A5100621115- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gut microbiota and health
- Circular RNAs in diseases
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Heat shock proteins research
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Receptor Mechanisms and Signaling
- Prostate Cancer Treatment and Research
- Endoplasmic Reticulum Stress and Disease
- Mycobacterium research and diagnosis
- Probiotics and Fermented Foods
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Hippo pathway signaling and YAP/TAZ
- Reproductive tract infections research
- Acute Myeloid Leukemia Research
- Hedgehog Signaling Pathway Studies
- Glutathione Transferases and Polymorphisms
Nanchang University
2020-2024
Chengdu University of Traditional Chinese Medicine
2024
Shaanxi University of Chinese Medicine
2024
Washington State University Spokane
2022-2024
First Affiliated Hospital of Zhengzhou University
2018-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2024
Guangzhou Medical University
2024
Third Affiliated Hospital of Guangzhou Medical University
2024
Sinovac Biotech
2024
Zhengzhou University
2023
Test anxiety is a common issue among college students, which can affect their physical and psychological health. However, effective interventions or therapeutic strategies are still lacking. This study aims to evaluate the potential effects of
The current study aims to evaluate the potential roles of taking probiotics postoperatively in attenuating gastrointestinal complications and disturbed gut microbiota colorectal cancer (CRC) patients undergoing chemotherapy. One hundred eligible CRC who were treated with radical surgery needed receive chemotherapy recruited. Half them randomly assigned Probio group take a probiotic combination from post-operation end first chemotherapeutic course. other half placebo instead classified as...
Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as pivotal process contributing to the pathology Alzheimer's Disease (AD). Glutathione Peroxidase 4 (GPX4), vital defense mechanism countering ferroptosis by nullifying lipid peroxides and maintaining redox equilibrium, garnered significant attention in AD. Thus, identifying inhibitors target GPX4 activation may help mitigate neuronal damage impede AD progression.
Circular RNAs (circRNA), a class of noncoding RNAs, have been found to be involved in various diseases. Here, the expression levels circRNA hsa_circ_0001445 73 pairs hepatocellular carcinoma (HCC) and adjacent nontumor tissues were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). Our data demonstrate that significantly decreased HCC (P < 0.001) markedly associated with number tumor foci = 0.014). Furthermore, vitro approaches showed overexpression promoted...
LncRNAs play critical roles in gastric cancer (GC). In this study, the expression of fourteen related lncRNAs were investigated paired tissues 66 patients with GC, real-time RT-PCR revealed that ZFAS1 was significantly upregulated. We then examined plasmas derived from 77 GC before- and post-operations 60 healthy individuals, found circulating also upregulated operation can reduce its presence plasma. To investigate potential mechanisms, we compared multiple cell lines one normal line...
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, which remains a threat to female health at all ages. Hypotheses for EOC development include continuous presence of inflammation, in microbiota and inflammatory cytokines participate cancer-related signaling pathway activation. Hedgehog (Hh) prominent progression, interacts with inflammation response related gut (GM). However, precise roles GM during this process are unknown. Here, we showed that from patients differed...
EGFR-dependent cell migration plays an important role in lung cancer progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is significantly correlated with tumor metastasis and required for invasion signaling of EGFR gastric cells. However, how promotes unknown. This to elucidate mechanism by which mediates signaling. Lentiviral vector-loaded shRNA was used deplete endogenous lines. Effects knockdown on or independent were determined using wound-healing transwell...
Long noncoding RNA (LncRNA) homeotic genes (HOX) transcript antisense (HOTAIR) has been reported to play a vital role in various cancers. It found that HOTAIR was upregulated non–small cell lung cancer (NSCLC) and involved invasion metastasis. The aberrant expression of is expected serve as potential biomarker for patients with NSCLC. Our aim this study detect the plasma levels further evaluate its diagnostic value were measured 105 NSCLC 80 healthy controls by quantitative real-time...
Background: Circular RNAs (circRNAs) are a class of widely distributed non-coding RNAs, which drew little attention for decades. Recent studies show that circRNAs involved in cancer progression. Methods: The circSMAD2 expression HCC and adjacent non-tumor tissues was measured by quantitative real-time polymerase chain reaction, the biological function explored proliferation, apoptosis, migration, invasion, Western blot assays. Next, dual-luciferase reporter assay performed to identify target...
Abstract Alzheimer’s disease (AD) and Parkinson’s (PD) are neurodegenerative diseases (NDD) characterized by progressive degeneration of the central nervous system, few medications available to halt progression AD PD. In present study, an engineered strain MG136-pMG36e-GLP-1 was used evaluate its neuroprotective effect on PD mice, via probiotics effects Lactococcus lactis MG1363 constantly produced Glucagon-like peptide-1 (GLP-1) strain. Our results indicated that oral administration...
BACKGROUND:Circular RNAs (circRNA)are involved in the progression of cancers, and previous study showed that hsa_circ_0001649 expression is down-regulated hepatocellular carcinoma (HCC). OBJECTIVE:To explore whether a prognostic biomarker for HCC to investigate biolog ical functions HCC. METHODS: Hsa_circ_0001649 was measured 77 pairs adjacent no-tumor tissues by quantitative Real-Time polymerase chain reaction. Kaplan-Meier curve Cox regression were used analyze its significance patients....
Hepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity high. Tissue biopsy an invasive operation and may increase risk of needle-track metastases. Heat shock protein 90 (HSP90) potential biomarker for diagnosis prognosis. This study aims to determine whether levels plasma HSP90α in HCC patients can be used as cost-effective simple test initial disease.Plasma samples were collected from 659...
Population aging is a prominent global problem in today’s society. However, there are currently no good methods to treat or prevent aging, so anti-aging research has crucial implications. In this research, we screened bacteria from centenarians, and finally selected four probiotics (Lactobacillus fermentum SX-0718, L. casei SX-1107, Bifidobacterium longum SX-1326 , B. animalis SX-0582 ) form probiotic combination. By using the senescence accelerated mouse prone 8 (SAMP8) model, effects of...
Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon-like peptide-1 (GLP-1). However, the extremely short half-life of GLP-1 due degradation by ubiquitous proteolytic enzyme limits its clinical application. In this study, we engineered recombinant integrant probiotic strain
Abstract Hypertension is a significant risk factor of cardiovascular diseases (CVDs) with high prevalence worldwide, the current treatment has multiple adverse effects and requires continuous administration. The glucagon‐like peptide‐1 receptor (GLP‐1R) agonists have shown great potential in treating diabetes mellitus, neurodegenerative diseases, obesity hypertension. Butyric acid target Yet, application GLP‐1 analogue butyric reducing blood pressure reversing ventricular hypertrophy remains...