A5087224208- Heat shock proteins research
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Tea Polyphenols and Effects
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Tannin, Tannase and Anticancer Activities
- Inflammatory Biomarkers in Disease Prognosis
- Endoplasmic Reticulum Stress and Disease
- Congenital Heart Disease Studies
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Congenital heart defects research
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- Phytochemicals and Antioxidant Activities
- Monoclonal and Polyclonal Antibodies Research
- Nanocluster Synthesis and Applications
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
Guangxi Medical University
2013-2025
Tumor Hospital of Guangxi Medical University
2012-2024
Liuzhou Maternal and Child Health Hospital
2012
University of Copenhagen
2006-2010
Despite extensive progress in treatment for cancer recent decades, the early diagnosis gastric (GC) and colorectal (CRC) remains poor.In this study, we explore diagnostic value of joint detection thymidine kinase 1 (TK1), carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA 19-9) 72-4 72-4) GC CRC, to evaluated relationship between TK1 expression clinical pathological characteristics patients.Serum TK1, CA 19-9, CEA levels were measured 169 patients with GC, 344 CRC 75 healthy controls...
We aimed to develop and validate a comprehensive nomogram containing pre-treatment plasma HSP90AA1 predict the risk of breast cancer onset metastasis.We assessed expression HSP90s in patients using an online database. To verify results, 677 diagnosed with 146 benign disease between 2014 2019 were selected from our hospital divided into metastasis cohorts. focused on elucidate risks cohorts.Expression levels HSP90AA1, HSP90AA2, HSP90AB1, HSP90B1, TRAP1 linked progression. Survival analysis...
An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities effective separation of charges, which can catalyze hydrogen peroxide (H2O2) to toxic hydroxyl...
Abstract Ferroptosis is a newly identified type of regulated cell death characterized by iron‐dependent lipid peroxidation. Among the main ferroptosis‐suppressing systems, dihydroorotate dehydrogenase (DHODH)‐ ubiquinone axis closely related to mitochondria and energy metabolism, implying that protects cells from oxidative stress damage via maintenance redox homeostasis. However, ferroptosis initiation requires suitable environment breakthrough in homeostatic limitations systems. Hence,...
<h3>Background:</h3> Congenital heart disease (CHD) is the most common birth defect and affects nearly 1% of newborns. The aetiology CHD largely unknown only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms syndromic CHD, but very little known about impact DNA copy number changes non-syndromic CHD. <h3>Method:</h3> A sub-megabase resolution array...
Epigallocatechin-3-gallate (EGCG) has been shown to inhibit the growth and induce apoptosis of certain cancer cells. The aim this study was determine role EGCG in hepatocellular carcinoma (HCC) underlying mechanism(s) thereof. MTT assay used cell inhibition by EGCG. Apoptosis induced investigated both AO/EB staining flow cytometry. cycle distribution analyzed mRNA levels AKT pathway were quantitative PCR. expression its phosphorylation at Ser473 detected western blotting. IC50 48 h for...
Increasing evidence has demonstrated that circulating microRNAs (miRNAs) can be utilized as potential biomarkers for the diagnosis of cancer, well a prognostic tool management disease. Therefore, present study aimed to evaluate predictive ability miRNA (miR)‑155, miR‑96 and miR‑99a prognosis hepatocellular carcinoma (HCC). Tissues were collected from 30 patients with HCC their matched adjacent normal liver tissues, serum samples healthy controls. Reverse transcription‑quantitative PCR was...
Hepatocellular carcinoma (HCC) is a major health problem worldwide. However, the popular tumor marker, AFP, lacks sensitivity although its specificity high. Tissue biopsy an invasive operation and may increase risk of needle-track metastases. Heat shock protein 90 (HSP90) potential biomarker for diagnosis prognosis. This study aims to determine whether levels plasma HSP90α in HCC patients can be used as cost-effective simple test initial disease.Plasma samples were collected from 659...
Background: Emerging evidence suggests that inflammatory response biomarkers are predictive factors can improve the accuracy of colorectal cancer (CRC) prognoses. We aimed to evaluate prognostic significance C-reactive protein (CRP), Glasgow Prognostic Score (GPS), and CRP-to-albumin ratio (CAR) in CRC. Methods: Overall, 307 stage I-III CRC patients 72 liver metastases (CRLM) were enrolled between October 2013 September 2019. investigated correlation pretreatment CRP, GPS, CAR...
This study aims to clarify the prognostic significance of metastasis-related indicators in peripheral blood stage I-III breast cancer (BC).The clinicopathological data 938 patients and 509 benign disease were retrospectively analyzed, fasting samples collected before treatment. Univariate multivariate regression analyses used evaluate factors related metastasis risk prognosis. The Kaplan-Meier method was generate survival curves, log-rank test measure differences between groups.Use cut-off...
(-)-Epigallocatechingallate (EGCG) as a representative polyphenol has attracted increasing attention due to its diversified effects, especially potential an agent for the prevention or treatment of certain cancers. However, molecular mechanisms EGCG-induced apoptosis in B lymphoma cells are unclear. The aim this study was investigate effect EGCG on proliferation and cell lines Jeko-1 Raji, determine underlying mechanisms. Cell cytotoxicity were determined by counting kit (CCK-8) assay;...
The tumor microenvironment and multidrug resistance of cells seriously impair the activity nanozymes.
We investigated the levels of target lymphocyte subsets in peripheral blood samples from patients with hepatocellular carcinoma (HCC). A total 715 high-risk primary HCC were recruited Guangxi, China as case group. The control group included 100 who received health examinations at same hospital during period. Fasting elbow venous (10 mL) was collected each participant, and flow cytometry used to detect NK cells CD3+, CD4+ CD19+ T samples. All prmary treated by surgical resection, followed up...
Background: Chemodynamic therapy (CDT) is a new treatment approach that triggered by endogenous stimuli in specific intracellular conditions for generating hydroxyl radicals. However, the efficiency of CDT severely limited Fenton reaction agents and harsh conditions. Methods: Bimetallic PtMn nanocubes were rationally designed simply synthesized through one-step high-temperature pyrolysis process controlling both nucleation subsequent crystal growth stage. The polyethylene glycol was modified...
An association between epidermal growth factor receptor (EGFR) and clinical characteristics of non-small cell lung cancer (NSCLC) was reported ten years ago. In addition, a different type relationship seen in ethic races. However, the these factors is not well understood Guangxi province. Up to now, there are only very limited data on TTF1/EGFR protein positivity EGFR mutation status NSCLC. This study aims investigate role gene with TTF-1/EGFR patients NSCLC Guangxi, China. 1506 samples from...
Object: This study aims to clarify the expression of plasma miRNA in CRC patients, and potential use these miRNAs diagnosis prognosis, establish a prognostic model initially explore its clinical value. Methods: We detected 6 normal colon epithelial cell lines colorectal cancer by qRT-PCR they were validated tissues three subtypes: 20 healthy subjects, 41 pCRC 49 mCRC patients. COX regression ROC analyses evaluate diagnostic efficacy candidate miRNAs. Subsequently, we established nomogram...
The present study aimed to investigate the chemopreventive effect of Camellia nitidissima flowers water extract (CNFE) on Eca109 human esophageal squamous cell carcinoma (ESCC) line. antiproliferative cells was determined using trypan blue exclusion assay. effects CNFE apoptosis and cycle arrest were investigated by flow cytometry. inhibited growth in both a dose‑ time‑dependent manner cells. also caused these Treatment with resulted dose‑dependent G0/G1 phase cycle. data demonstrated that...
Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic such as phototherapy, chemodynamic therapy, gasodynamic therapy been innovatively developed. High concentrations of hydrogen sulfide (H2S) gas exhibit cancer-suppressive Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H2S signaling molecule release...
Congenital heart disease (CHD) affects nearly 1% of the population, but only few genes involved in human CHD are presently known. Germ-line mutations zinc finger transcription factor GATA4 have been associated with familial cases atrial and ventricular septal defects pulmonary stenosis. We screened 99 unrelated Danish patients different phenotypes to evaluate prevalence CHD. No pathogenic were found among patients, suggesting that relatively rare patients. Thus, diagnostic importance may be...