A5049278307- Migration, Ethnicity, and Economy
- Migration, Identity, and Health
- China's Global Influence and Migration
- Multiculturalism, Politics, Migration, Gender
- Migration and Labor Dynamics
- Healthcare Systems and Practices
- Health, Medicine and Society
- French Urban and Social Studies
- Chinese history and philosophy
- Education, sociology, and vocational training
- Diaspora, migration, transnational identity
- Political and Social Issues
- Linguistic and Sociocultural Studies
- Social Policies and Family
- Aging, Elder Care, and Social Issues
- Migration and Exile Studies
- Global Public Health Policies and Epidemiology
- Social Sciences and Governance
- Psychoanalysis and Psychopathology Research
- Human Rights and Development
- COVID-19 Pandemic Impacts
- Adipose Tissue and Metabolism
- Employment and Welfare Studies
- Tracheal and airway disorders
- Cancer-related gene regulation
Shandong Provincial Hospital
2021-2025
Shandong University
2022-2025
Centre National de la Recherche Scientifique
2015-2024
Centre de Recherche Médecine, Sciences, Santé, Santé Mentale, Société
2015-2024
Ruian People's Hospital
2023-2024
Fujian University of Traditional Chinese Medicine
2024
Beijing University of Technology
2017-2024
Ministry of Education of the People's Republic of China
2024
Beijing Municipal Ecology and Environment Bureau
2024
China Medical University
2020-2024
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step of triglyceride (TG) synthesis. DGAT2 deletion in mice lowers liver TGs, and inhibitors are under investigation for treatment fatty disease. Here, we show that inhibition also suppressed SREBP-1 cleavage, reduced acid synthesis, lowered TG accumulation secretion from liver. increased phosphatidylethanolamine (PE) levels endoplasmic reticulum (ER) inhibited while overexpression ER PE concentrations cleavage vivo. enrichment...
This article focuses on the discrimination and racism experienced by Chinese migrants their descendants during Covid-19 pandemic. It analyses this group's increasing awareness activism toward racial in French society. The paper is based an empirical investigation using qualitative quantitative research methods (online surveys interviews) with people of origin living France. In addition, data from news media activists also crucial to study because important role they play social construction...
Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters and plays key role in B-cell development. Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx ions (Zn
Podocyte inflammatory injury has been indicated to play a pivotal role in the occurrence and development of diabetic nephropathy (DN). However, pathogenesis inflammation remains unclear. Recent researches have shown that GDF-15, member transforming growth factor-β superfamily, were elevated under pathological conditions, such as myocardial ischemia, cancer, well inflammation. Here, we demonstrated GDF-15 could alleviate podocyte by modulating NF-κB pathway. other pro-inflammatory factors,...
Many intracellular proteins are reversibly modified by O-linked GlcNAc (O-GlcNAc), a post-translational modification that dynamically regulates fundamental cellular processes in response to diverse environmental cues. Accumulating evidence indicates both excess and deficiency of protein O-GlcNAcylation can have deleterious effects on the cell, suggesting maintenance O-GlcNAc homeostasis is essential for proper function. However, mechanisms through which maintained physiologic state altered...
Abstract Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–protein interactions (PPIs), has been hampered by their inefficacious cellular internalization in diseased tissue. Therapeutic peptides engineered into nanostructures with stable spatial architectures and smart disease ability may provide a viable strategy to overcome the pharmaceutical obstacles peptides. This study describes assemble peptide–Au nanohybrid, followed further...
Abstract Excessive visceral fat accumulation is a primary risk factor for metabolically unhealthy obesity and related diseases. The highly susceptible to the availability of external nutrients. Nutrient flux into hexosamine biosynthetic pathway leads protein posttranslational modification by O -linked β-N-acetylglucosamine ( -GlcNAc) moieties. -GlcNAc transferase (OGT) responsible addition GlcNAc moieties target proteins. Here, we report that inducible deletion adipose OGT causes rapid loss...
Significance Overnutrition leads to metabolic disorders including obesity and diabetes. Studies have shown that enhanced inflammation is an essential player in the progression of diseases. However, how immune cells sense nutritional status contribute whole-body metabolism are largely unknown. Protein O -linked β- N -acetylglucosamine ( -GlcNAc) modification thought be a sensor modulates cell signaling. Here, we show overnutrition stimulates -GlcNAc signaling macrophages. suppresses...
Through specific structural modification of a 4-phenylindoline precursor, new 4-arylindolines containing thiazole moiety were developed and found to be promising modulators the programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis. Compound A30 exhibited outstanding biochemical activity, with an IC50 11.2 nM in homogeneous time-resolved fluorescence assay. In cell-based assay, significantly promoted IFN-γ secretion rescued T-cell proliferation, which inhibited by PD-1...
Aberrant upregulation of POU2F2 expression has been discovered in metastatic gastric cancer (GC). However, the mechanisms underlying aberrant and potential functions remain uncertain.The role mechanism GC metastasis were investigated epithelial cells, cell lines an experimental animal model by gain function loss function. Upstream downstream targets selected bioinformatics identified luciferase reporter assay, electrophoretic mobility shift assay chromatin immunoprecipitation PCR. The...
Palatable foods (fat and sweet) induce hyperphagia, facilitate the development of obesity. Whether how overnutrition increases appetite through adipose-to-brain axis is unclear. O-linked beta-D-N-acetylglucosamine (O-GlcNAc) transferase (OGT) couples nutrient cues to O-GlcNAcylation intracellular proteins at serine/threonine residues. Chronic dysregulation O-GlcNAc signaling contributes metabolic diseases. Here we show that adipocyte OGT essential for high fat diet-induced but dispensable...
The peptide-derived self-assembly platform has attracted increasing attention for its great potential to develop into multitargeting nanomedicines as well inherent biocompatibility and biodegradability. However, their clinical application potentials are often compromised by low stability, weak membrane penetrating ability, limited functions. Herein, inspired a natural protein from the seeds of Luffa cylindrica, we engineered via epitope grafting structure design hybrid peptide-based...
Abstract Late Paleozoic large-scale transcurrent tectonics and synkinematic intrusions are prominent features in the Eastern Tianshan segment of southwestern Central Asian Orogenic Belt. However, spatial temporal relationship between crustal-scale shear zones remains unclear. Here we report petrology, geochemistry, geochronology Qiziltag pluton associated with Kanggur-Huangshan Shear Zone (KHSZ) a view to characterize shearing. Field relations zircon U-Pb ages indicate that was formed...
Small nucleolar RNA SNORD50A and SNORD50B (SNORD50A/B) has been reported to be recurrently deleted function as a putative tumor suppressor in different types of cancer by binding suppressing the activity KRAS oncoproteins. Its deletion correlates with poorer patient survival. However, this study, we surprisingly found that SNORD50A/B loss predicted better survival breast patients carrying wild-type p53. Functional studies showed strongly inhibited proliferation, migration, invasion...
Vegetation is a critical component of ecosystems that influenced by climate change and human activities. It therefore great importance to investigate trends in vegetation dynamics explore how these are This will help formulate effective ecological restoration policies ensure sustainable development. As the Normalized Difference Index (NDVI) strongly correlated with may be used as proxy measure for condition, spatiotemporal characteristics NDVI derived from SPOT/VEGETATION data China over...
Owing to the coronavirus disease 2019, medical learning burnout has attracted increasing attention in educational research. It a serious negative impact on students and their service quality. This could impair professional development of students; weaken personal quality; lead problems such as increased errors reduced patient care quality satisfaction. study aimed examine effects perceived stress, social support, Big Five personality traits among students.
Abstract Diabetic nephropathy (DN), one of the more prevalent microvascular complications in patients diagnosed with diabetes mellitus, is attributed as main cause end-stage renal disease (ESRD). Lipotoxicity podocytes caused by hyperglycemia has been recognised a significant pathology change, resulting deterioration glomerular filtration barrier. Research demonstrated how dapagliflozin, kind SGLT2i, exhibits multifaceted and powerful protective effect DN, entirely independent hypoglycemic...