the various representations visualized on thoracoscopy are reliable prognostic factors. The aim of this study was to evaluate factors for survival in patients who underwent MPE.The records consecutive with MPE from 2007 2015 at a tertiary hospital were reviewed theKaplan-Meier method Cox regression analysis used determine factors.A total 125...
e14581 Background: Cinical studies have confirmed that gefitinib, an EGFR-TKI, is effective for some advanced NSCLC patients. Patients with Asian ethnicity are reported to a higher response rate gefitinib monotherapy. However, incidence of interstitial lung disease, sometimes lethal, also found. The combination and radiotherapy has been observed synergistic, anti-proliferative effect against in vitro. This phase I study assessed the safety, clinical feasibility optimally tolerated regimen...
addition of chemotherapy and the emergence HPV positive demographic, current approach is observation in lieu surgery, presence negative interval PET imaging clinical findings.However, very little data exists for N3 subgroup disease.Aim: to determine efficacy (chemo)radiotherapy alone treatment nodal disease patients with head neck SCC Material Methods Data sources: A review contemporary English medical literature via MedLine, EMBASE using all combinations terms, Squamous cell carcinoma;...
Abstract The authors have withdrawn this preprint due to erroneous posting.
Abstract Background : Serum tumor markers are considered a negative prognostic factor in non-small cell lung cancer (NSCLC). Combined detection of serum and pleural fluid (PF) is rarely reported. The aim this study was to analyze the relationship between combined (SPF) prognosis advanced NSCLC. Results: High levels SPF CEA ( P = 0.001) , CYFRA21-1 CA-125 0.023) were adversely factors for overall survival (OS). 0.003) NSE 0.019) related worse progression-free (PFS). In multivariate analysis...
Severe asthma remains the bottleneck of clinical treatment. In order to deeply analyze pathogenesis severe asthma, so as develop new targeted drugs and evaluate curative effects, it is urgent establish an ideal animal model which great significance simulate pathophysiological characteristics patients with study potential therapeutic targets asthma. Here we summarized establishment method experimental application mouse...
Autophagy is a lysosomal mediated catabolic process that helps maintain cell balance and survival under extracellular or intracellular stress by degrading different cytoplasmic components. also significant way for the body to defend pathogen invasion, which swallowed phagosomes of host cells. When mature, they form autophagosomes, are fused with lysosomes autophagolysosomes. Autophagolysosomes degrade due action various hydrolases remove pathogens at same time. By interfering autophagy level...