A5100337013- Inflammasome and immune disorders
- Autophagy in Disease and Therapy
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Tryptophan and brain disorders
- Biomarkers in Disease Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Cardiovascular Disease and Adiposity
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Bowel Disease
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Flavonoids in Medical Research
- Cholinesterase and Neurodegenerative Diseases
- Bioactive natural compounds
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Immune Response and Inflammation
- Eosinophilic Esophagitis
Nankai University
2023-2025
First Affiliated Hospital of Bengbu Medical College
2023-2024
Bengbu Medical College
2024
Central South University
2019-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Second Xiangya Hospital of Central South University
2024
Shenzhen Pingle Orthopedic Hospital
2022-2024
First Affiliated Hospital of Chengdu Medical College
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chronic HIV-1 infection is generally characterized by progressive CD4+ T cell depletion due to direct and bystander death that closely associated with persistent replication an inflammatory environment in vivo. The mechanisms underlying the loss of cells patients chronic are incompletely understood. In this study, we simultaneously monitored caspase-1 caspase-3 activation circulating cells, which revealed pyroptotic apoptotic distinct populations different phenotypic characteristics. Levels...
Periodontitis is an immune inflammatory disease that leads to progressive destruction of bone and connective tissue, accompanied by the dysfunction even loss periodontal ligament stem cells (PDLSCs). Pyroptosis mediated gasdermin-D (GSDMD) participates in pathogenesis diseases. However, whether pyroptosis mediates PDLSC loss, inflammation triggered involved pathological progression periodontitis remain unclear. Here, we found PDLSCs suffered GSDMD-dependent release interleukin-1β (IL-1β)...
Liver cancer is a highly lethal malignancy. Despite considerable efforts made in recent years, the prognosis of patients with liver remains poor. Curcuma zedoaria (known as Ezhu Chinese) widely prescribed traditional Chinese medicine. Germacrone (GM) sesquiterpene constituent derived from essential oil Ezhu, and exerts anti-carcinogenic effects by inducing apoptosis various cells. The present study investigated potential mechanism GM HepG2 Cell Counting Kit-8, colony-formation lactate...
The inflammasome has been linked to diverse inflammatory and metabolic diseases, tight control of activation is necessary avoid excessive inflammation. Kynurenic acid (KA) a tryptophan metabolite in the kynurenine pathway. However, roles mechanisms regulation by KA have not yet fully elucidated. Here, we found that suppressed caspase-1 IL-1β production macrophages specifically inhibiting canonical noncanonical NLRP3 inflammasome. Mechanistically, reduced calcium mobilization through...
PI3K is a downstream target of multiple cell-surface receptors, which acts as crucial modulator both cell polarization and survival. PI3K/AKT signaling pathway commonly involved in cancer, atherosclerosis, other diseases. However, its role cardiovascular diseases, especially remains to be further investigated. To determine the effect on cellular inflammatory response oxidative stress, inhibitor (GDC0941) AKT (MK2206) were used. First, THP-1 cells incubated with ox-LDL (100 µg/ml) establish...
Radiation-induced enteropathy (RIE) is one of the most common and fatal complications abdominal radiotherapy, with no effective interventions available. Pyroptosis, a form proinflammatory regulated cell death, was recently found to play vital role in radiation-induced inflammation may represent novel therapeutic target for RIE. To investigate this, we that micheliolide (MCL) exerted anti-radiation effects vitro . Therefore, investigated both MCL RIE possible mechanisms by which it be...
Abstract The full activation of NLRP3 inflammasome needs two sequential signals: the fist priming signal and second assembly signal. Various stimuli including infections stress signals can provide However, how detects diverse becomes fully activated remain largely unknown. In this study, we found specially triggers acetylation NLRP3, which facilitates aggregation its interaction with ASC NEK7, thus promoting inflammasome. Meanwhile, by employing pharmacological molecular approaches,...
Peimine (PM) is a bioactive compound obtained from Fritillaria. It has been documented that PM exhibits potent antitumor properties against multiple cancers. However, the of in breast cancer and its associated mechanisms have not clarified.Proliferation apoptosis MCF-7 MCF-10A cells were detected by CCK8, colony formation, flow cytometry assays. Cytotoxicity was measured Lactate dehydrogenase (LDH) leakage assay. The level IL-1β IL-18 with ELISA kits. Western blotting real-time Polymerase...
Inflammatory bowel disease (IBD) has been reported to be associated with NLRP3 inflammasome activation. Therefore inhibiting activation could a new approach treat IBD. Inflammasome inhibitors NLRP3-IN-2, JC124, and 3,4-methylenedioxy-β-nitrostyrene (MNS) were previously exert anti-inflammatory effects in various models but not the dextran sulfate sodium (DSS)–induced colitis model. Here, we showed that MNS was more efficient secretion of interleukin-1β (IL-1β) by blocking oligomerization...
Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in development and pathogenesis colitis. Targeting represents potential therapeutic treatment. Our previous studies suggested acetylation is indispensable to activation, some acetyltransferase inhibitors could suppress activation. Here, we C646, an inhibitor histone p300, exerts anti-inflammatory effects DSS-induced colitis mice by targeting inflammasome. Mechanistically, C646 not only inhibits NF-κB...
PurposeOne of the best anticancer treatments available is radiotherapy, which can be used either alone or in conjunction with other forms treatment including chemotherapy and surgery. Nevertheless, a number biochemical physiological processes that react to ionizing radiation might provide tumor cells radioresistance, makes radiotherapy ineffective. It has been found CDKN1A regulates DNA damage repair, contributes radioresistance. However, precise mechanism still unknown. Therefore, this...
The link between Alzheimer's disease and depression has been confirmed by clinical epidemiological research. Therefore, our study examined the literary landscape prevalent themes in depression-related research works on through bibliometric analysis.
To investigate the effect and potential mechanisms of α-cyperone (CYP) on Crohn's disease (CD) -like colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) in mice.
Abstract Background and Aims Pyroptosis of intestinal epithelial cells is associated with barrier dysfunction the inflammatory symptoms Crohn's disease (CD). The natural plant monomer, nodakenin (Nod), inhibits NOD-like receptor protein 3 (NLRP3) expression, this study aimed to evaluate its effect on CD-like colitis, as well possible mechanisms. Methods Using TNBS intervention mice CD animal models, therapeutic Nod colitis in was explored through activity index (DAI) analysis, weight change,...
Objective To determine the impact and mechanism of HIV derived microRNA99 (miRNA99) on macrophages pyroptosis. Methods THP-1 cells were stimulated by phorbol ester (PMA) then cultured differentiated into sidewall attached macrophages; morphology phenotype CD11b measured microscopy flow cytometry. TLR8 RNAi plasmid was transfected to detected confocal fluorescence microscopy. The levels IL-18 IL-1β released ELISA. Western blot(WB) employed examine cleaved caspase-1 protein expression...