A5100770547- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Biochemical Acid Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Phagocytosis and Immune Regulation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Cardiac electrophysiology and arrhythmias
- China's Ethnic Minorities and Relations
- Extracellular vesicles in disease
- Gallbladder and Bile Duct Disorders
- PARP inhibition in cancer therapy
- Pharmacological Effects of Natural Compounds
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Alcoholism and Thiamine Deficiency
- Cardiac Arrhythmias and Treatments
- Infection Control and Ventilation
Hebei Medical University
2008-2024
Second Hospital of Hebei Medical University
2008-2024
Shenzhen Institutes of Advanced Technology
2020
Chinese Academy of Sciences
2020
A series of pneumonia cases caused by 2019 novel coronavirus (2019-nCoV, also named COVID-19) are being reported globally. Based on recent publications,1–3 the most common symptoms in patients infected 2019-nCoV were fever and cough. However, incidence other clinical features differs different reports. To address this issue, we collected data from three reports1–3 compared accordingly. We found that leucopenia, diarrhoea studies showed a statistically significant difference (table 1). Among...
Background Ferroptosis is a novel form of regulated cell death involved in tumor progression. The role ferroptosis-related lncRNAs hepatocellular carcinoma (HCC) remains unclear. Methods RNA-seq and clinical data for HCC patients were downloaded from Cancer Genome Atlas (TCGA) Genomic Data Commons (GDC) portal. Bioinformatics methods, including weighted gene coexpression network analysis (WGCNA), Cox regression, least absolute shrinkage selection operator (LASSO) analysis, used to identify...
Understanding how the coronaviruses invade our body is an essential point, and expression profile of receptor may help us to find where coronavirus infects body. We found that receptors, including angiotensin-converting enzyme 2 (ACE2) for SARS-CoV SARS-Cov-2, are digestion-related enzymes in human enterocytes. Coronaviruses continually altering binding modes during their evolution, but potential target cell small intestine constant when lung inconstant. Enterocytes act as a conserved...
Radiation therapy, one of the major treatments for liver cancer, causes DNA damage and cell death. Since cancer cells have a strong capacity to repair irradiative injury, new medicines enhance this treatment are urgently required. In study, we investigated effect NU7441, synthetic small-molecule compound, as specific inhibitor DNA-dependent protein kinase (DNA-PK) in radiosensitization hepatocellular carcinoma HepG2 cells.Cell Counting Kit-8 (CCK-8) was first used evaluate proliferation...
Summary The outbreak of pneumonia caused by the 2019 Novel Coronavirus (2019-nCoV) was reported in Wuhan City, China. However, clinical symptoms varied different reports. Based on results inter-group difference test, we found that incidence diarrhea differed three recent As 2019-nCoV utilizes same cell entry receptor ACE2 as severe acute respiratory syndrome coronavirus (SARS-CoV) and tightly controls intestinal inflammation, to trace route infection mediated 2019-nCoV, used single-cell RNA...
Abstract The Capsule Endoscopy Group of the Chinese Society Digestive has issued recommendations for capsule endoscopy (CE) practice during COVID-19 pandemic to standardize workflow, preventive strategies, and management a CE unit in so doing, ensure safety both medical staff patients.
<h3>Background</h3> Several recent studies suggested that gut microbiota are crucial in modulating immune responses to COVID-19 vaccination. However, the majority of these have focused on younger populations, and effects vaccine-induced elderly remain elusive. <h3>Methods</h3> We recruited 25 subjects (aged 64-86 years) who required fourth dose a recombinant vaccine (ZF2001) for multi-omics analysis, including metagenomics, metabolomics, single-cell RNA sequencing (scRNA-seq), T-cell...
<title>Abstract</title> Matrix stiffness can have significant effects on cell behavior, regulating processes such as proliferation, differentiation, migration, and extracellular matrix production; however, less is known regarding the epigenomic transcriptional regulation underling effect of phenotypic shifts. In present study, we utilized an <italic>in vitro</italic> system to assess shifts hepatic stellate cells (HSCs) following changes in stiffness, addition integrating multi-omics with...
Expression of nitric oxide synthase protein and gene in the splanchnic organs liver cirrhosis portal hypertensive rats
Computed tomography portal venography (CTPV) shows potential in detecting varices that need treatment and their drainage pathways. However, its agreement with endoscopy requires further study. We investigated the feasibility of CTPV as an alternative tool to screening gastroesophageal (GEVs) developed a CTPV-based model provide less invasive assessment endotherapy for cirrhotic patients GEVs.The study included 33 recent history variceal hemorrhage. The presence, grade, classification GEVs on...
AIM:To study cellular immune function in patients with posthepatitic cirrhosis (PHC) and its relationship different types of liver damage. METHODS: Fifty-one PHC, including 20 cases Child-Pugh class A, 18 B, 13 C 22 normal subjects as controls were studied.After peripheral blood mononuclear cells isolated by Ficoll-Hypaque gradient centrifugation, lymphocyte transformation (LT) test, IL-2 activity NK cell measured the 3 H-TdR incorporation technique.RESULTS: Changes LT stimulation index...
Expert consensus proposes an emergency treatment protocol for portal hypertension bleeding. Herein, the procedures, which include first aid, medical, interventional, and surgical treatments, are described. In addition, indications, contraindications, operating norms, precautions, prevention of complications described to optimize aid process.
Objective To study the changes of plasma endotoxin and procalcitonin in patients with esophagogastric varices provide a theoretical basis for prophylactic antibiotics after endoscopic treatment. Methods Fifty cases esophageal gastric accepted treatment. The were divided into antibiotic group (32 cases) non-antibiotic (18 cases). measured before on first day 7th treatment. Results The levels not significantly different treatment compared preoperative group. But group, increased...
# Epsilon waves detected by various electrocardiographic recording methods {#article-title-2} Objective We analysed the shape and distribution of epsilon three in patients with arrhythmogenic right ventricular cardiomyopathy. Methods Thirty-two who met recognized diagnostic criteria for cardiomyopathy were included this study (24 men 8 women; mean age, 42.3 ± 12.9 years). standard 12-lead electrocardiography (S-ECG), right-sided precordial lead (R-ECG), Fontaine bipolar (F-ECG). Results...