A5100632418- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Radiomics and Machine Learning in Medical Imaging
- Viral gastroenteritis research and epidemiology
- Retinal and Macular Surgery
- Retinal Imaging and Analysis
- Animal Virus Infections Studies
- Gestational Diabetes Research and Management
- Pregnancy-related medical research
- Sperm and Testicular Function
- Obesity, Physical Activity, Diet
- Neonatal Respiratory Health Research
- Lymphatic System and Diseases
- Reproductive Biology and Fertility
- Retinal and Optic Conditions
- Amyotrophic Lateral Sclerosis Research
- Ocular Surface and Contact Lens
- Viral Infections and Vectors
- Retinal Development and Disorders
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- COVID-19 and Mental Health
- Liver Disease Diagnosis and Treatment
Xiangya Hospital Central South University
2019-2025
Xiamen University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Southern Medical University Shenzhen Hospital
2025
Central South University
2023-2025
Changhong (China)
2025
Sun Yat-sen University
1997-2024
Army Medical University
2014-2024
Liaocheng University
2023-2024
Anhui Medical University
2024
Purpose To report the ocular characteristics and presence of viral RNA severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens a patient with confirmed 2019 novel disease (COVID-19). Participant methods A 30-year-old man COVID-19 bilateral conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus swabs. The characteristics, dynamics were...
Transparency of the cornea, window eye, is a prerequisite for vision. Angiogenesis into normally avascular cornea incompatible with good vision and, therefore, one few tissues in human body where avascularity actively maintained. Here, we provide evidence critical mechanism contributing to corneal avascularity. VEGF receptor 3, present on lymphatic and proliferating blood vascular endothelium, strongly constitutively expressed by epithelium mechanistically responsible suppressing...
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are associated with high morbidity mortality. Menstrual blood-derived stem cells (MenSCs) have been shown to be good therapeutic tools in diseases such as ovarian failure cardiac fibrosis. However, relevant studies of MenSCs ALI not yet proceeded. We hypothesized that MenSC could attenuate the inflammation lipopolysaccharide (LPS)-induced promote repair damaged lung. model was induced by LPS C57 mice, saline or were...
<h3>Importance</h3> The ongoing COVID-19 pandemic and associated mitigation measures have disrupted access to psychiatric medications, particularly for women. <h3>Objective</h3> To assess the sex differences in trends prescribing of benzodiazepines, Z-hypnotics serotonergic (selective serotonin reuptake inhibitors [SSRIs] norepinephrine [SNRIs]), which are commonly prescribed anxiety, insomnia, depression. <h3>Design, Setting, Participants</h3> This cohort study used data from Clinformatics...
A novel coronavirus (SARS-CoV-2) was recently identified in patients with acute respiratory disease and spread quickly worldwide. specific rapid diagnostic method is important for early identification. The reverse-transcription recombinase-aided amplification (RT-RAA) assay a detection several pathogens. Assays were performed within 5–15 min as one-step single tube reaction at 39 °C. In this study, we established two RT-RAA assays the S orf1ab gene of SARS-CoV-2 using clinical specimens...
Periodontitis is an immune inflammatory disease that leads to progressive destruction of bone and connective tissue, accompanied by the dysfunction even loss periodontal ligament stem cells (PDLSCs). Pyroptosis mediated gasdermin-D (GSDMD) participates in pathogenesis diseases. However, whether pyroptosis mediates PDLSC loss, inflammation triggered involved pathological progression periodontitis remain unclear. Here, we found PDLSCs suffered GSDMD-dependent release interleukin-1β (IL-1β)...
Ophthalmologists have used fundus images to screen and diagnose eye diseases. However, different equipments ophthalmologists pose large variations the quality of images. Low-quality (LQ) degraded easily lead uncertainty in clinical screening generally increase risk misdiagnosis. Thus, real image restoration is worth studying. Unfortunately, benchmark has not been explored for this task so far. In paper, we investigate problem. Firstly, We establish a dataset, Real Fundus (RF), including 120...
Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties heritability estimate of up to 61%. The circulating levels IL-6 in blood have been associated an increased risk complex disease pathogenesis. We conducted two-staged, discovery replication meta genome-wide association study (GWAS) serum comprising 67 428 (ndiscovery = 52 654 nreplication 14 774) individuals European ancestry. inverse variance fixed effects based meta-analysis, followed...
Objective The accurate measurement of Cobb angles is crucial for the effective clinical management patients with adolescent idiopathic scoliosis (AIS). Lenke classification system plays a pivotal role in determining appropriate fusion levels treatment planning. However, presence interobserver variability and time‐intensive procedures presents challenges clinicians. purpose this study to compare accuracy our developed artificial intelligence AIS manual measurements validate its feasibility....
The effectiveness of the hepatitis E vaccine in high-risk groups, such as chronic B (CHB) patients, remains understudied. A key clinical manifestation CHB is persistent positivity surface antigen (HBsAg). We conducted a test-negative design study involving 2,926 HBsAg-positive individuals (born 1941-1991; median age 49.0; male-to-female ratio 1.4), identified through surveillance system, part phase 3 trial (NCT01014845) recombinant HEV 239 (Hecolin). This system monitored suspected cases and...
To develop an intelligent grading model for myopic maculopathy based on a long-tail learning framework, using the improved loss function LTBSoftmax. The addresses distribution problem in data to provide preliminary grading, aiming improve capability and efficiency. This study includes set of 7529 color fundus photographs. Experienced ophthalmologists meticulously annotated ground truth. A new was constructed LTBSoftmax, which predicts lesions by locally enhancing feature extraction with ND...
Abstract Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) intracranial volume (ICV). The underlying genetic influences shaping these during transition from childhood to adulthood are little understood, but might include both age-specific factors low-frequency variation. Here, we model developmental architecture HC, showing this genetically stable correlated with determinants ICV. Investigating up 46,000 children adults...
Purpose To compare the recurrence rate and surgical complications of retinopathy prematurity (ROP) between patients treated with intravitreal injection conbercept (IVC) ranibizumab (IVR) within 6 months. Methods A multicentral prospective, randomised controlled trial was applied from May 2017 to February 2019 for infants diagnosed as aggressive posterior-ROP, zone I or posterior II treatment-requiring ROP by binocular indirect ophthalmoscope RetCam3. These were assigned randomly receive...