A5024480574- Ocular Infections and Treatments
- Inflammatory mediators and NSAID effects
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Cancer Immunotherapy and Biomarkers
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Peripheral Artery Disease Management
- Pleural and Pulmonary Diseases
- Chemokine receptors and signaling
- Respiratory Support and Mechanisms
- Reproductive Biology and Fertility
- Pharmacogenetics and Drug Metabolism
- Histone Deacetylase Inhibitors Research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Philippine History and Culture
- Legionella and Acanthamoeba research
- Atherosclerosis and Cardiovascular Diseases
- Ultrasound in Clinical Applications
- Lymphatic System and Diseases
- Distributed Control Multi-Agent Systems
- Transport Systems and Technology
Chang Hua Hospital
2025
Fu Jen Catholic University
2022-2024
University of California, San Francisco
2023-2024
San Francisco Foundation
2023-2024
Tribhuvan University
2023
Fujian Medical University
2020-2023
Sunnybrook Health Science Centre
2022
Health Sciences Centre
2022
Fo Guang University
2022
National Taiwan University Hospital
2015-2020
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors, progesterone receptors and lacks HER2 overexpression. This absence of critical molecular targets poses significant challenges for conventional therapies. Immunotherapy, remarkably immune checkpoint blockade, offers promise TNBC treatment, but its efficacy remains limited. Epigenetic dysregulation, including altered DNA methylation, histone modifications, imbalances in regulators such as BET proteins,...
Abstract Butyrate, a known histone deacetylase inhibitor (HDACi) and product of fibre fermentation, is postulated to mediate the protective effect dietary against colon cancer. The transcription factor Sp1 target acetylation be associated with class I HDACs, including HDAC1. ubiquitous Sp1-regulated genes include those involved in cell cycle regulation, apoptosis lipogenesis: all major pathways cancer development. only acetylated residue lysine703 which resides DNA binding domain. Here we...
Abstract Background Neuropilin is a transmembrane receptor for vascular endothelial growth factor (VEGF) and expressed in normal cells upregulated cancer cells. Neuropilin-1 (NRP-1) has been shown to promote tumour cell migration survival colon response VEGF binding. The expression profiles of neuropilins, associated co-receptors known ligands have mapped three colorectal lines: Caco-2, HCT116 & HT29. We previously that butyrate, naturally occurring histone deacetylase inhibitor (HDACi)...
Neovascularization of the airways occurs in several inflammatory lung diseases, including asthma. Vascular endothelial growth factor (VEGF) plays an important role vascular remodeling asthmatic airways. Fatty acid binding protein 4 (FABP4 or aP2) is intracellular lipid chaperone that induced by VEGF cells. FABP4 exhibits a proangiogenic function vitro, but whether it modulation angiogenesis vivo not known. We hypothesized promotes VEGF-induced airway and investigated this hypothesis with use...
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Although its aetiology and pathogenesis remain unclear, recent studies suggest that dysfunction granulosa cells may partly be responsible. This study aimed to use cDNA microarray technology compare cell gene expression profiles with without PCOS identify genes aetiologically implicated PCOS. The cohort included 12 undergoing vitro fertilization, six Differential were classified by...
To conduct the first comprehensive cost-of-illness analysis for chronic kidney disease (CKD) management in Philippines, estimating direct medical, non-medical, and indirect costs across all stages renal replacement therapies (RRT). A combined top-down bottom-up quantitative approach was employed. Cost data were collected through facility surveys, literature reviews, expert panel input. The included cost estimated both non-diabetic diabetic CKD scenarios RRT modalities. Direct medical costs,...
Purpose: The purpose of this study was to identify pathogens associated with the 2022 conjunctivitis outbreak in Tamil Nadu, India. Methods: This prospective conducted November 2022. Patients presumed acute infectious presenting Aravind Eye Clinic Madurai, India, were eligible. Anterior nares and conjunctival samples from participants obtained processed for metagenomic RNA deep sequencing (RNA-seq). Results: Samples 29 patients sequenced. A pathogen identified 28/29 (97%) patients. Coxsackie...
Cyclooxygenase (COX)-2 has been implicated in tumour progression, angiogenesis and metastasis non-small cell lung cancer (NSCLC). We speculated that inhibition of COX-2 activity might reduce expression the pro-angiogenic factors vascular endothelial growth factor (VEGF) interleukin-8 (IL-8) cells. The levels IL-8, VEGF prostaglandin E2 (PGE2) were measured by ELISA. Expression COX-1 was determined Western blotting. Inhibition or knockdown achieved treating NSCLC cells with specific inhibitor...
Abstract BACKGROUND: Human papillomavirus (HPV) 16/18 infection is associated with nonsmoking lung cancer. In this study, the authors investigated a putative correlation between interleukin (IL)‐17 expression and HPV in clinical nonsmall cell cancer (NSCLC) tissues examined effects of on human NSCLC line. METHODS: IL‐17 was 79 tumor by immunohistochemistry. Growth rate, mRNA, secreting protein levels were also E6‐transfected H1299 cells. RESULTS: Immunohistochemical data showed that 48.1%...
Abstract Aim To evaluate epidemiology, pre‐admission characteristics and management of paediatric parapneumonic effusions ( PPE s) empyema in a tertiary pulmonary centre between 1993 2010. Methods Retrospective chart review study using thoracic database searches, with particular emphasis on characteristics, disease stage (simple or complex effusion empyema), general surgical procedures. Results One hundred children were eligible, exhibiting significant increase incidence from 0.5 to 2.6 per...
Abstract Background Previous reports have suggested that the VEGF receptor neuropilin-1 (NRP-1) is expressed in a singly dispersed subpopulation of cells normal colonic epithelium, but expression becomes dysregulated during colorectal carcinogenesis, with higher levels tumour suggestive poor prognosis. We noted spatial distribution and morphology if NRP-1 expressing resembles enteroendocrine (EEC) which are altered response to disease state including cancer irritable bowel syndrome (IBS)....
Abstract Background B7 homology 4 (B7-H4), a potential target for cancer therapy, has been demonstrated to inhibit T cell cytotoxicity in the early stages of breast cancer. However, B7-H4 manipulating tumor immune microenvironment (TIME) progression remains unknown. Methods We engineered cells with B7-H4-specific chimeric antigen receptors (CARs) and performed co-culture assay characterize expression level escaping from cytotoxicity. generated knockout (KO) overexpression (OE) determine...
Retinopathy of prematurity (ROP) is a leading cause blindness in children worldwide due to increasing survival rates premature infants. Initial suppression, followed by increased production the retinal vascular endothelial growth factor-A (VEGF) expression are key events that trigger pathological neovascularization ROP. Fatty acid binding protein 4 (FABP4) an intracellular lipid chaperone induced VEGF subset cells. FABP4 exhibits pro-angiogenic function cultured cells and airway...
The authors examined the role of volatility premiums in institutional investment portfolios. They began by defining and calculating standardized returns to exposure for a variety global asset markets. found that shorting offers not only very high statistically significant Sharpe ratio approximately 1.0 but also substantial tail risk. Although classic diversification benefits are limited, show modest allocations short could have enhanced long-term returns, one case increasing portfolio's combined 12%.
Purpose: The purpose of this study was to identify conjunctival transcriptome differences in patients with Acanthamoeba keratitis compared no known associated pathogen. Methods: host 9 (AK) is the 13 pathogen-free keratitis. Culture and/or confocal confirmed 8 participants AK who underwent metagenomic RNA sequencing as likely Cultures were negative all cases where did not a Results: Transcriptome analysis identified 36 genes differently expressed between and presumed sterile, or...
Understanding the mechanisms of human pluripotent stem cells (hPSCs) specification, development and differentiation to gametes are useful for elucidating causes infertility potential treatment. This study aims examine whether hPSCs can be induced DDX4 extracellularly expressing primordial germ cell-like (DDX4ec PGCLCs) further into ovarian follicle stage in a combined vitro vivo model. The transcriptional signatures show that these DDX4ec PGCLCs characteristic PGCs express folliculogenesis...
Some natural health products (NHPs) affect drug metabolism enzymes and transport proteins, potentially affecting the safety efficacy of or other NHPs. This study was undertaken to characterize effect uva-ursi ( Arctostaphylos ) on cytochrome P450 isozyme (3A4, 3A5, 3A7, 2C19, 19)-mediated P-glycoprotein (P-gp) transport. Three bulk 2 capsulated samples were obtained from commercial outlets. The capsules batched, herbal ground a common consistency. Aqueous methanol extracts freshly prepared....
The immunogenicity of the liver tumor microenvironment is clinically heterogeneous and mysterious. insight into role immune cells including tumor-infiltrating lymphocytes (TILs) chemokine networks, might enable optimal patient selection for immunotherapy. In this study, we aimed at characterizing cancer subtypes linked to chemokines associating with characteristics clinical outcomes. We analyzed signatures human using GTEx TCGA profiling 110 normal tissues 369 patients. performed...
1. The ventilatory response to carbon dioxide was measured in a group of patients with chronic obstructive airways disease using rebreathing method. 2. slope the curve obtained by plotting ventilation at successive half minutes against corresponding mean end tidal Pco2. 3. positively correlated (a) FEV1 and (b) reciprocal resting arterial Pco2, both these correlations being statistically significant. 4. Reference alone could explain more than 80% variation CO2 curve. This explained not...