A5029865323- Melanoma and MAPK Pathways
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- PI3K/AKT/mTOR signaling in cancer
- Nanoparticle-Based Drug Delivery
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Intraocular Surgery and Lenses
- Escherichia coli research studies
- Synthesis and properties of polymers
- RNA and protein synthesis mechanisms
- Graphene and Nanomaterials Applications
- Ubiquitin and proteasome pathways
- Peptidase Inhibition and Analysis
- Flame retardant materials and properties
- Connexins and lens biology
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Synthesis and biological activity
- Anorectal Disease Treatments and Outcomes
- Protein Degradation and Inhibitors
Xi'an Jiaotong University
2015-2024
Institute of Science and Technology
2024
Frontier Science Foundation
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
China XD Group (China)
2015-2020
Center for Translational Molecular Medicine
2019
Wuhan No. 7 Hospital
2018-2019
Ministry of Education of the People's Republic of China
2015
Thomas Jefferson University
2009-2013
Abstract The first step of bacteriophage (phage) infection is the attachment phage virion onto a susceptible host cell. This adsorption process usually described by mass-action kinetics, which implicitly assume an equal influence density and rate on process. Therefore, environment with high can be considered as equivalent to endowed rate, vice versa. On basis this assumption, effect evolution optimal lysis time reinterpreted from previous optimality models time. That is, strains higher would...
Melanoma cells are highly resistant to anoikis, a form of apoptosis induced in nonadherent/inappropriate adhesion conditions. Depleting B-RAF or the prosurvival Bcl-2 family protein Mcl-1 renders mutant melanoma susceptible anoikis. In this study, we examined effect targeting on survival primary stage cultured three-dimensional type I collagen gels, which partially mimics dermal microenvironment. Depletion/inhibition with small interfering RNA inhibitor, PLX4720, collagen. Apoptosis was...
Developing a sophisticated nanomedicine platform to deliver therapeutics effectively and safely into tumor/cancer cells remains challenging in the field of nanomedicine. In particular, reliable peptide drug delivery systems capable overcoming biological barriers are still lacking. Here, we developed simple, rapid, robust strategy manufacture nanoclusters ∼90 nm diameter that self-assembled from lanthanide-doped nanoparticles (5 nm), two anticancer peptides with different targets (BIM PMI),...
Nanocarrier surface chemistry plays a vital role in mediating cell internalization and enhancing delivery efficiency during vivo chemotherapy. Inspired by the ability of proteins to alter their conformation mediate functions, pH‐/thermal‐/glutathione‐responsive polymer zipper consisting cell‐penetrating poly(disulfide)s thermosensitive polymers bearing guanidinium/phosphate (Gu + /pY − ) motifs spatiotemporally tune composition nanocarriers for precise tumor targeting efficient drug is...
Multifunctional nanodrugs with the integration of precise diagnostic and effective therapeutic functions have shown great promise in improving efficacy cancer therapy.
Abstract Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–protein interactions (PPIs), has been hampered by their inefficacious cellular internalization in diseased tissue. Therapeutic peptides engineered into nanostructures with stable spatial architectures and smart disease ability may provide a viable strategy to overcome the pharmaceutical obstacles peptides. This study describes assemble peptide–Au nanohybrid, followed further...
In human mutant BRAF melanoma cells, the stemness transcription factor FOXD3 is rapidly induced by inhibition of ERK1/2 signaling and mediates adaptive resistance to RAF inhibitors. However, mechanism underlying ERK control expression remains unknown. Here we show that SOX10 both necessary sufficient for inhibitor-induced in cells. activates binding a regulatory element promoter. Phosphorylation inhibits its activity toward multiple target genes interfering with sumoylation at K55, which...
ERK1/2 signaling is frequently dysregulated in tumors through BRAF mutation. Targeting mutant with vemurafenib elicits therapeutic responses; however, durable effects are often limited by pathway reactivation via poorly defined mechanisms. We generated BRAF(V600E) melanoma cells that exhibit resistance to PLX4720, the tool compound for vemurafenib, co-expressed (Q61K) NRAS. In these BRAF(V600E)/NRAS(Q61K) co-expressing cells, re-activation of during PLX4720 treatment was dependent on...
The abnormal aggregation of α-synuclein (α-Syn) is closely associated with Parkinson's disease. Different post-translational modifications α-Syn have been identified and contribute distinctly in cytotoxicity. Recently, was reported to be N-terminally acetylated cells, yet the functional implication this modification, especially oligomerization, remains unclear. By using a solid-state nanopore system, we found that N-terminal acetylation can significantly decrease oligomerization....
We developed a bifunctional nanoplatform for targeted synergistic chemo–photothermal cancer treatment. The was constructed through facile method in which poly(N-vinyl pyrrole) (PVPy) coated on cut multiwalled carbon nanotubes (c-MWNTs); FA-PEG-SH then linked by thiol–ene click reaction to improve the active targeting ability, water dispersibility, and biocompatibility extend circulation time blood. PVPy shell not only enhanced photothermal effect of c-MWNTs significantly but also provided...
The peptide-derived self-assembly platform has attracted increasing attention for its great potential to develop into multitargeting nanomedicines as well inherent biocompatibility and biodegradability. However, their clinical application potentials are often compromised by low stability, weak membrane penetrating ability, limited functions. Herein, inspired a natural protein from the seeds of Luffa cylindrica, we engineered via epitope grafting structure design hybrid peptide-based...
Bacterial biofilm is ubiquitous in nature. However, it not clear how this crowded habitat would impact the evolution of bacteriophage (phage) life history traits. In study, we constructed isogenic lambda phage strains that only differed their adsorption rates, because presence/absence extra side tail fibers or improved fiber J, and maker states. The high cell density viscosity environment was approximated by standard double-layer agar plate. infection cycle decomposed into three stages:...
Although previous evidence indicates close involvement of CD147 in the pathogenesis liver fibrosis, underlying molecular mechanisms and its therapeutic value remain largely unknown. In present study, we investigated biological roles fibrosis assessed as a target molecule CCl4-induced mouse model. We found that was highly expressed both hepatocytes SECs (sinusoidal endothelial cells) fibrotic tissues. Additionally, it significantly associated with stage. TGF-β1 (transforming growth factor β1)...
Abstract Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis complex and has not been fully understood. C10orf99 was recently identified human antimicrobial peptide whose mRNA expression elevated in psoriatic samples. In this study, we investigated the functional roles epidermal proliferation under condition. We showed that protein significantly up-regulated samples from patients ortholog gene levels were imiquimod (IMQ)-induced psoriasis-like lesions...
// Dan Xu 1, * , Bing Zhang Chongbing Liao 2 Wei 1 Weijia Wang Ying Chang Yongping Shao Key Laboratory of Biomedical Information Engineering the Ministry Education, Department Biological Science and Engineering, School Life Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Center for Translational Medicine, Frontier Institute Xi'an Xi'an, These authors have contributed equally to this work Correspondence to: Shao, email: yongping.shao@xjtu.edu.cn Keywords: human...