A5003176186- Aquaculture disease management and microbiota
- interferon and immune responses
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Invertebrate Immune Response Mechanisms
- Toxoplasma gondii Research Studies
- Vibrio bacteria research studies
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Antimicrobial Peptides and Activities
- NF-κB Signaling Pathways
- Heat shock proteins research
- Bacteriophages and microbial interactions
- Cell death mechanisms and regulation
- Protease and Inhibitor Mechanisms
- Genomics and Phylogenetic Studies
- Herpesvirus Infections and Treatments
South China Agricultural University
2016-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021-2025
Qingdao National Laboratory for Marine Science and Technology
2016-2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2021-2024
Key Laboratory of Guangdong Province
2020-2024
University of Macau
2024
Agriculture Fisheries and Conservation Department
2020-2023
Sun Yat-sen University
2008-2019
South China Sea Institute Of Oceanology
2010-2017
Institute of Oceanology
2010-2017
Abstract Background Orange-spotted grouper ( Epinephelus coioides ) is an economically important marine fish cultured in China and Southeast Asian countries. The emergence of infectious viral diseases, including iridovirus betanodavirus, have severely affected food products based on this species, causing heavy economic losses. Limited available information the genomics E. has hampered understanding molecular mechanisms that underlie host-virus interactions. In study, we used a 454...
Iridovirus has become a great threat to global aquaculture due its high mortality, while the molecular events in virus pathogenesis are not well elucidated. Here, multi-omics approach was performed with Singapore grouper iridovirus (SGIV)-infected groupers, and roles of key metabolites were investigated. SGIV induced obvious histopathological damage changes metabolic enzymes liver. Besides, significantly decreased contents lipid droplets, triglycerides, cholesterol, lipoprotein. Metabolome...
Viral nervous necrosis (VNN) is an acute and serious fish disease caused by virus (NNV) which has been reported massive mortality in more than fifty teleost species worldwide. VNN causes damage of vacuolation to central system (CNS) cells fish. It difficult identify the specific type cell targeted NNV, decipher host immune response because functional diversity highly complex anatomical cellular composition CNS. In this study, we found that red spotted grouper NNV (RGNNV) mainly attacked...
Cytoplasmic vacuolization is commonly induced by bacteria and viruses, reflecting the complex interactions between pathogens host. However, their characteristics formation remain unclear. Nervous necrosis virus (NNV) infects more than 100 global fish species, causing enormous economic losses. Vacuolization a hallmark of NNV infection in host cells, but remains mystery. In this study, we developed simple aptamer labelling technique to identify red-spotted grouper (RGNNV) particles fixed live...
Autophagy is an important biological activity that maintains homeostasis in eukaryotic cells. However, little known about the functions of fish autophagy-related genes (Atgs). In this study, we cloned and characterized Atg5, a key gene autophagy superfamily, from orange-spotted grouper (Epinephelus coioides) (EcAtg5). EcAtg5 encoded 275-amino acid protein shared 94% 81% identity to seabass (Lates calcarifer) humans (Homo sapiens), respectively. The transcription level was significantly...