A5044801866- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- CAR-T cell therapy research
- Cancer therapeutics and mechanisms
- Osteoarthritis Treatment and Mechanisms
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Calcium signaling and nucleotide metabolism
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Inflammasome and immune disorders
- Pneumonia and Respiratory Infections
- Connective Tissue Growth Factor Research
- Biomarkers in Disease Mechanisms
- Advanced Energy Technologies and Civil Engineering Innovations
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Oil Palm Production and Sustainability
Fujian Medical University
2019-2024
Southern Medical University
2021-2024
Yale University
2024
Minzu University of China
2023
Yonsei University
2020
University of Southern Mississippi
2020
Sherwin Williams (United States)
2020
University of Houston
2020
KTH Royal Institute of Technology
2020
Goodyear (United States)
2020
Objective: Despite several clinicopathological factors being integrated as prognostic biomarkers, the individual variants and risk stratification have not been fully elucidated in lower grade glioma (LGG). With prevalence of gene expression profiling LGG, based on critical role immune microenvironment, aim our study was to develop an immune-related signature for prognosis prediction LGG. Methods: RNA-sequencing data from The Cancer Genome Atlas (TCGA), Tissue Expression (GTEx), Chinese...
Chemo-resistance is one of the major challenges in therapy small cell lung cancer (SCLC). Multiple mechanisms are thought to be involved chemo-resistance during SCLC treatment, but unfortunately, these have not been well elucidated. Herein, we investigated role miRNA resistance cells doxorubicin (Dox).MiRNA microarray analysis revealed that several miRNAs, including miR-7-5p, were specifically decreased Dox-resistant (H69AR) compared parental (H69). The expression level miR-7-5p was...
Abstract Objective Fibroblast‐like synoviocytes (FLS) are a major component of the hyperplastic synovial pannus that aggressively invades cartilage and bone during course rheumatoid arthritis (RA). Cyr61 (CCN1) is product growth factor–inducible immediate early gene involved in cell adhesion, proliferation, differentiation. However, role plays FLS proliferation has remained undetermined. The aim this study was to identify regulating derived from patients with RA. Methods Expression tissue...
T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional cell-recruiting chemokine system, suggesting existence cell exclusion mechanisms that impair infiltration. Using genome-wide vitro screening platform, we identified role for phospholipase A2 group 10 (PLA2G10) protein exclusion. PLA2G10 up-regulation is widespread cancers associated with poor infiltration tumor tissues....
The successful generation of T cell-mediated immunity for the treatment cancer has been a major focal point research. One critical strategies immunotherapy is to efficiently activate antigen-specific CD8 cells in immunosuppressive tumor environment. Here, we used transgenic OT-I/CD45.2/Rag-/- mice as source effector determine whether irradiation combined with adoptive cell transfer therapy could improve proliferation and function murine models. Local showed synergistic effect on growth...
Although abscopal tumor regression remains a rare phenomenon, interest in exploiting how radiation stimulates the immune system to induce systemic response is increasing. Here, we tested hypothesis that immunogenicity determined ability of radiotherapy effects. We established highly (MC-38 and E.G7-OVA) or poorly (LL/2 B16-F10) immunogenic models this study treated them with sham radiation, single dose 15 Gy, three fractions 5 Gy on consecutive days. Alterations microenvironment after were...
Background Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) was reported to be a novel immune checkpoint molecule comparable programmed cell death 1 ligand (PD-L1). However, its expression profile and immunosuppressive mechanisms in the glioma tumor microenvironment have not yet been fully explored. Objectives To identify potential function of Siglec-15 microenvironment. Methods We investigated PD-L1 tissues from 60 human patients GL261 models. Next, knockout macrophages mice...
Histamine is capable of modulating CNS arousal states by regulating neuronal excitability. In the current study, histamine action in ventromedial hypothalamus (VMH), its related ionic mechanisms, and possible facilitation estrogen were investigated using whole cell patch-clamp recording brain slices from ovariectomized female mice. Under clamp, a bath application (20 microM) caused membrane depolarization, associated with an increased resistance. some cells, depolarization was accompanied...
Abstract B7 homolog 4 (B7H4) is considered a negative regulator of immune responses, but the immunoregulatory role B7H4 in tumor microenvironment not clear. Here, we assessed expression cell types human breast cancer tissues and addressed its potential mechanisms CD8 T response. The results from flow cytometry immunohistochemistry demonstrated that was highly expressed 26 out 30 (86.7%) invasive ductal carcinomas, surface on cells inversely correlated with lymphocytes infiltration ( p <...
GB7 acetate is a galbulimima alkaloid obtained from Galbulimima belgraveana. However, information regarding its structure, biological activities, and related mechanisms not entirely available. A series of spectroscopic analyses, structural degradation, interconversion, crystallography were performed to identify the structure acetate. The MTT assay was applied measure cell proliferation on human colorectal cancer HCT 116 cells. expressions proteins measured by Western blotting. Transmission...
Lymphocyte antigen 6 complex, locus E (Ly6E) has been initially demonstrated to involve in T cell activity and impair viral infectivity. Recently, high expression levels of Ly6E have reported tumor microenvironment (TME) various types cancers. However, the immunoregulatory mechanism manipulating TME remains unknown. TCGA database Kaplan–Meier plotter were used evaluate correlation between cancer patient survival. After analyzing human breast tissues lines, we generated knockout (KO)...
Autophagy is an evolutionarily conserved mechanism for degrading and recycling different cellular components in both normal development stress conditions. Our recent research demonstrated that autophagy-mediated compartmental cytoplasmic deletion essential pollen germination. However, how autophagy regulates germination to ensure its fertility remains largely unknown. Here, we applied multi-omic analyses investigate the downstream pathways of process Although ATG2 ATG5 play similar roles...
The immunogenicity of the breast tumor microenvironment is clinically heterogeneous. insight into role tumor-infiltrating lymphocytes (TILs) might serve as a biomarker to predict survival benefit and enable optimal patient selection for immunotherapy. In this study, we aimed at characterizing cancer immune subtypes linked CD8 T cells associating with characteristics clinical outcomes. We analyzed gene signatures human using Genotype-Tissue Expression (GTEx) Cancer Genome Atlas (TCGA)...
Autophagy is an evolutionarily conserved mechanism for degrading and recycling various cellular components, functioning in both normal development stress conditions. This process tightly regulated by a set of autophagy-related (ATG) proteins, including ATG2 the ATG9 cycling system ATG5 ATG12 conjugation system. Our recent research demonstrated that autophagy-mediated compartmental cytoplasmic deletion essential pollen germination. However, precise mechanisms through which autophagy regulates...