A5100713962- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Extracellular vesicles in disease
- Sulfur Compounds in Biology
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Soil and Unsaturated Flow
- Luminescence and Fluorescent Materials
- Anaerobic Digestion and Biogas Production
- Photoacoustic and Ultrasonic Imaging
- Wastewater Treatment and Nitrogen Removal
Guangxi University of Science and Technology
2025
Guangxi Medical University
2022-2024
Abstract Single‐atom nanozymes (SAzymes) can effectively mimic the metal active centers of natural enzymes at atomic level owing to their atomically dispersed sites, thereby maximizing atom utilization efficiency and density sites. Hence, SAzymes be considered most promising candidates replace enzymes. Herein, a PEGylated mesoporous Mn‐based single‐atom nanozyme (PmMn/SAE) employing coordination‐assisted polymerization pyrolysis strategy that uses polydopamine for photothermal‐augmented...
Biodegradable silicate nanoconstructs have aroused tremendous interest in cancer therapeutics due to their variable framework composition and versatile functions. Nevertheless, low intratumoral retention still limits practical application. In this study, oxygen vacancy (OV)-enriched bimetallic nanozymes with Fe–Ca dual active sites via modification of oxidized sodium alginate gallic acid (GA) loading (OFeCaSA-V@GA) were developed for targeted aggregation-potentiated therapy. The band gap...
Introduction: Reactive oxygen species (ROS)-mediated therapies have typically been considered as noninvasive tumor treatments owing to their high selectivity and efficiency. However, the harsh microenvironment severely impairs Methods: Herein, biodegradable Cu-doped zeolitic imidazolate framework-8 (ZIF-8) was synthesized for loading photosensitizer Chlorin e6 (Ce6) CaO2 nanoparticles, followed by surface decoration hyaluronic acid (HA), obtaining HA/CaO2-Ce6@Cu-ZIF nano platform. Results...
Abstract Calcium overload can lead to tumor cell death. However, because of the powerful calcium channel excretory system within cells, simplistic overloads do not allow for an effective antitumor therapy. Hence, nanoparticles are created with polyethylene glycol (PEG) donor‐modified phosphate (CaP)‐coated, manganese‐doped hollow mesopores Prussian blue (MMPB) encapsulating glucose oxidase (GOx), called GOx@MMPB@CaP‐PEG (GMCP). GMCP a three‐mode enhancement intratumor reactive oxygen species...
Dual atomic nanozymes (DAzymes) are promising for applications in the field of tumor catalytic therapy. Here, integrating with ultrasmall Fe5C2 nanoclusters, asymmetric coordination featuring Janus Zn-Fe dual-atom sites an O2N2-Fe-Zn-N4 moiety embedded a carbon vacancy-engineered hollow nanobox (Janus ZnFe DAs-Fe5C2) was elaborately developed. Theoretical calculation revealed that synergistic effects Zn centers acting as both adsorption and active sites, oxygen-heteroatom doping, vacancy,...
Background: Chemodynamic therapy (CDT) is a new treatment approach that triggered by endogenous stimuli in specific intracellular conditions for generating hydroxyl radicals. However, the efficiency of CDT severely limited Fenton reaction agents and harsh conditions. Methods: Bimetallic PtMn nanocubes were rationally designed simply synthesized through one-step high-temperature pyrolysis process controlling both nucleation subsequent crystal growth stage. The polyethylene glycol was modified...
Traditional treatment methods for tumors are inefficient and have severe side effects. At present, new therapeutic such as phototherapy, chemodynamic therapy, gasodynamic therapy been innovatively developed. High concentrations of hydrogen sulfide (H2S) gas exhibit cancer-suppressive Herein, a Prussian blue-loaded tetra-sulfide modified dendritic mesoporous organosilica (PB@DMOS) was rationally constructed with glutathione (GSH)-triggered/photothermal-enhanced H2S signaling molecule release...
Hyperthermia therapy is a hotspot because of its minimally invasive treatment process and strong targeting effect. Herein, synergistic magnetic photothermal therapeutic nanoplatform rationally constructed. The well-dispersive mSiO 2 -SmCo x nanoparticles (NPs) were synthesized through one-step procedure with the regulated theoretical molar ratio Sm/Co among 1:1, 1:2, 1:4 for controlling dispersion magnetism properties SmCo NPs in situ growth pore structure mesoporous SiO (mSiO ), where...
The clinical application of reactive oxygen species (ROS)-mediated tumor treatment has been critically limited by inefficient ROS generation. Herein, we rationally synthesized and constructed the three-dimensional PdMo nanoflowers through a one-pot solvothermal reduction method for elaborately regulated peroxidase-like enzymatic activity glutathione activity, to promote oxidation evolvement antioxidation depletion achieving intensive ROS-mediated therapy. superstructure composed...