A5014647241- Drug Transport and Resistance Mechanisms
- Wound Healing and Treatments
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Organic and Molecular Conductors Research
- Vasculitis and related conditions
- Medicinal plant effects and applications
- X-ray Diffraction in Crystallography
- TGF-β signaling in diseases
- Magnetism in coordination complexes
- RNA modifications and cancer
- Crystallization and Solubility Studies
- Inhalation and Respiratory Drug Delivery
- Lung Cancer Diagnosis and Treatment
- Urticaria and Related Conditions
- Pancreatic and Hepatic Oncology Research
- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
Wuhan University
2019-2025
Zhongnan Hospital of Wuhan University
2019-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2025
Hubei University
2025
Fudan University Shanghai Cancer Center
2023-2024
Shandong Provincial Hospital
2018-2023
Shandong First Medical University
2020-2023
Jinan Infectious Disease Hospital
2021-2023
Shandong University
2018-2022
Idiopathic pulmonary fibrosis (IPF), a lethal respiratory disease with few treatment options, occurs due to repetitive microinjuries alveolar epithelial cells (AECs) and progresses an overwhelming deposition of extracellular matrix (ECM), ultimately resulting in fibrotic scars destroyed the architecture. Here, inhaled ribosomal protein-based mRNA nanoformulation is reported for clearing intrapulmonary ECM re-epithelializing disrupted epithelium, thereby reversing established foci IPF. The...
Abstract Metastasis accounts for the majority of cases cancer recurrence and death in patients with advanced non-small cell lung (NSCLC). Farnesoid X Receptor (FXR) is a bile acid nuclear receptor that was recently found to be upregulated NSCLC tissues. However, whether how FXR regulates metastasis remains unclear. In present study, it promoted migration, invasion, angiogenic ability cells vitro, increased mouse model vivo. Mechanistic investigation demonstrated specifically bound promoters...
Abstract Complete skin reconstruction is a hierarchically physiological assembly involving epidermis, dermis, vasculature, innervation, hair follicles, and sweat glands. Despite various wound dressings having been developed for regeneration, few works refer to the complete particularly lacking vasculatures follicles. Herein, an instructive dressing that integrates antibacterial property of quaternized chitin mechanical strength biological multifunction silk fibroin through layer‐by‐layer...
Reactive oxygen species (ROS) play a dual role in wound healing. They act as crucial signaling molecules and antimicrobial agents when present at moderate levels. However, excessive levels of ROS can hinder the healing process for individuals with diabetes. As result, targeting to maintain redox balance has become promising strategy improving recovery. Currently, no biomaterials have been reported simultaneously up-regulate down-regulate achieve broad-spectrum antibacterial antioxidant...
Abstract Background and objective The roles of bile acid microaspiration acid‐activated farnesoid X receptor (FXR) in the pathogenesis idiopathic pulmonary fibrosis (IPF) remain unclear. We hypothesized that acids activate alveolar epithelial cells (AECs) lung fibroblasts, which may be regulated by FXR activation. Methods Human AECs normal or IPF‐derived fibroblast were incubated with three major acids: lithocholic (LCA), deoxycholic (DCA) chenodeoxycholic (CDCA). injury indices,...
Abstract Farnesoid X receptor (FXR), a nuclear for maintaining bile acid homeostasis, has been recognized as tumor suppressor in enterohepatic tissues. However, its expression and functional role non-small cell lung cancer (NSCLC) remain unclear. We report that FXR is significantly increased NSCLC it predicts poor clinical outcomes patients. knockdown cells inhibited vitro proliferation, blocked xenograft growth nude mice, delayed the G1/S transition of cycle, whereas ectopic overexpression...
Abstract Background Novel chemotherapeutic drugs with good anti-tumor activity are of pressing need for bladder cancer treatment. In this study, plumbagin (PL), a natural plant-derived drug extracted from Chinese herbals, was identified as promising candidate human (BCa) chemotherapy. Methods The PL evaluated using series in vitro experiments, such MTT, transwell assay, flow cytometry, quantitative real-time PCR (qRT-PCR) and western blotting. We established xenograft tumors nude mice by...
Gastroesophageal reflux (GER) and microaspiration of duodenogastric refluxate have been recognized as a risk factor for pulmonary fibrosis. Recent evidence suggests that bile acid may contribute to the development lung However, molecular is scarce underlying mechanisms remain be elucidated. We recently demonstrated acids induce activation alveolar epithelial cells (AECs) fibroblasts in vitro In present study, rat model was established by weekly intratracheal instillation three major...
The farnesoid X receptor (FXR) regulates inflammation and immune responses in a subset of immune-mediated diseases. We previously reported that FXR expression promotes tumor cell proliferation non-small lung cancer (NSCLC). Here we study the relevance to microenvironment NSCLC. found an inverse correlation between PD-L1 cohort 408 NSCLC specimens; from this, identified subgroup FXRhighPD-L1low patients. showed downregulates via transrepression other mechanisms Cocultured with lines, effector...
SET and MYND domain‑containing protein 3 (SMYD3) is a lysine methyltransferase, its aberrant expression has been implicated in several malignancies. However, clinical biological roles non‑small cell lung cancer (NSCLC) remain unclear. In the present study, it was revealed that SMYD3 significantly upregulated NSCLC tissues, as compared with paired adjacent normal tissues. A high associated aggressive clinicopathological characteristics, well poor disease‑free survival overall (OS) patients....
Epithelial-mesenchymal transition (EMT) and cyclooxygenase-2 (COX-2) contribute to airway remodelling inflammation in chronic obstructive pulmonary disease (COPD). Recent data suggest that the farnesoid X receptor (FXR), a nuclear traditionally considered as bile acid-activated receptor, is also expressed non-classical acids target tissues with novel functions beyond regulating acid homeostasis. This study aimed investigate potential role of FXR development COPD, well factors affect...
Metastasis accounts for the majority of cancer-related deaths. Transforming growth factor <i>β</i> (TGF-<i>β</i>) is believed to promote late-stage cancer progression and metastasis by inducing epithelial-mesenchymal transition (EMT). We previously reported that MS80, a novel oligosaccharide sulfate, inhibits TGF-<i>β</i>1–induced pulmonary fibrosis binding TGF-<i>β</i>1. In our study MS80 effectively inhibited TGF-<i>β</i>/Smad signaling in lung cells, breast model cell lines. addition,...
Background Epithelial-mesenchymal transition (EMT) plays an important role in fibrosis, chronic inflammation, tumor metastasis, etc. Glycyrrhizin, active component extracted from licorice plant, has been reported to treat a variety of inflammatory reactions through inhibiting high-mobility group box1 (HMGB1), which suggested be significant mediator EMT process. However, whether glycyrrhizin affects the process or not remains unclear. Methods Human alveolar epithelial cell line A549 and...
Abstract Aldosterone plays a pivotal role in the pathogenesis of metabolic syndrome and cardiovascular disease; however, underlying mechanisms have not been clarified. Chemerin has characterized as an adipokine with crucial roles obesity-associated disorders homeostasis. The aim present study was to investigate direct effects aldosterone on chemerin expression secretion 3T3-L1 adipocytes identify potential signalling pathways involved. mRNA levels were measured using real-time PCR, whereas...
Anti‑programmed death‑1 (PD‑1)/programmed death‑ligand 1 (PD‑L1)‑directed immunotherapy has revolutionized the treatment of advanced non‑small cell lung cancer (NSCLC). However, predictive biomarkers are still lacking, particularly in identifying PD‑L1low/negative patients who will benefit from immunotherapy. It was previously reported that farnesoid X receptor (FXR) downregulated PD‑L1 expression NSCLC, and FXRhighPD‑L1low mouse Lewis carcinoma tumors showed an increased susceptibility to...