A5100752815- Chronic Lymphocytic Leukemia Research
- Advanced Materials and Mechanics
- Chronic Myeloid Leukemia Treatments
- Advanced Sensor and Energy Harvesting Materials
- Lymphoma Diagnosis and Treatment
- Modular Robots and Swarm Intelligence
- Structural Analysis and Optimization
- Acute Myeloid Leukemia Research
- Cellular Mechanics and Interactions
- Acute Lymphoblastic Leukemia research
- 3D Printing in Biomedical Research
- HIV Research and Treatment
- Congenital heart defects research
- Chemical Synthesis and Characterization
- Innovative Energy Harvesting Technologies
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Radioactive element chemistry and processing
- HIV/AIDS drug development and treatment
- Click Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Micro and Nano Robotics
- RNA Interference and Gene Delivery
- HIV-related health complications and treatments
Brigham and Women's Hospital
2018-2025
Harvard University
1995-2025
University of Cambridge
2018-2025
Hebei University of Technology
2025
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Huaiyin Institute of Technology
2022-2024
Central South University
2009-2024
Linyi People's Hospital
2020-2024
Anhui University of Technology
2024
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used design new nanoparticles better understand existing ones. Modeled processes include the release of drugs at tumor site physical interaction between nanoparticle cancer cells. In this article, we provide an overview three different targeted methods (passive targeting, active targeting targeting),...
Circular RNAs (circRNAs) represent a class of endogenous noncoding that have recently been recognized as important regulators gene expression and pathological networks. However, their transcriptional activities functional mechanisms in cancer remain largely unknown. Here, we present results from global circRNA analysis patients with hepatocellular carcinoma (HCC). Using microarray, identified 226 differentially expressed circRNAs, which 189 were significantly upregulated 37 downregulated....
Cadmium (Cd), a toxic environmental contaminant, induces oxidative stress, leading to neurodegenerative disorders. Recently we have demonstrated that Cd neuronal apoptosis in part by activation of the mitogen-activated protein kineses (MAPK) and mammalian target rapamycin (mTOR) pathways. However, underlying mechanism remains elusive. Here show elevated intracellular calcium ion ([Ca2+]i) level PC12, SH-SY5Y cells primary murine neurons. BAPTA/AM, an Ca2+ chelator, abolished Cd-induced...
Trans-activating transcriptional activator (TAT), a cell-penetrating peptide, is extensively used for facilitating cellular uptake and nuclear targeting of drug delivery systems. However, the positively charged TAT peptide strongly interacts with serum components undergoes substantial phagocytosis by reticuloendothelial system, causing short blood circulation in vivo. In this work, an acid-active tumor nanoplatform DA-TAT-PECL developed to inhibit nonspecific interactions bloodstream....
Bistable structures associated with nonlinear deformation behavior, exemplified by the Venus flytrap and slap bracelet, can switch between different functional shapes upon actuation. Despite numerous efforts in modeling such large behavior of shells, roles mechanical geometric effects on bistability remain elusive. We demonstrate, through both theoretical analysis tabletop experiments, that two dimensionless parameters control bistability. Our work classifies conditions for bistability,...
The helix angle, chirality, and radius of helical ribbons are predicted with a comprehensive, three-dimensional analysis that incorporates elasticity, differential geometry, variational principles. In many biological engineered systems, ribbon helicity is commonplace may be driven by surface stress, residual strain, geometric or elastic mismatch between layers laminated composite. Unless coincident the principle axes ribbon, these anisotropies will lead to spontaneous, deformations....
An elastic sheet can be made to bend, twist, buckle, or wrinkle into a preprogrammed shape by employing judicious distribution of differential strains. The authors review the mechanics behind such self-assembly, examples from nature, and state-of-the-art fabrication techniques. Engineering based on these phenomena has great potential across applications ranging stretchable electronics microactuators drug delivery self-assembled biological implants.
Abstract Using a Burkitt lymphoma-like gene expression signature, we recently defined high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large lymphomas (GCB-DLBCL), which was enriched for MYC / BCL2 double-hit ( -DH). The genetic basis underlying MHG-DLBCL and their aggressive clinical behaviour remain unknown. We investigated 697 cases of DLBCL, particularly those with -DH n = 62) by targeted sequencing profiling. showed that DLBCL -DH,...
Vibration-based energy-harvesting technology, as an alternative power source, represents one of the most promising solutions to problem battery capacity limitations in wearable and implantable electronics, particular biomedical devices. Four primary energy transduction mechanisms are reviewed, namely piezoelectric, electromagnetic, electrostatic, triboelectric for vibration-based harvesters. Through generic modeling analyses, it is shown that various approaches can be used tune operation...
It is well established that the early malignant tumor invades surrounding extracellular matrix (ECM) in a manner depends upon material properties of constituent cells, ECM, and their interactions. Recent studies have capacity invading spheroids to evolve into coexistent solid-like, fluid-like, gas-like phases. Using breast cancer cell lines engineered here we show spheroid interior develops spatial temporal heterogeneities phase which, depending type density, ultimately result variety...
Abstract Background BCR-ABL1 T315I mutations confer resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Olverembatinib is a new potent TKI with preclinical activity against T315I-mutated CML. In phase 1/2 studies, we explored the safety and efficacy of olverembatinib Chinese adults TKI-resistant CML (CML-CP) accelerated (CML-AP). Methods 1 study, was orally administered once every other day 28-day cycles at 11 dose cohorts ranging from 60 mg, evaluated maximum...
Abstract MYC translocation occurs in 8–14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit (TH). DLBCL- / -DH/TH are largely germinal centre like subtype, but show variable clinical outcome, IG :: fusion significantly associated inferior survival. While -DH their cell-of-origin subtypes outcome. Intriguingly, only 40-50% DLBCL high protein expression (>70%). We studied 186 DLBCLs including 32...
Hypothalamic neuropeptide orexin has been implicated in the pathophysiology of psychiatric disorders and accumulating clinical evidence indicates a potential link between depression. However, exact role depression, particularly underlying neural substrates mechanisms, remains unknown. In this study, we reveal direct projection from hypothalamic orexinergic neurons to ventral pallidum (VP), structure that receives an increasing attention for its critical position rewarding processing, stress...
Abstract Angioimmunoblastic T‐cell lymphoma (AITL) is a neoplastic proliferation of T follicular helper cells with clinical and histological presentations suggesting role antigenic drive in its development. Genetically, it characterized by stepwise acquisition somatic mutations, early mutations involving epigenetic regulators ( TET2 , DNMT3A ) occurring haematopoietic stem cells, subsequent changes signaling molecules RHOA VAV1 PLCG1, CD28 critical for biology. To search evidence potential...