A5100452051- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Seaweed-derived Bioactive Compounds
- Immune cells in cancer
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Echinoderm biology and ecology
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Pharmacological Effects of Natural Compounds
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Macrophage Migration Inhibitory Factor
- HIV Research and Treatment
- Chemokine receptors and signaling
- Colorectal Cancer Surgical Treatments
- NF-κB Signaling Pathways
- vaccines and immunoinformatics approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2025
Zhejiang University
2024
Sir Run Run Shaw Hospital
2024
Shanghai Public Health Clinical Center
2014-2024
Hangzhou Medical College
2020-2024
Zhejiang Provincial People's Hospital
2020-2024
Wake Forest University
2020-2024
Shenzhen University Health Science Center
2024
National Cancer Institute
2023
Changhai Hospital
2023
Abstract The molecular basis underlying the particularly aggressive nature of pancreatic ductal adenocarcinoma (PDAC) still remains unclear. Here we report evidence that insulin-like growth factor–binding protein IGFBP2 acts as a potent oncogene to drive its extremely malignant character. We found elevated expression in primary tumors was associated with lymph node metastasis and shorter survival patients PDAC. Enforced promoted invasion PDAC cells vitro vivo by inducing NF-κB–dependent...
Abstract Induction of antigen-specific immune activation by the maturation dendritic cells (DCs) is a strategy used for cancer immunotherapy. In this study, we find that FimH, which an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC in mice vivo. A combined treatment regimen with FimH antigen promotes activation, including proliferation T cells, production IFN-γ TNF-α, infiltration effector into tumors,...
Most cancer-related deaths are due to metastasis or recurrence. Therefore, the ultimate goal of cancer therapy will be treat metastatic and recurrent cancers. Combination for one trial effective treating In this study, Escherichia coli-mimetic nanomaterials synthesized using coli membrane proteins, adhesion gold nanorods, which named E. mimetic AuNRs (ECA), combination against its ECA treatment with 808 nm laser irradiation eliminates CT-26 4T1 tumors via a photothermal effect. induces...
Asthma is characterized by airway inflammation and mucus hypersecretion. Curcumin possessed a potent anti-inflammatory property involved in the PPARγ-dependent NF-κB signaling pathway. Then, aim of current study was to explore value curcumin asthmatic secretion its underlying mechanism. In vivo, mice were sensitized challenged ovalbumin (OVA) induce chronic asthma. Airway analyzed. vitro, BEAS-2B cells obtained. MCP-1, MUC5AC, PPARγ expression phosphorylation p65 DNA-binding activity...
ABSTRACT Staphylococcus aureus bloodstream infection (bacteremia) is a major cause of morbidity and mortality places substantial cost burdens on health care systems. The role peripheral blood dendritic cells (PBDCs) in the immune responses against S. has not been well characterized. In this study, we demonstrated that BDCA1 + myeloid DCs (mDCs) represent unique PBDC subset can induce infection. mDCs could engulf strongly upregulated expression costimulatory molecules production...
Our previous study demonstrated that ascophyllan, a sulfated polysaccharide purified from brown alga, has immune-activating effects. In this study, we evaluated ascophyllan as an adjuvant for its therapeutic and preventive effect on tumor in mouse melanoma model. Ascophyllan induced migration of DCs to spleen tumor-draining lymph node (drLN) B16 Moreover, activation dendritic cells (DCs), promoted IFN-γ- TNF-α-producing Th1 immune responses tumor-bearing mice. addition, treatment with...
// Dan Xu 1, * , Bing Zhang Chongbing Liao 2 Wei 1 Weijia Wang Ying Chang Yongping Shao Key Laboratory of Biomedical Information Engineering the Ministry Education, Department Biological Science and Engineering, School Life Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China Center for Translational Medicine, Frontier Institute Xi'an Xi'an, These authors have contributed equally to this work Correspondence to: Shao, email: yongping.shao@xjtu.edu.cn Keywords: human...
Sepsis is an infection- or toxin-mediated systemic inflammatory syndrome. Previous studies have shown that melatonin, the primary hormone produced by pineal gland, attenuates effect ofpolymicrobial infection-mediated septic shock in animals. However, mechanism of anti-septic melatonin during polymicrobial infection has not been well studied. In this study, we investigated how protects mice from sepsis. Melatonin treatment inhibited peripheral tissue inflammation and damage a cecal ligation...
Natural polysaccharides exhibit beneficial immune modulatory effects, including stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, its tumor-bearing mice. Intravenous CFP treatment C57BL/6 mice resulted in upregulation CD69, which is a marker associated with NK activation. addition, intracellular levels interferon (IFN)-γ cytotoxic mediators perforin granzyme B were markedly increased...
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on induction anti-cancer immunity in lung was examined by administration. C57BL/6 and BALB/c mice, ECF promoted activation dendritic cells (DCs), natural killer (NK) cells, T mediastinal lymph node (mLN). The ECF-induced...
Antigen accumulation in lymph nodes (LNs) is critical for vaccine efficacy, but understanding of biodistribution humans or large animals remains limited. Using the rhesus macaque model, we employed a combination positron emission tomography (PET) and fluorescence imaging to characterize whole-animal tissue-level subunit comprised an HIV envelope trimer protein nanoparticle (trimer-NP) lipid-conjugated CpG adjuvant (amph-CpG). Following immunization thigh, PET revealed uptake primarily...
Ginseng extract has been shown to possess certain anti-virus, anti-tumor and immune-activating effects. However, the immunostimulatory effect of ginseng berry (GB) less well characterized. In this study, we investigated GB on activation mouse dendritic cells (DCs) in vitro vivo. treatment induced up-regulation co-stimulatory molecules bone marrow-derived DCs (BMDCs). Interestingly, a higher degree molecule than root (GR) at same concentrations. Moreover, vivo administration promoted CD86,...
// Bian Jang 1, 2, 3, 4, * , Li Xu Madhappan S. Moorthy 2 Wei Zhang 1 Ling Zeng Mingyeong Kang 5 Minseok Kwak Junghwan Oh 4 and Jun-O Jin Shanghai Public Health Clinical Center, Medical College, Fudan University, Shanghai, China Marine-Integrated Bionics Research Pukyong National Busan, South Korea 3 Department of Biomedical Engineering Center for Technology (BK21 Plus), Interdisciplinary Program Mechanical & Electrical Engineering, Chemistry, These authors have contributed equally to this...
<ns4:p>Dendritic cells (DCs) play an essential role in the induction of adaptive immune responses against infectious agents and generation tolerance to self-antigens. In this mini-review, we summarize new evidence suggesting that tissue residence significantly shapes last developmental steps DCs into locally adapted cellular entities, enabling them perform tissue-specific tasks while maintaining core DC properties. We also discuss recent advances have highlighted DCs’ rather complex...
Background Advanced cancer therapy is targeted at primary tumors and also recurrent or metastatic cancers. Combinational treatment has recently shown high efficiency against In this study, we synthesized a thermal responsive hybrid nanoparticle (TRH) containing FimH, an immune stimulatory recombinant protein, for the induction of combination photothermal (PTT) immunotherapy its metastasis. Methods The was incorporated with near-infrared (NIR) absorbent, indocyanine green, decorated FimH on...
Abstract Anticancer drug‐mediated induction of immunogenic cell death (ICD) blocks metastasis or recurrence in cancer cells by promoting specific immune activity against antigens. However, this strategy has failed to afford adequate treatment efficiency. Overcoming the failure ICD‐mediated therapy, lipid nanoparticles (LNPs) containing surface proteins are synthesized using sonication and extrusion without microfluidics. In addition, these LNPs decorated with high‐mobility group box 1...
Previous studies have demonstrated that pullulan, a polysaccharide purified from Aureobasidium pullulans, has immune-stimulatory effects on T and B cells. Moreover, pullulan been used as carrier in the delivery of antigen (Ag) peptide to lymphoid tissues. However, vivo effect dendritic cells (DC) not well characterized. In this study, we assessed DC activation anti-cancer immunity. The results showed treatment up-regulated co-stimulatory molecule expression enhanced pro-inflammatory cytokine...
In recent years, several studies have shown that Rhodiola rosea can enhance cellular immunity and humoral immune function in mice, thus, it has become a research hotspot. However, its underlying mechanism of action remained elusive. The present study investigated whether was able to downregulate the expression tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2), thereby inhibiting apoptotic genes, attenuating T‑lymphocyte apoptosis improving septic mice. A mouse model caecal ligation...
This study investigates the in vivo functions of ginseng berry extract (GB) as a therapy for dextran sodium sulfate (DSS)-induced colitis. C57BL/6 mice were given drinking water containing DSS (3%) eight days to induce acute At same time, received an oral dose GB (50 mg/kg) once daily. The GB-treated less susceptible development colitis than control treated with saline, determined by weight loss, disease activity, and colon histology. administration DSS-treated also reduced numbers inhibited...