A5000704859- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Telomeres, Telomerase, and Senescence
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Cancer Mechanisms and Therapy
- Vascular anomalies and interventions
- Plant tissue culture and regeneration
- Gallbladder and Bile Duct Disorders
- Abdominal vascular conditions and treatments
- Cancer-related gene regulation
- Liver Diseases and Immunity
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastroesophageal reflux and treatments
- Berberine and alkaloids research
Xijing Hospital
2014-2025
Air Force Medical University
2015-2025
National Clinical Research Center for Digestive Diseases
2017-2025
ShenZhen People’s Hospital
2023
Changzhi University
2005-2021
State Key Laboratory of Cancer Biology
2021
TU Dresden
2021
Southwest Hospital
2005-2011
Army Medical University
2005-2011
MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function of miR-218 gastric cancer (GC) expression is decreased along with one its host genes, Slit3 metastatic GC. However, Robo1, several Slit receptors, negatively regulated by miR-218, thus establishing a negative feedback loop. Decreased levels eliminate Robo1 repression, which activates Slit-Robo1 pathway through interaction between Slit2, triggering The restoration suppresses inhibits cell invasion...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort...
Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying aberrant and potential functions remain uncertain.The role mechanism GC metastasis were investigated epithelial cells, cell lines an experimental animal model by gain function loss function. Upstream downstream targets selected bioinformatics identified luciferase reporter assay, electrophoretic mobility shift assay chromatin immunoprecipitation PCR. The...
Background Use of TIPSS is associated with increases in ammonia concentration and hepatic encephalopathy (HE) risk. l-ornithine-l-aspartate (LOLA) effective reducing concentration. Aim To evaluate the effects LOLA on venous after TIPSS. Methods The included patients were randomised to receive or no-LOLA treatment for 7 days. Fasting post-prandial levels primary outcomes. Psychometric performance, post-TIPSS HE, liver renal function assessed as secondary Results Of 133 cirrhotic who received...
Patients with recurrent or refractory ascites can benefit from transjugular intrahepatic portosystemic shunt (TIPS). However, the value of TIPS for patients large remains unclear. This retrospective multicenter study included who underwent medicine plus large-volume paracentesis (medicine + LVP) between January 2014 and December 2022 at five centers. The primary endpoint was recurrence worsening ascites. secondary endpoints were liver-related death, all-cause hemorrhage, overt hepatic...
We report a rare case of refractory gastrointestinal bleeding due to portal hypertension caused by gastroduodenal artery-superior mesenteric vein fistula. A 54-year-old woman with 6-year history haematemesis and haematochezia was admitted after her most recent episode. She had endured over 10 episodes bleeding, undergone multiple endoscopic procedures received one percutaneous transhepatic variceal embolisation. One week before admission, she experienced another episode, necessitating an...
The transjugular intrahepatic portal collateral-systemic shunt (transcollateral TIPS) is used to treat hypertension-related complications in patients with cavernous transformation of the vein (CTPV) and whose main cannot be recanalized. It still not clear whether transcollateral TIPS can as effective recanalization-transjugular portosystemic (PVR-TIPS). This study aimed evaluate efficacy safety treatment refractory variceal bleeding CTPV.Patients caused by CTPV were selected from database...
The effect of transjugular intrahepatic portosystemic shunt (TIPS) plus variceal embolization for treating gastric varices (GVs) remains controversial. This nationwide multicenter cohort study aimed to evaluate whether adding a small diameter (8-mm) TIPS could reduce the rebleeding incidence in patients with different types GVs. retrospective involved 629 who underwent 8-mm at 7 medical centers. primary endpoint was all-cause rebleeding, and secondary endpoints included overt hepatic...
Epirubicin has been widely used for chemotherapeutic treatment of gastric cancer; however, intrinsic and acquired chemoresistance remains an obstacle to successful management. The mechanisms underlying epirubicin resistance are still not well defined. Here we report the construction application a partially randomized retrovirus library 4 × 106 small interfering RNAs identify novel genes whose suppression confers in cancer cells SGC7901. From 12 resistant cell colonies, two targeting GAS1...
Purpose To assess the effects of preexisting nonmalignant portal vein thrombosis (PVT) on mortality, clinical relapse, shunt dysfunction, and overt hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic (TIPS) placement. Materials Methods This retrospective study was approved by institutional ethics committee, written informed consent obtained from all patients. From March 2001 to December 2014, 1171 consecutive patients with cirrhosis (762 men, 409 women; mean age, 50.0...
Abstract Background The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) for preventing rebleeding mostly comes from observations uncovered stents era. Moreover, association between Child–Pugh classes and post-TIPS hepatic encephalopathy (HE) has indicated that tolerance of PPG reduction depends on liver function. This study aimed to investigate the optimal covered TIPS explore threshold tailored find individualized balance...
Gastric cancer (GC) is the second leading cause of deaths around world. Chemoresistance an important reason for poor prognosis GC. Saikosaponin D (SSD) a natural constituent from Radix Bupleuri and exhibits various activities including antitumors. This study investigated effects mechanisms SSD on cisplatin (cis-diamminedichloroplatinum, DDP) sensitivity GC cells. Findings suggested that could promote inhibitory effect DDP proliferation invasion increase DDP-induced apoptosis in SGC-7901...
Objectives The efficacy of transjugular intrahepatic portosystemic shunt (TIPS) plus extrahepatic collateral embolisation (TIPS+E) in reducing rebleeding and hepatic encephalopathy (HE) post-TIPS was recently reported a meta-analysis, but further validation is essential. This study aims to confirm the effectiveness TIPS+E using real-world data. Methods multicentre retrospective cohort included 2077 patients with cirrhosis who underwent TIPS±E (TIPS: 631, TIPS+E: 1446) between January 2010...
Telomeres are the end structures of linear chromosomes in eukaryotic cells. The integrity a telomere is essential for overall stability chromosome. human protection telomeres 1 (hPOT1) protein, single-stranded telomeric DNA binding plays an important role and length regulation. Here, we show that loss hPOT1 by RNA interference BGC823 (poorly differentiated gastric adenocarcinoma) cells leads to increase multinucleated giant cells, decrease cell proliferation colony formation, induction...