A5056876383- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ocular Infections and Treatments
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Pain Mechanisms and Treatments
- Allergic Rhinitis and Sensitization
- Intraocular Surgery and Lenses
- Lymphatic System and Diseases
- Healthcare and Venom Research
- Ocular Diseases and Behçet’s Syndrome
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Acne and Rosacea Treatments and Effects
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Olfactory and Sensory Function Studies
- Neuropeptides and Animal Physiology
- Cytomegalovirus and herpesvirus research
- Laser Applications in Dentistry and Medicine
Tufts University
2016-2025
Tufts Medical Center
2016-2025
Massachusetts Eye and Ear Infirmary
2015-2024
Harvard University
2015-2024
Imaging Center
2015-2024
Smith-Kettlewell Eye Research Institute
2007-2022
Chestnut Hill College
2020
Heidelberg Engineering (Germany)
2019
Ocular Surface Center
2011-2018
Boston Children's Hospital
2012-2018
To evaluate the efficacy and safety of topical cenegermin (recombinant human nerve growth factor) in patients with neurotrophic keratopathy.Multicenter, randomized, double-masked, vehicle-controlled trial.Patients persistent epithelial defect or without stromal thinning.The NGF0214 trial, conducted among 11 sites United States, randomized 48 1:1 to 20 μg/ml vehicle eye drops, 6 drops daily for 8 weeks masked treatment. Follow-up was 24 weeks. Safety assessed all who received study drug....
purpose. Dendritic cells (DCs) comprise a system of highly efficient antigen-presenting (APCs) that initiate immune responses. The purpose this study was to examine the normal stroma for presence DCs and other bone marrow (BM)–derived cells. methods. Normal uninflamed corneas BALB/c murine strains were excised, immunofluorescence single- double-staining multiple markers performed examination by confocal microscopy. Corneal buttons placed in culture immunocytochemistry flow cytometry...
Transparency of the cornea, window eye, is a prerequisite for vision. Angiogenesis into normally avascular cornea incompatible with good vision and, therefore, one few tissues in human body where avascularity actively maintained. Here, we provide evidence critical mechanism contributing to corneal avascularity. VEGF receptor 3, present on lymphatic and proliferating blood vascular endothelium, strongly constitutively expressed by epithelium mechanistically responsible suppressing...
To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by vivo confocal microscopy (IVCM).IVCM central cornea was performed prospectively 53 eyes with bacterial (n = 23), fungal 13), Acanthamoeba 17) keratitis, 20 normal eyes, using laser microscopy. Density morphology dendritic-shaped cells (DCs) cornea, density, numbers, branching, tortuosity were assessed correlated. It...
To examine the widely accepted dogmas that corneal grafts lack passenger leukocytes or cells capable of migrating directly to lymph nodes (LNs), we tracked migration graft-derived transgenic green fluorescent protein (GFP; Iab) into draining LNs allogeneic (Iad) recipients. GFP+ were identified in cervical several hours after transplantation, and this traffic was significantly enhanced when placed inflamed recipient beds. Draining Iab+, CD45+, CD11c+, examination ungrafted corneas revealed...
Purpose: To evaluate density and morphology of corneal epithelial immune dendritic cells (DCs) in different subtypes dry eye disease (DED) using vivo confocal microscopy (IVCM). Methods: This retrospective study included 59 eyes 37 patients with DED 40 20 age-matched healthy controls. Based on clinical tests, were categorized into two subtypes: aqueous-deficient (n = 35) evaporative 24). For all subjects, images laser scanning (IVCM) the central cornea analyzed for DC (DC size, number...
Herpes simplex virus (HSV) infection is a classic example of latent viral in humans and experimental animal models. The HSV-1 latency-associated transcript (LAT) plays major role the latency reactivation cycle thus recurrent disease. Whether presence LAT leads to generation dysfunctional T cell responses trigeminal ganglia (TG) latently infected mice not known. To address this issue, we used LAT-positive [LAT(+)] LAT-deficient [LAT(-)] viruses evaluate effect on CD8 exhaustion TG mice....
The immunopathogenic mechanisms of dry eye disease (DED), one the most common ophthalmic conditions, is incompletely understood. Data from this prospective, double-masked, randomized trial demonstrate that targeting interleukin 1 (IL-1) by topical application an IL-1 antagonist efficacious in significantly reducing DED-related patient symptoms and corneal epitheliopathy.To evaluate safety efficacy treatment with receptor anakinra (Kineret; Amgen Inc) patients having DED associated meibomian...