A5079970026- Metabolism and Genetic Disorders
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Crystallization and Solubility Studies
- Mitochondrial Function and Pathology
- X-ray Diffraction in Crystallography
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Thyroid Disorders and Treatments
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Neurofibromatosis and Schwannoma Cases
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Neonatal Health and Biochemistry
- DNA Repair Mechanisms
- Genomics and Rare Diseases
- Supramolecular Self-Assembly in Materials
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
First Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Children's Hospital of Zhejiang University
2003-2024
Nanjing University
2023
Collaborative Innovation Center of Advanced Microstructures
2023
Zhejiang University
2011-2018
Xi'an Jiaotong University
2013-2014
Zero to Three
2013
MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play critical role in tumorigenesis. Increasing evidences indicate miR-145 acts tumor suppressor numerous human cancers. However, its oral carcinogenesis remains poorly defined. The aim this study is to determine expression levels squamous cell carcinomas (OSCCs) and normal mucosa tissues, explore biological functions OSCCs.Reverse transcription quantitative real-time PCR (RT-qPCR) assay was used evaluate...
Abstract Clinical translation of therapeutic peptides, particularly those targeting intracellular protein–protein interactions (PPIs), has been hampered by their inefficacious cellular internalization in diseased tissue. Therapeutic peptides engineered into nanostructures with stable spatial architectures and smart disease ability may provide a viable strategy to overcome the pharmaceutical obstacles peptides. This study describes assemble peptide–Au nanohybrid, followed further...
Increasing evidences have implicated somatic gain-of-function mutations at the telomerase reverse transcriptase (TERT) promoter as one of major mechanisms that promote transcriptional activation TERT and subsequently maintain telomere length in human cancers including glioma. To investigate prognostic value these length, individually their coexistence, gliomas, we analyzed two C228T C250T promoter, relative (RTL), IDH1 mutation MGMT methylation 389 glioma patients, explored associations with...
Abstract The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. aim this study was to explore the role EHF tumorigenesis and its potential as a therapeutic target By using quantitative RT-PCR (qRT-PCR), immunohistochemistry (IHC) fluorescence situ hybridization (FISH) assays, we investigated expression copy number cohort control subjects. Specific siRNAs used determine biologic impacts...
The peptide-derived self-assembly platform has attracted increasing attention for its great potential to develop into multitargeting nanomedicines as well inherent biocompatibility and biodegradability. However, their clinical application potentials are often compromised by low stability, weak membrane penetrating ability, limited functions. Herein, inspired a natural protein from the seeds of Luffa cylindrica, we engineered via epitope grafting structure design hybrid peptide-based...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common X-linked enzymopathies caused by G6PD gene variant. We aimed to provide characteristics and variant distribution in a large Chinese newborn screening population. investigated prevalence China from 2013 2017. Then, we examined activity representative birth cohort explore 2016. then performed multicolor melting curve analysis classify variants 10,357 neonates with activity-confirmed deficiency, DNA Sanger sequencing...
Newborn screening (NBS) aims to detect congenital anomalies, and next-generation sequencing (NGS) has shown promise in this aspect. However, the NBS strategy for monogenic inherited diseases China remains insufficient. We developed a NeoEXOME panel comprising 601 genes that are relevant Chinese population found through extensive research on available databases. An interpretation system grade results into positive (high-risk, moderate-risk, low-risk genotypes), negative, carrier according...
Abstract Background Change of mitochondrial DNA (mtDNA) copy number is widely reported in various human cancers, including gastric cancer, and considered to be an important hallmark cancers. However, there remarkably little consensus on the value variable mtDNA content prognostic evaluation this cancer. Methods Using real-time quantitative PCR approach, we examined a cohort cancers normal tissues, explored association with clinical outcomes cancer patients. Results Our data showed that...
Peptide-tuned self-assembly of macromolecular agents (>500 Da) such as therapeutic peptides offers a strategy to improve the properties and biofunctions degradable nanomaterials, but tough requirement therapeutics delivery lack understanding peptide-based design present high barriers for their applications. Herein, we developed new nanoengineering drugs by an elaborate peptide, termed PSP (VVVVVHHRGDC), capable directly conjugating with cargo be PSP-cargo monomer building block tending...
BRAFV600E mutation is frequently found in human cancers particularly thyroid cancer and melanoma, involved the regulation of gene expression through activating MAPK/Erk signaling. Trimethylation histone 3 lysine 27 (H3K27me3) a critical epigenetic mark for maintenance silencing tumorigenesis. However, molecular mechanism underlying complex interplay between these two events remains to be explored. In present study, we conducted chromatin immunoprecipitation combined with next-generation...
Abstract HACE1, an E3 ubiquitin-protein ligase, is frequently inactivated and has been evidenced as a putative tumor suppressor in different types of cancer. However, its role glioma remains elusive. Here, we observed increased expression HACE1 gliomas related to control subjects, found strong correlation high with poor prognosis patients WHO grade III IV well low-grade (LGG) receiving radiotherapy. knockdown obviously suppressed malignant behaviors cells, while ectopic enhanced cell growth...
Lanthanide clusters with good stability and intriguing physical properties are attractive in many fields. By reacting 9-anthracenylphosphonic acid (AnPO3H2) lanthanide nitrates under solvothermal conditions, we obtained a series of hexanuclear phosphonate cages [H3O][Ln6(PO4)(AnPO3)8(DMF)6]·2DMF·H2O (Ln6, Ln = NdIII, EuIII, GdIII, DyIII, HoIII, ErIII, YbIII). Within the cluster, six atoms form an octahedron its eight faces covered by groups. The situ generated phosphate anion resides inside...
Alterations in mitochondrial DNA (mtDNA) copy number have been widely reported various human cancers, and considered to be an important hallmark of cancers. However, little is known about the value variations mtDNA prognostic evaluation laryngeal cancer. Using real-time quantitative PCR method, we investigated a cohort cancers (n =204) normal tissues =40), explored association variable with clinical outcomes cancer patients. Our data showed that relative mean content was higher patients...
Abstract Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker some subtypes glioma. In order to investigate biological role RTEL1 in Relative telomere length (RTL) and mRNA was explored regression analysis performed further examine relationship RTL expression with clinicopathological characteristics glioma patients. We observed that high is positively correlated tissue, serve a poor prognostic factor TERT wild-type...
Thyroid nodules with indeterminate cytological features on fine needle aspiration biopsy specimens (FNABs) have a ~20% risk of thyroid cancer. BRAF V600E mutation and DNA methylation are useful markers to distinguish malignant neoplasm from benign. The aim this study was determine whether combined detection FNABs could improve the diagnostic accuracy Using pyrosequencing quantitative methylation-specific PCR (Q-MSP) methods, 79 38 patients in training test groups, respectively, were analyzed...