A5042471205- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Supramolecular Self-Assembly in Materials
- Catalytic C–H Functionalization Methods
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Silk-based biomaterials and applications
- Advanced Polymer Synthesis and Characterization
- T-cell and B-cell Immunology
- Advanced Materials and Mechanics
- Liquid Crystal Research Advancements
- Graphene and Nanomaterials Applications
- Sulfur-Based Synthesis Techniques
- biodegradable polymer synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Phosphorus and nutrient management
- Advanced Battery Materials and Technologies
- Cryospheric studies and observations
- Flexible and Reconfigurable Manufacturing Systems
- X-ray Diffraction in Crystallography
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
China Agricultural University
2025
Nanjing University of Chinese Medicine
2023-2024
Sun Yat-sen University
2013-2024
China University of Mining and Technology
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2018-2023
Daping Hospital
1997-2023
Army Medical University
1997-2023
Huazhong University of Science and Technology
2006-2022
Hunan Children's Hospital
2010-2022
Union Hospital
2022
Expression of chirality in the highly ordered assembly structures various types natural and synthetic materials is still a mystery. Although surface stresses have been known to widely exist polymer lamellae, how they affect twisting yet an unsolved issue. Here we report inversion lamellar microbial poly(R-3-hydroxybutyrate) copolymers from left-handed right-handed via copolymerization or blending, with molecular crystalline core unchanged. We interpret observed complicated curvature...
Here, kartogenin (KGN), an emerging stable nonprotein compound with the ability to promote differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes, was grafted onto surface modified ultrasmall superparamagnetic iron-oxide (USPIO) and then integrated cellulose nanocrystal/dextran hydrogels. The hydrogels served as a carrier for USPIO-KGN matrix cartilage repair. We carried out in vitro vivo studies, results which demonstrated that KGN undergoes long-term...
Asthma is characterized by airway inflammation and mucus hypersecretion. Curcumin possessed a potent anti-inflammatory property involved in the PPARγ-dependent NF-κB signaling pathway. Then, aim of current study was to explore value curcumin asthmatic secretion its underlying mechanism. In vivo, mice were sensitized challenged ovalbumin (OVA) induce chronic asthma. Airway analyzed. vitro, BEAS-2B cells obtained. MCP-1, MUC5AC, PPARγ expression phosphorylation p65 DNA-binding activity...
Abstract To treat bone defects, repairing the nerve‐rich periosteum is critical for local electric field. In this study, an endogenous field coupled with 2D black phosphorus electroactive to explore its role in promoting regeneration through nerves. Scanning electron microscopy (SEM) and transmission (TEM) are used characterize electrically active biomimetic periosteum. Here, vitro effects exerted by on transformation of Schwann cells into repair phenotype, axon initial segment (AIS) dense...
To solve the contradiction between stability and activity of catalytic membrane achieve process intensification during reaction, a novel porous Fe-polyacrylonitrile (PAN) was synthesized by one-step cryogenic auxiliary electrospinning method tested for wet peroxide oxidation (CWPO). During synthesis, nanometals can be evenly entrapped in PAN fiber fibrous structure formed simultaneously. Fe-PAN showed extraordinary excellent strongly strengthened reaction due to reduced diffusion resistance...
Graphene oxide (GO), derived from the two-dimensional nanosheet graphene, has received unprecedented attention in field of metal corrosion protection owing to its excellent barrier performance and various active functional groups. In this review, mechanism “labyrinth effect” composite coatings against was demonstrated systematically. The origination, structure properties GO were also analyzed. Their poor dispersion polymer tendency aggregate as nanofillers are main limitations during...
Articular cartilage repair remains a clinical and scientific challenge with increasing interest focused on the combined techniques of gene transfer tissue engineering. Transforming growth factor beta 1 (TGF-beta(1)) is multifunctional molecule that plays central role in promotion repair, inhibition inflammatory alloreactive immune response. Cell mediated therapy can allow sustained expression TGF-beta(1) may circumvent difficulties associated delivery. The objective this study was to...
Large segmental bone defect repair remains a clinical and scientific challenge with increasing interest focused on combining gene transfer tissue engineering techniques. Basic fibroblast growth factor (bFGF) is one of the most prominent osteogenic factors that has potential to accelerate healing by promoting proliferation differentiation mesenchymal stem cells (MSCs) regeneration capillary vasculature. However, short biological half-lives may impose severe restraints their usefulness....
In this study, PLLA nanofibers are fabricated by electrospinning and their surfaces modified laminin/chitosan (LN/CS) polyelectrolyte multilayer. Surface C/N ratio determined XPS analysis quantitatively indicates of discrete coating layers on the nanofibers. The amount LN deposited sustainably increases with LbL assembly processing, approximately 60 ng mm −2 per cycle LN/CS deposition. LN‐modified scaffolds significantly induce neurite outgrowth DRG neurons NSC compared to pure nanofibrous...
Neural stem cells (NSCs) have emerged as a potential source for cell replacement therapy following spinal cord injury (SCI). However, poor survival and low neuronal differentiation remain major obstacles to the use of NSCs. Biomaterials with neurotrophic factors are promising strategies promoting proliferation Silk fibroin (SF) matrices were demonstrated successfully deliver growth preserve their potency. In this study, by incorporating NT-3 into SF coating, we developed NT-3-immobilized...
Visible-light-induced 1,6-enyne-triggered C-Br bond homolysis of bromomalonates has been developed. This transition-metal-free, photocatalyst-free, and oxidant- additive-free protocol affords an efficient approach for divergent synthesis carbonylated hydroxylated benzofurans from 1,6-enynes under mild conditions. Significantly, mechanistic studies reveal that the bonds appears to experience energy-transfer pathway, atom-transfer radical addition products are key intermediates generate benzofurans.
Background: Obesity is characterized by increased adipose tissue mass that results from fat cell size (hypertrophy) and number (hyperplasia). The molecular mechanisms govern the regulation differentiation of adipocytes play a critical role for better understanding pathological mechanism obesity. However, adipocyte still unclear. Objective: present study aims to compare gene expression changes during in transcriptomic level, which may help understand differentiation. Methods: RNA sequencing...
Abstract Mountain runoff is a vital water source for irrigation in global arid regions. Investigating the roles of major mountain components such as snowmelt and glacier‐melt, on downstream availability important understanding resource security. Snowmelt glacier‐melt have different timing availability. However, their potentially distinct impacts supplies been seldom investigated previously. This study proposes novel indicator, Irrigation Dependence Component ( IDC ), to assess individual...
Obesity is a chronic and complex disease caused by excessive fat deposition, which can lead to multiple complications. It affects individuals of all ages backgrounds, contributing growing public health crisis worldwide. In modern medicine, the available treatments for obesity include drugs, behavioral modifications, surgical procedures. However, their efficacy often unsatisfactory may be accompanied various side effects. contrast, Traditional Chinese Medicine offers wide range treatment...
A difluorocarbene-enabled regioselective C(sp3)-O bond cleavage of oxiranes has been developed. The protocol provides an efficient and practical approach to cyclic carbonates under mild conditions. Significantly, the generation difluorocarbene with BrCF2CO2Et/H2O serving as a CO2 equivalent metal-free conditions disclosed.