A5053898252- Ocular Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- Legionella and Acanthamoeba research
- Retinal Imaging and Analysis
- Cytomegalovirus and herpesvirus research
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Contact Dermatitis and Allergies
- Retinal Diseases and Treatments
- Ophthalmology and Visual Health Research
- COVID-19 and healthcare impacts
- Dermatology and Skin Diseases
- Data-Driven Disease Surveillance
- Virology and Viral Diseases
- Traumatic Ocular and Foreign Body Injuries
- Rabies epidemiology and control
- Bacterial Identification and Susceptibility Testing
University of California, San Francisco
2005-2025
San Francisco Foundation
2004-2025
National Institute of Infectious Diseases
2023
United States Coast Guard
2023
Kobe University
2023
American Academy of Ophthalmology
2020
Aravind Eye Hospital
2019
University of California System
2019
Sinai Hospital
2005-2012
Johns Hopkins Hospital
2002-2008
Author(s): Ung, Lawson; Acharya, Nisha R; Agarwal, Tushar; Alfonso, Eduardo C; Bagga, Bhupesh; Bispo, Paulo Jm; Burton, Matthew J; Dart, John Kg; Doan, Thuy; Fleiszig, Suzanne Mj; Garg, Prashant; Gilmore, Michael S; Gritz, David Hazlett, Linda D; Iovieno, Alfonso; Jhanji, Vishal; Kempen, H; Lee, Cecilia Lietman, Thomas M; Margolis, Todd P; McLeod, Stephen Mehta, Jod Miller, Darlene; Pearlman, Eric; Prajna, Lalitha; N Venkatesh; Seitzman, Gerami Shanbhag, Swapna Sharma, Namrata; Savitri;...
Develop computer vision models for image-based differentiation of bacterial and fungal corneal ulcers compare their performance against human experts.
To compare the gene expression profiles of normal human corneal endothelium with Fuchs' endothelium, by using serial analysis (SAGE).Three pairs corneas were obtained from eye banks. Thirteen bisected buttons processed at time transplantation. The endothelia and Fuchs'-affected stripped, total RNA was isolated. Serial (SAGE) performed to identify quantify transcripts. Genes over- underexpressed limited P < 0.01 method Audic Claverie.A 19,136 tags identified 9,530 9,606 endothelium. 18...
We report a case of 53-year-old HIV-negative patient in San Francisco, California, USA, with no classic mpox prodromal symptoms or skin lesions who experienced fulminant, vision-threatening scleritis, keratitis, and uveitis. Deep sequence analysis identified monkeypox virus RNA the aqueous humor. confirmed on cornea sclera by PCR.
High-quality evidence regarding suppressive valacyclovir treatment in herpes zoster ophthalmicus (HZO) is necessary to guide care. To determine whether compared with placebo delays the occurrence of new or worsening stromal keratitis (SK), endothelial (EK), iritis, dendriform epithelial (DEK) during 12 months and if benefit persisted at 18 (secondary end point). The Zoster Eye Disease Study (ZEDS) was a randomized clinical trial conducted 95 sites from November 2017 June 2024....
Evidence regarding suppressive valacyclovir treatment on postherpetic neuralgia is necessary to guide care. To test the hypothesis that with 1000 mg/d of oral for 12 months reduces prevalence, severity, and duration compared placebo at 18 in participants herpes zoster ophthalmicus (HZO). Multicenter, placebo-controlled randomized clinical trial including 527 immunocompetent, nonpregnant adults history HZO rash, documented keratitis, or iritis within 1 year an estimated glomerular filtration...
Advances in diagnostic metagenomics have potential to transform how we diagnose ocular infections and care for patients. Metagenomic deep sequencing (MDS), an unbiased approach that interrogates all genomes a clinical sample, has been shown enhance detection of common unusual pathogens from the intraocular fluid patients with infectious uveitis other systemic infections.1Doan T. Wilson M.R. Crawford E.D. et al.Illuminating uveitis: metagenomic identifies rare pathogens.Genome Med. 2016; 8:...
Purpose: To study the feasibility and efficacy of a new remote wet lab for microsurgical education using corneal suturing task. Setting: Department Ophthalmology, University California San Francisco, California, USA. Design: Prospective randomized controlled study. Methods: Ten ophthalmology residents were stratified by postgraduate year to perform task consisting placing 4 cardinal sutures penetrating keratoplasty in porcine eyes with or without attending feedback. Subsequently, both groups...
Abstract Purpose of Review This study is to highlight the incidence corneal pseudomicrocysts in FDA-approved antibody–drug conjugates (ADCs), and success preventive therapies for related ocular surface adverse events (AEs). Recent Findings ADCs are an emerging class selective cancer that consist a potent cytotoxin connected monoclonal antibody (mAb) targets antigens expressed on malignant cells. Currently, there 11 with over 164 clinical trials. Various AEs have been attributed ADCs,...
Purpose: The purpose of this study was to identify pathogens associated with the 2022 conjunctivitis outbreak in Tamil Nadu, India. Methods: This prospective conducted November 2022. Patients presumed acute infectious presenting Aravind Eye Clinic Madurai, India, were eligible. Anterior nares and conjunctival samples from participants obtained processed for metagenomic RNA deep sequencing (RNA-seq). Results: Samples 29 patients sequenced. A pathogen identified 28/29 (97%) patients. Coxsackie...
Pulmonary immune responses are suited to determine mechanisms of lymphocyte elimination, as lung inflammation must be regulated tightly preserve gas exchange. The self-terminating response primed C57BL/6 mice intratracheal challenge with the T cell-dependent Ag sheep erythrocytes (SRBC) was used test importance apoptosis in pulmonary immunoregulation. Apoptosis alveolar and interstitial lymphocytes demonstrated morphologically, by three independent methods detect DNA fragmentation, surface...
To evaluate the ocular signs and tests for keratoconjunctivitis sicca (KCS) in absence of a gold standard.