A5108133019- Algal biology and biofuel production
- Biofuel production and bioconversion
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Crystal structures of chemical compounds
- Polysaccharides and Plant Cell Walls
- Metal complexes synthesis and properties
- Forest ecology and management
- T-cell and B-cell Immunology
- Metal-Organic Frameworks: Synthesis and Applications
- Inflammasome and immune disorders
- Enzyme Production and Characterization
- Biocrusts and Microbial Ecology
- SARS-CoV-2 and COVID-19 Research
- Microbial Metabolic Engineering and Bioproduction
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Tree Root and Stability Studies
- Advanced Cellulose Research Studies
- Genetic and Kidney Cyst Diseases
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- IL-33, ST2, and ILC Pathways
- Peptidase Inhibition and Analysis
- Wound Healing and Treatments
University of South China
2024-2025
Qingdao University
2022-2025
Affiliated Hospital of Qingdao University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Beijing Normal University
2024
Chongqing Medical University
2019-2024
Huazhong University of Science and Technology
2008-2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2012-2023
Chinese Academy of Sciences
2011-2023
University of Chinese Academy of Sciences
2020-2023
Summary Microcystis is a cosmopolitan genus of cyanobacteria and occurs in many different forms. Large surface blooms the cyanobacterium are well known eutrophic lakes throughout globe. We evaluated role microcystins (MCs) promoting maintaining bloom‐forming cell aggregates at environmentally relevant MC concentrations (0.25–10 µg l −1 ). MCs significantly enhanced colony sizes. Colonial diameters microcystin‐RR (MC‐RR)‐treated cultures (at 1 ) were larger than control colonies, by factors...
The human FOXP3 molecule is an oligomeric transcriptional factor able to mediate activities that characterize T regulatory cells, a class of lymphocytes central the regulation immune responses. activity regulated at posttranslational level, in part by two histone acetyltransferases (HATs): TIP60 and p300. p300 work cooperatively regulate activity. Initially, interactions lead activation facilitate acetylation K327 TIP60, which functions as molecular switch allow change binding partners....
The rapid motorization of cities has led to the increasingly serious contradiction between supply and demand road resources, intersections have become main bottleneck traffic congestion. In general, capacity delay are often used as indicators improve intersection efficiency, but auxiliary such vehicle emissions that contribute sustainable development also need be considered. It is necessary evaluate efficiency through multiple measures reflect different aspects traffic, these may conflict...
New complexes [Pt(C(∧)N)Cl(dppa)] (1), and [Pt(C(∧)N)Cl(dppm)] (2), (C(∧)N. deprotonated 2-phenylpyridine; dppa. bis(diphenylphosphino)amine; dppm. bis(diphenylphosphino)methane) were suggested to have pentacoordinated geometry as investigated by NMR conductometry. Pharmacological effects of 1 2 evaluated for their proteasome-inhibitory apoptosis-inducing activities under in vitro vivo conditions, showing significant activity against purified 20S proteasome, while demonstrated superior...
Aims Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which susceptible to joint overloading, but the relationship between mechanical overloading and still remains elusive. The aim of our study was explore mechanism compression-induced hypertrophy. Methods In this study, temporomandibular (TMJ) model built through forced mandibular retrusion (FMR)-induced compression TMJ. Chondrocytes were also mechanically compressed vitro. role O-GlcNAcylation manifested...
BackgroundHepatic stellate cell (HSC) plays a key role in pathogenesis of liver fibrosis. During injury, hypoxia local micro-environment is inevitable. Hif-1α the transcriptional regulation factor that induces cell's adaptive responses to hypoxia. Recently, it was reported MAPK involved activity. AimsTo explore whether regulates HSC activation upon hypoxia, and affects Hif-1α-regulated signaling cascades, thus providing new targets for preventing MethodsHif-1α expression livers Schistosoma...
Cost-efficient saccharification is one of the main bottlenecks for industrial lignocellulose conversion. Clostridium thermocellum naturally degrades efficiently using cellulosome, a multiprotein supermolecular complex, and thus can be potentially used as low-cost catalyst saccharification. The use C. restrained due largely to inhibition hydrolysate cellobiose its cellulosome. Although supplementation beta-glucosidase may solve problem, production enzymes greatly complicates process also...
Alzheimer’s disease (AD) is a common neurodegenerative disorder that places heavy burden on patients and society. Hippocampal neuronal loss hallmark of AD progression. Therefore, understanding the mechanism underlying hippocampal death would be great importance for diagnosis treatment AD. This study aimed to explore molecular via which nuclear factor kappa β (NF-κB) promotes oxidative stress pyroptosis in We collected serum samples from 101 healthy elderly people 112 with at Affiliated...
TGF-β has been postulated to play an important role in the development of pancreatic cancers. More than 50% human cancers bear mutations Sma- and Mad-related protein (Smad) 4, a critical required for signaling. To evaluate vivo function cancers, we generated transgenic mouse model with pancreas-specific expression Smad7, specific inhibitor Through use elastase I promoter, directed tissue exogenous Smad7. Consistently, Smad7 was detected only pancreas mice, and, furthermore, phosphorylation...
Combination of antiangiogenesis and chemotherapy holds vast promise for effective inhibition tumor proliferation invasion. Herein, a multifunctional self-assembled nanosystem consisting amphiphilic c(RGDyK)-functionalized low-molecular-weight heparin-gambogic acid conjugate (cRHG) is developed, using c(RGDyK) peptide as αv β3 integrin targeting moiety to realize double-targeted delivery both cells angiogenic vasculature. cRHG with markedly decreased anticoagulant activity can self-assemble...
Cutaneous squamous cell carcinoma (CSCC) is the second most common skin cancer. Dihydromyricetin (DHM), a Rattan tea extract, has been shown to have antitumor activity with no obvious toxicity normal cells in vitro and vivo. However, its efficacy treatment of CSCC underlying mechanism not fully elucidated yet. In our study, DHM increased autophagic flux A431 cells, as evidenced by upregulation LC3-II downregulation P62/SQSTM1. Moreover, pharmacological or genetic blocking autophagy decreased...
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease. This study aims to analyze the value of procalcitonin (PCT), white blood cell count (WBC), and neutrophil-to-lymphocyte ratio (NLR) in differential diagnosis SLE with a bacterial infection.
Ischemic stroke is a major condition that remains extremely problematic to treat. A cerebral reperfusion injury becomes apparent after an ischemic accident when reoxygenation of the afflicted area produces pathological side effects are different than those induced by initial oxygen and nutrient deprivation insult. Pyroptosis form lytic programmed cell death distinct from apoptosis, which initiated inflammasomes depends on activation Caspase-1. Then, Caspase-1 mobilizes N-domain gasdermin D...