A5074779107- Animal Virus Infections Studies
- Plant Molecular Biology Research
- Inflammatory Bowel Disease
- Parkinson's Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Magnolia and Illicium research
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Genetic diversity and population structure
- interferon and immune responses
- Lipid metabolism and disorders
- Virology and Viral Diseases
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Animal Vocal Communication and Behavior
- 2D Materials and Applications
- Cell Adhesion Molecules Research
- Nuclear Receptors and Signaling
- Cardiac Imaging and Diagnostics
- Cerebrovascular and genetic disorders
- Genetic Neurodegenerative Diseases
- 14-3-3 protein interactions
- Phagocytosis and Immune Regulation
South China Agricultural University
2024-2025
Hebei Medical University
2021-2024
Second Hospital of Hebei Medical University
2021-2024
Wenzhou University
2024
South China Normal University
2018-2023
Jiangsu University
2019
Chang Gung University
2017
Guangdong Ocean University
2008-2009
Background Ferroptosis is a novel form of regulated cell death involved in tumor progression. The role ferroptosis-related lncRNAs hepatocellular carcinoma (HCC) remains unclear. Methods RNA-seq and clinical data for HCC patients were downloaded from Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal. Bioinformatics methods, including weighted gene coexpression network analysis (WGCNA), Cox regression, least absolute shrinkage selection operator (LASSO) analysis, used to identify...
Geminiviruses, such as beet severe curly top virus (BSCTV), are a group of DNA viruses that cause plant diseases and agricultural losses. The C4 protein is major symptom determinant in several geminiviruses; however, its regulatory mechanism molecular function cells remain unclear. Here, we show BSCTV S-acylated planta, this post-translational lipid modification necessary for membrane localization functions, especially regulation shoot development host plants. Furthermore, the form interacts...
Abstract Brassinosteroids (BRs) are important plant hormones involved in many aspects of development. Here, we show that BRASSINOSTEROID SIGNALING KINASEs (BSKs), key components the BR pathway, precisely controlled via de‐S‐acylation mediated by defense hormone salicylic acid (SA). Most Arabidopsis BSK members substrates S‐acylation, a reversible protein lipidation is essential for their membrane localization and physiological function. We establish SA interferes with plasma function BSKs...
Abstract Crohn's disease (CD) is a complex autoimmune disorder presumed to be driven by interactions of genetic, immune, microbial and even environmental factors. Intrinsic molecular mechanisms in CD, however, remain poorly understood. The identification novel biomarkers CD cases based on larger samples through machine learning approaches may inform the diagnosis treatment diseases. A comprehensive analysis was conducted all datasets Gene Expression Omnibus (GEO); our team then used robust...
18F-9-Fluoropropyl-(+)-dihydrotetrabenazine [18F-FP-(+)-DTBZ] positron emission tomography (PET) has been shown to detect dopaminergic neuron loss associated with Parkinson's disease (PD) in human and neurotoxin-induced animal models. A polyphenol compound, magnolol, was recently proposed as having a potentially restorative effect 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- or 6-hydroxydopamine-treated In this study, 18F-FP-(+)-DTBZ PET used determine the therapeutic efficacy of...
Abstract Protein S-acylation is an important post-translational modification in eukaryotes, regulating the subcellular localization, trafficking, stability, and activity of substrate proteins. The dynamic regulation this reversible mediated inversely by protein S-acyltransferases de-S-acylation enzymes, but mechanism remains unclear plant cells. Here, we characterized a group putative enzymes Arabidopsis thaliana, including 11 members Alpha/Beta Hydrolase Domain-containing 17-like acyl...
Background: Ulcerative colitis (UC) is a chronic, complicated, inflammatory disease with an increasing incidence and prevalence worldwide. However, the intrinsic molecular mechanisms underlying pathogenesis of UC have not yet been fully elucidated. Methods: All datasets published in GEO database were analyzed summarized. Subsequently, robust rank aggregation (RRA) method was used to identify differentially expressed genes (DEGs) between patients controls. Gene functional annotation PPI...
Genetic diversity and population structure of the peanut worm (Sipunculus nudus) were investi- gated by using 536 base-pair fragments mitochondrial 16S ribosomal gene. Populations collected from three locations along southern coast China - Beihai, Sanya, Xiamen. Amplified polymerase chain reaction products sequenced in both directions data analyzed ClustalX, Arlequin, MEGA. A total 69 polymorphic sites 21 distinct haplotypes revealed. The mean haplotype nucleotide pop- ulations 0.814% 0.37%,...
Exocyst, a protein complex, plays crucial role in various cellular functions, including cell polarization, migration, invasion, cytokinesis, and autophagy. Sec3, known as Exoc1, is key subunit of the Exocyst complex can be involved survival apoptosis. In this study, two subtypes Sec3 were isolated from Epinephelus coioides, an important marine fish China. The E. coioides was explored during Singapore grouper iridovirus (SGIV) infection, pathogen which could induce 90% mortality. sequences...
Exocyst, a protein complex, plays crucial role in various cellular functions, including cell polarization, migration, invasion, cytokinesis, and autophagy. Sec3, known as Exoc1, is key subunit of the Exocyst complex can be involved survival apoptosis. In this study, two subtypes Sec3 were isolated from Epinephelus coioides, an important marine fish China. The E. coioides was explored during Singapore grouper iridovirus (SGIV) infection, pathogen which could induce 90% mortality. sequences...
New 2D, 3D and cluster structures of Li 2 S were found by IM ODE. The stabilities electronic properties novel explored using DFT calculations.