A5039697421- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Infectious Diseases and Mycology
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Mycobacterium research and diagnosis
- Legionella and Acanthamoeba research
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Oral and Maxillofacial Pathology
- Actinomycetales infections and treatment
- Retinal and Optic Conditions
- Herpesvirus Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Plant Pathogens and Fungal Diseases
- Antifungal resistance and susceptibility
- Myxozoan Parasites in Aquatic Species
- Reconstructive Facial Surgery Techniques
- Veterinary Oncology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Diphtheria, Corynebacterium, and Tetanus
- Fungal Infections and Studies
- Sinusitis and nasal conditions
L V Prasad Eye Institute
2016-2025
University of Illinois Chicago
2024
Creative Commons
2023
Société de Réanimation de Langue Française
2014
Author(s): Ung, Lawson; Acharya, Nisha R; Agarwal, Tushar; Alfonso, Eduardo C; Bagga, Bhupesh; Bispo, Paulo Jm; Burton, Matthew J; Dart, John Kg; Doan, Thuy; Fleiszig, Suzanne Mj; Garg, Prashant; Gilmore, Michael S; Gritz, David Hazlett, Linda D; Iovieno, Alfonso; Jhanji, Vishal; Kempen, H; Lee, Cecilia Lietman, Thomas M; Margolis, Todd P; McLeod, Stephen Mehta, Jod Miller, Darlene; Pearlman, Eric; Prajna, Lalitha; N Venkatesh; Seitzman, Gerami Shanbhag, Swapna Sharma, Namrata; Savitri;...
Background Pythium insidiosum is a parafungus that causes keratitis resembling fungal keratitis. This study compares outcome in large cohort of patients with P treated antifungal drugs, to pilot group antibacterial antibiotics. Methods Between January 2014 and December 2016, 114 culture positive were included the study. A subset isolates was tested vitro for response nine antibiotics by disc diffusion E test. Patients topical natamycin 2014, 2015 up until mid 2016. Thereafter, received...
Acanthamoeba is an emerging pathogen, infamous for its resilience against antiprotozoal compounds, disinfectants and harsh environments. It known to cause keratitis, a sight-threatening, painful difficult treat corneal infection which often reported among contact lens wearers patients with ocular trauma. comprises over 24 species currently 23 genotypes (T1-T23) have been identified.This retrospective study was designed examine the recovered from keratitis (AK), determine presence of...
Keratitis, an inflammatory disease of the eye, when neglected could lead to sight-threatening complications and ultimately blindness. Globally, over a million people are affected by keratitis annually. Keratitis has microbial etiology is caused bacteria, fungi, viruses, etc. The present study compared ocular surface fungal microbiome healthy individuals with keratitis. Fungal microbiomes from conjunctival swabs corneal scrapings were generated using ITS2 region amplicons. Microbiomes...
Purpose: Heparanase (HPSE) cleaves heparan sulfate proteoglycans during herpes simplex virus-1 (HSV-1) infection, aiding in viral egress and disease progression. Its action has been well established vitro vivo models, but its relevance human patients remains unclear. This study aimed to specifically evaluate tear HPSE levels of with keratitis (HSK) correlate these findings a commonly used murine model. Methods: Tear samples from patient mice were collected at LV Prasad Eye Institute,...
Purpose The US Food and Drug Administration (USFDA) granted the miltefosine orphan drug designation in 2016 for treating Acanthamoeba keratitis. This study evaluates miltefosine's vitro efficacy against clinical isolates of from patients with keratitis its safety profile human corneal epithelial cell line to rationalize localized ocular application.
To report the outcome of Acanthamoeba keratitis, with early addition Photo-dynamic antimicrobial therapy Rose Bengal (PDAT-RB) to medical treatment (combination 0.02% Polyhexamethylene Biguanide (PH)and chlorhexidine(CH)). Patients were recruited based on infiltrate size being < 8 mm and limited mid stroma, 300µ, confirmed microbiological diagnosis. Along continuation PHMB + CH, patients also treated PDAT-RB twice a gap one week using 0.1% w/v RB green LED (525 nm) array immediately after...
To assess the sensitivity of potassium hydroxide and calcofluor white (KOH+CFW) mount in diagnosis Pythium keratitis concordance among microbiologists.Three microbiologists evaluated microscopic images KOH + CFW mounts confirmed cases fungal seen between January 2019 February 2021. The filaments were compared using specific differentiating features. specificity diagnosing infection along with microbiologists.Sixty consecutive growth fungus or insidiosum (n = 29) evaluated. correct...
Purpose: Neutrophils are known mediators of innate immunity, yet their effector function in herpesvirus infections remains poorly understood. Here, we elucidate the mechanistic action and pivotal role neutrophil extracellular traps (NETs) during herpes simplex virus type 1 (HSV-1) ocular infection. Methods: were collected from mice for HSV-1 infection, fluorescence imaging, immunoblotting assay. Tear samples healthy subjects patients with at L. V. Prasad Eye Institute, India, University...
This study was carried out as a part of an internal audit and is the largest series patients having keratoglobus, published in literature. Poor visual acuity indicates blinding nature disease.We report our experience with keratoglobus at tertiary eye care center India.Retrospective study.We analyzed adults pediatric (<16 years) seen during 2008-2012. The age, gender, consanguinity, presenting ocular signs, systemic associations, acuity, corneal topography, surgeries were...
Purpose: To report and analyze the outcomes of therapeutic deep anterior lamellar keratoplasty (DALK) in patients with advanced Acanthamoeba keratitis (AK). Methods: Medical records microbiologically confirmed AK, underwent DALK from 2004 to 2017, were reviewed data related early late outcome including complications retrieved. Outcome cases largest diameter infiltrate ≥8 mm at time surgery (advanced keratitis) analyzed compared those less severe (infiltrate size than 8 mm). Results: Out 23...