A5101411691- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Inflammation biomarkers and pathways
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Nanoparticles: synthesis and applications
- Andrographolide Research and Applications
- Neuroscience of respiration and sleep
- Natural Compounds in Disease Treatment
- Material Science and Thermodynamics
- Anesthesia and Neurotoxicity Research
- Environmental Science and Water Management
- Graphene and Nanomaterials Applications
- Respiratory viral infections research
- Pigment Synthesis and Properties
- Inflammasome and immune disorders
- Fungal Infections and Studies
- Advanced Nanomaterials in Catalysis
- Nail Diseases and Treatments
- PARP inhibition in cancer therapy
- Antifungal resistance and susceptibility
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- NF-κB Signaling Pathways
Second Military Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2008-2019
Chongqing Medical University
2008-2019
Dalian Medical University
2008-2019
Background Nuclear factor-κB (NF-κB) is a central transcriptional factor and pleiotropic regulator of many genes involved in acute lung injury. Andrographolide found the plant Andrographis paniculata widely used Traditional Chinese Medicine, exhibiting potently anti-inflammatory property by inhibiting NF-κB activity. The purpose our investigation was designed to reveal effect andrographolide on various aspects LPS induced inflammation vivo vitro. Methods Results In vivo, BALB/C mice were...
Asthma is characterized by airway inflammation and mucus hypersecretion. Curcumin possessed a potent anti-inflammatory property involved in the PPARγ-dependent NF-κB signaling pathway. Then, aim of current study was to explore value curcumin asthmatic secretion its underlying mechanism. In vivo, mice were sensitized challenged ovalbumin (OVA) induce chronic asthma. Airway analyzed. vitro, BEAS-2B cells obtained. MCP-1, MUC5AC, PPARγ expression phosphorylation p65 DNA-binding activity...
The reduction of pulmonary surfactant (PS) is essential for decreased compliance and edema in acute lung injury (ALI). Thyroid transcription factor-1 (TTF-1) plays a major role the regulation protein-A (SP-A), most abundant protein component PS. Simultaneously, glucagon-like peptide-1 (GLP-1) analogue can enhance SP-A expression lung. However, underlying mechanism still unknown. purpose this study was to explore whether liraglutide, GLP-1 analogue, upregulates through TTF-1 signaling pathway...
Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme in salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis. Thus far, hepatic Nampt has not been extensively explored terms its effects on serum lipid stability and liver lipids metabolism. In this study, hepatocyte-specific knockout (HC-Nampt-/-) mice were generated by Cre/loxP system. mRNA expression was reduced liver, but other tissues, HC-Nampt-/- compared with wild-type (WT) mice. Hepatic...
T helper cell 17 (Th17), one type of CD4+ cell, plays an important role in regulating the acute lung injury (ALI) inflammatory response. Recent studies showed that Wnt/β-catenin pathway could modulate differentiation and function cell. However, whether regulate Th17 development progress ALI induced by lipopolysaccharide (LPS) is still unknown. To test this, we used dickkopf1 (Dkk-1) to block LiCl activate instillation murine model ALI. Our results revealed activation significantly aggravated...
The objective of the study is to explore role respiratory syncytial virus Toll-like receptor 3 (TLR3)-mediated immune response in pathogenesis acute exacerbations chronic obstructive pulmonary disease (AECOPD). A total 20 AECOPD patients and 10 normal volunteers were studied. TLR3 was detected by RT-PCR, (RSV) nested RT-PCR. Then, A549 cells infected RSV at different time points viral titers. mRNA protein interferon regulatory factor (IRF3) western blot, IRF3 localization immunofluorescence....
Serum cryptococcal antigen (CrAg) test is the most used noninvasive method to detect infection. However, false-negative CrAg not uncommon in clinical practice. Then, aim of this study was investigate factors associated with among non-human immunodeficiency virus (HIV) adult patients pulmonary cryptococcosis and its features.One hundred fourteen non-HIV cryptococcosis, proven by biopsy, were retrospectively reviewed. Finally, 85 enrolled; 56 positive (CrAg+ group) 29 negative (CrAg- group)....
Treatment non-adherence is a challenge to achieve asthma control. However, few prospective studies were done for exploring patient adherence in real world.To evaluate treatment and causes of large Chinese population. To analyze newly-diagnosed patients' first time.About 1582 data collected from 12 study centers China February, 2012 October, 2012. Disease information subjects at clinic visit, 4, 12, 24 weeks after that, follow-up phone calls carried out recording subjects' based on their...
In clinic, exposed to the same risk factors that induce acute lung injury(ALI), only a minority of patients develop respiratory distress syndrome. Different have ditrferent prognosis. It is recognized gene polymorphism plays critical role in susceptivity All and The paper summarizes different polymorphisms patients' susceptibility prognosis. Key words: Acute injury; Angiotensin-converting enzymeSurfactant protein-B; Heat shock protein 70; Gene