A5100383772- Ion Channels and Receptors
- Chronic Myeloid Leukemia Treatments
- Aquaculture disease management and microbiota
- RNA Interference and Gene Delivery
- Hemoglobin structure and function
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Chronic Lymphocytic Leukemia Research
- Advanced biosensing and bioanalysis techniques
- Endoplasmic Reticulum Stress and Disease
- Urinary Bladder and Prostate Research
- Immune Response and Inflammation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Mesenchymal stem cell research
- Statistical Methods in Clinical Trials
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Lung Cancer Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- Genetic and phenotypic traits in livestock
- Natural product bioactivities and synthesis
- Protein Interaction Studies and Fluorescence Analysis
Capital Medical University
2024-2025
Wenzhou University
2022-2025
China-Japan Friendship Hospital
2025
Northwestern Polytechnical University
2025
Jilin University of Chemical Technology
2025
Kunming University of Science and Technology
2014-2024
Second Hospital of Shandong University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Shanghai Chest Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Cytoplasmic vacuolization is commonly induced by bacteria and viruses, reflecting the complex interactions between pathogens host. However, their characteristics formation remain unclear. Nervous necrosis virus (NNV) infects more than 100 global fish species, causing enormous economic losses. Vacuolization a hallmark of NNV infection in host cells, but remains mystery. In this study, we developed simple aptamer labelling technique to identify red-spotted grouper (RGNNV) particles fixed live...
Abstract Fat‐tailed sheep have a unique characteristic of depositing fat in their tails. In the present study, we conducted genome‐wide association studies (GWAS) on traits related to tail deposition and body size Hulun Buir sheep. A total number 300 individuals belonging two fat‐tailed lines breed genotyped with Ovine Infinium HD SNP BeadChip were included current study. Two mixed models, one for continuous binary phenotypic traits, employed analyse ten that is, length (BL), height (BH),...
Runs of homozygosity (ROH) are contiguous homozygous genotype segments in the genome that present an individual since identical haplotypes inherited from each parent. The aim this study was to investigate frequency and distribution ROH genomes Landrace, Songliao black Yorkshire pigs. We calculated two types inbreeding coefficients their correlation, including coefficient based on (
Here, a complete set of recombinant fission yeast strains that coexpress each the 57 human cytochrome P450 (CYP) enzymes together with their natural electron transfer partner(s) was cloned. This strain collection tested two luminogenic probe substrates, and 31 CYPs (including orphan CYP2A7, CYP4A22 CYP20A1) were found to metabolize at least one these. Since other substrates are known for remaining enzymes, all now shown be active. Interestingly, CYP5A1 first time work on substrate than...
Context Paclitaxel (PTX) leads to chemotherapy brain (chemo-brain) which is characterised by cognitive impairment. It has been reported that necroptosis associated with impairment in some neurodegenerative diseases, but it not clear whether related the development of chemo-brain.Objective To investigate role and changes PTX-induced impairment.Materials methods C57bl/6n mice were randomly divided into five groups: control, vehicle, different concentrations PTX (6, 8, 10 mg/kg). Two additional...
The aim of this study was to investigate the structural characteristics and in vitro fermentation patterns polysaccharides from Boletus mushrooms. Polysaccharides were solubilized fruit bodies selected mushrooms auripes, B. bicolor, griseus using subcritical water extraction. characterized for their general physicochemical pattern, constituent monosaccharides molecular weight. A simulated model used utilization by gut microbiota consequent modulation microbial communities. Results showed...
Background The pelvis is one of the primary sites Ewing sarcoma (ES) and associated with poorer prognoses than extremities. Due to rarity this disease limited data available, prognostic factors pelvic ES remain controversial. Thus, study aimed identify independent factors, develop a nomogram for predicting survival rates in patients ES. Methods Using provided by Surveillance, Epidemiology, End Results (SEER) database, variables including age, sex, race, tumor size, stage, surgery,...
Circular RNAs (circRNAs), a subclass of noncoding RNAs, are reportedly involved in the progression various diseases. However, exact role circRIMS1, also termed hsa_circ_0132246, human bladder cancer remains unknown. By performing RNA sequencing comparing cell lines and normal uroepithelial cells, circRIMS1 was selected as research object. We further verified by qRT-PCR that is upregulated both tissue lines. Proliferation, colony-formation, Transwell migration, invasion, apoptosis, western...
The strawberry (Fragaria × ananassa) is an economically important fruit throughout the world. large R2R3-MYB gene family participates in a variety of plant functions, including anthocyanin biosynthesis. present study first genome-wide analysis MYB octoploid and describes identification characterization members using recently sequenced F. ananassa genome. Specifically, we aimed to identify key MYBs involved petal coloration pink-flowered strawberry, which increases its ornamental value. A...
The protective effect of Cannabidiol on Parkinson’s disease (PD) has been found in recent study. However, the specific mechanism PD nerve damage require further exploration. This study aims to investigate MMP-induced Neural Cells (SH-SY5Y) mitochondrial dysfunction. MMP + and were used treat SH-SY5Y cells, cells viability was measured by MTT assay. expression Tyrosine hydroxylase (TH) western blotting Immunofluorescence staining. relationship among Cannabidiol, Silent mating type information...
Alzheimer’s disease (AD) is a common neurodegenerative disorder that places heavy burden on patients and society. Hippocampal neuronal loss hallmark of AD progression. Therefore, understanding the mechanism underlying hippocampal death would be great importance for diagnosis treatment AD. This study aimed to explore molecular via which nuclear factor kappa β (NF-κB) promotes oxidative stress pyroptosis in We collected serum samples from 101 healthy elderly people 112 with at Affiliated...
Lung adenocarcinoma (LUAD) is a heterogeneous disease. Our study aimed to understand the unique molecular features of preinvasive invasive LUAD subtypes. We retrospectively analyzed clinical, histopathological, and data 3,254 Chinese patients with lesions (n = 252), minimally adenocarcinomas 479), 2,523). Molecular were elucidated using targeted 68-gene next-generation sequencing panel. findings revealed four lesion-predominant gene mutations, including MAP2K1 insertion-deletions (indels),...
Wenchang chickens, a native breed in the Hainan province of China, are famous for their meat quality and adaptability to tropical conditions. For effective management conservation, present study, we systematically investigated characteristics genetic variations runs homozygosity (ROH) along genome using re-sequenced whole-genome sequencing data from 235 chickens. A total 16,511,769 single nucleotide polymorphisms (SNPs) 53,506 ROH segments were identified all individuals, chicken mainly...
Through the analysis of electron paramagnetic resonance (EPR) spectra from patients with pigment gallstones, it was found that both Fe3+ and Cu2+ signals were detected in gallstone powder, exhibiting relatively high intensity. The EPR signal for Fe(III) showed g = 4.18 ΔHpp 4.85 mT, presenting an asymmetric high-spin spectrum; Cu(II), g‖=2.36 g⊥=2.15 observed. This study explored relationship between bile pigments /Cu2+ ions, noting routine health examinations typically do not include...