A5107969984- Advanced biosensing and bioanalysis techniques
- Genomics and Phylogenetic Studies
- Gait Recognition and Analysis
- Balance, Gait, and Falls Prevention
- Infrared Thermography in Medicine
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Nanopore and Nanochannel Transport Studies
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- Developmental Biology and Gene Regulation
- Microfluidic and Capillary Electrophoresis Applications
Centre for Cellular and Molecular Biology
2024
Amrita Vishwa Vidyapeetham
2020
Analysis of walking-related pathologies can be done using low-cost wearable sensors that could perceived as efficient and plausible methods for identifying gait abnormalities neurodegenerative disorders in low economy nations. In this study, we have used mobile phone contain both accelerometers well gyroscopes order to extract kinematic information analysis physiologically-relevant parameters classify stance swing among healthy volunteering subjects. Sufficient joint torque required each...
Abstract DNA methylation plays a key role in epigenetic regulation across lifeforms. Nanopore sequencing enables direct detection of base modifications. While multiple tools are currently available for studying 5-methylcytosine (5mC), there is paucity models that can detect 6-methyladenine (6mA) from raw nanopore data. Leveraging the motif-driven nature bacterial systems, we generated 6mA identification vastly surpass accuracy current best model. Our work study at single-base resolution new...
Abstract Long read sequencing technologies such as Oxford Nanopore (ONT) offer direct detection of DNA base modifications. While several tools and models have been developed to identify methylation from nanopore data, they are often restricted 5-methylcytosine (5mC) older flowcell (FC) chemistry. The performance accuracy newer models, including those by ONT, remain unknown, particularly for their new FC chemistry (R10.4.1) sampling rate (5kHz). Here, using a variety bacterial human datasets,...
Abstract Rapgef1 , a cell fate determinant and effector of multiple signaling events is essential for mammalian embryonic development. Here, we investigated the developmental role rapgef1 using zebrafish as model. We show that maternally expressed alternately spliced isoforms its two paralogs, rapgef1a rapgef1b development tissue-specific expression. CRISPR-Cas9 morpholino-based targeting resulted in defects brain somites. The morphants showed altered expression lineage determinants cranial...